Criteria Fulfill
Item
patients will be deemed eligible for inclusion if all the following criteria are met.
boolean
C0243161 (UMLS CUI [1,1])
C1550543 (UMLS CUI [1,2])
Nasopharyngeal cancer recurrent Local TNM clinical staging | Nasopharyngeal carcinoma Persistent Local TNM clinical staging | Nasopharyngeal cancer recurrent Locoregional TNM clinical staging | Nasopharyngeal carcinoma Persistent Locoregional TNM clinical staging | Disease length Post Therapeutic radiology procedure
Item
histologically confirmed local or locoregional recurrent or persistent npc, [t1-2a, n1-2; m0] at least 3 months following a full course of irradiation
boolean
C0278952 (UMLS CUI [1,1])
C0205276 (UMLS CUI [1,2])
C3258246 (UMLS CUI [1,3])
C2931822 (UMLS CUI [2,1])
C0205322 (UMLS CUI [2,2])
C0205276 (UMLS CUI [2,3])
C3258246 (UMLS CUI [2,4])
C0278952 (UMLS CUI [3,1])
C1947913 (UMLS CUI [3,2])
C3258246 (UMLS CUI [3,3])
C2931822 (UMLS CUI [4,1])
C0205322 (UMLS CUI [4,2])
C1947913 (UMLS CUI [4,3])
C3258246 (UMLS CUI [4,4])
C0872146 (UMLS CUI [5,1])
C0687676 (UMLS CUI [5,2])
C1522449 (UMLS CUI [5,3])
Tumor Discrete Depth | Tumor Visible Endoscopy | Tumor Amenable Illumination
Item
discrete tumour, less or equal to 15 mm in depth, which is endoscopically visible and accessible for unrestricted surface illumination using a nasopharyngeal applicator, with no bony invasion
boolean
C0027651 (UMLS CUI [1,1])
C0443299 (UMLS CUI [1,2])
C0205125 (UMLS CUI [1,3])
C0027651 (UMLS CUI [2,1])
C0205379 (UMLS CUI [2,2])
C0014245 (UMLS CUI [2,3])
C0027651 (UMLS CUI [3,1])
C3900053 (UMLS CUI [3,2])
C1964256 (UMLS CUI [3,3])
Age | Legal capacity
Item
patient is 18 - 69 years of age, and legally competent
boolean
C0001779 (UMLS CUI [1])
C0683673 (UMLS CUI [2])
ECOG performance status
Item
patient has a ecog performance status ≤2
boolean
C1520224 (UMLS CUI [1])
Gender | Pregnancy Absent | Breast Feeding Absent
Item
patient is a man or a non-pregnant, non-lactating woman
boolean
C0079399 (UMLS CUI [1])
C0032961 (UMLS CUI [2,1])
C0332197 (UMLS CUI [2,2])
C0006147 (UMLS CUI [3,1])
C0332197 (UMLS CUI [3,2])
Informed Consent | Informed Consent Patient Representative
Item
patient, or his legally appointed representative, is able and willing to provide informed consent to participate in the study
boolean
C0021430 (UMLS CUI [1])
C0021430 (UMLS CUI [2,1])
C0030701 (UMLS CUI [2,2])
Criteria Fulfill
Item
patients will not be deemed eligible for inclusion if any of the following criteria apply.
boolean
C0243161 (UMLS CUI [1,1])
C1550543 (UMLS CUI [1,2])
Elective Surgical Procedures Planned | Foscan
Item
elective surgery is planned for within 30 days of administration of foscan®
boolean
C0206058 (UMLS CUI [1,1])
C1301732 (UMLS CUI [1,2])
C0701505 (UMLS CUI [2])
Disease caused by Light | Disease Exacerbation Due to Light | Lupus Erythematosus, Systemic | Psoriasis | Porphyria | Actinic reticuloid | Xeroderma Pigmentosum
Item
patient has any disease, which is caused or exacerbated by light, including systemic lupus erythematosus, psoriasis, porphyria, actinic reticuloid or xeroderma pigmentosum
boolean
C0012634 (UMLS CUI [1,1])
C0015127 (UMLS CUI [1,2])
C0023693 (UMLS CUI [1,3])
C0235874 (UMLS CUI [2,1])
C0678226 (UMLS CUI [2,2])
C0023693 (UMLS CUI [2,3])
C0024141 (UMLS CUI [3])
C0033860 (UMLS CUI [4])
C3463940 (UMLS CUI [5])
C0282309 (UMLS CUI [6])
C0043346 (UMLS CUI [7])
Phototherapy | Pharmaceutical Preparations Relationship Photosensitivity of skin | PUVA | Accutane
Item
patient has been treated within the prior 30 days with a light-activated therapy or other medication that may render the patient photosensitive (e.g., psoralen ultraviolet a-range [puva], accutane)
boolean
C0031765 (UMLS CUI [1])
C0013227 (UMLS CUI [2,1])
C0439849 (UMLS CUI [2,2])
C0349506 (UMLS CUI [2,3])
C0853073 (UMLS CUI [3])
C0699581 (UMLS CUI [4])
Photochemotherapy Treatment site
Item
patient has received prior photodynamic therapy to the proposed treatment site within the prior 3 months
boolean
C0031740 (UMLS CUI [1,1])
C0337950 (UMLS CUI [1,2])
Comorbidity ophthalmic Requirement Slit lamp biomicroscopy
Item
patient has co-existing ophthalmic disease, which is likely to require slit lamp examination within 30 days following foscan® administration
boolean
C0009488 (UMLS CUI [1,1])
C0015392 (UMLS CUI [1,2])
C1514873 (UMLS CUI [1,3])
C0419360 (UMLS CUI [1,4])
Hypersensitivity Temoporfin | Hypersensitivity Temoporfin Excipient | Hypersensitivity Porphyrins
Item
patient has a known hypersensitivity to temoporfin, or any of the excipients, or to porphyrins
boolean
C0020517 (UMLS CUI [1,1])
C0379149 (UMLS CUI [1,2])
C0020517 (UMLS CUI [2,1])
C0379149 (UMLS CUI [2,2])
C0015237 (UMLS CUI [2,3])
C0020517 (UMLS CUI [3,1])
C0032712 (UMLS CUI [3,2])
Tumor Impairing Blood Vessel Major | Tumor Impairing Illumination Site
Item
patient has a tumour known to be eroding into a major blood vessel in, or adjacent to, the proposed illumination site
boolean
C0027651 (UMLS CUI [1,1])
C0221099 (UMLS CUI [1,2])
C0005847 (UMLS CUI [1,3])
C0205164 (UMLS CUI [1,4])
C0027651 (UMLS CUI [2,1])
C0221099 (UMLS CUI [2,2])
C1964256 (UMLS CUI [2,3])
C1515974 (UMLS CUI [2,4])
Childbearing Potential Contraceptive methods Unwilling | Patients Contraceptive methods | Contraceptives, Oral, Hormonal | Intrauterine Devices | Exception Postmenopausal state | Exception Hysterectomy
Item
patient is of childbearing potential and will not use adequate contraceptive protection. patient should practice strict birth control (oestrogen-containing oral contraceptives or an intrauterine device) throughout the study. only post-menopausal women (at least 2 years since the onset of the menopause) and women who have had a hysterectomy are exempt from the requirement to use birth control.
boolean
C3831118 (UMLS CUI [1,1])
C0700589 (UMLS CUI [1,2])
C0558080 (UMLS CUI [1,3])
C0030705 (UMLS CUI [2,1])
C0700589 (UMLS CUI [2,2])
C0009907 (UMLS CUI [3])
C0021900 (UMLS CUI [4])
C1705847 (UMLS CUI [5,1])
C0232970 (UMLS CUI [5,2])
C1705847 (UMLS CUI [6,1])
C0020699 (UMLS CUI [6,2])
Investigational New Drugs
Item
patient has received treatment with an experimental drug within the prior 30 days
boolean
C0013230 (UMLS CUI [1])
Radiation therapy to the head and neck
Item
patient has received radiotherapy to the head and neck region within the prior 3 months
boolean
C4540910 (UMLS CUI [1])
Protocol Compliance Unwilling | Protocol Compliance Unable | Exposure to light Instructions Adherence Unwilling | Exposure to light Instructions Adherence Unable
Item
patient is not willing or able to complete the visit requirements of this protocol or adhere to the instructions regarding light exposure
boolean
C0525058 (UMLS CUI [1,1])
C0558080 (UMLS CUI [1,2])
C0525058 (UMLS CUI [2,1])
C1299582 (UMLS CUI [2,2])
C1689916 (UMLS CUI [3,1])
C1442085 (UMLS CUI [3,2])
C1510802 (UMLS CUI [3,3])
C0558080 (UMLS CUI [3,4])
C1689916 (UMLS CUI [4,1])
C1442085 (UMLS CUI [4,2])
C1510802 (UMLS CUI [4,3])
C1299582 (UMLS CUI [4,4])