Nasopharyngeal carcinoma Grade WHO tumor classification | Epstein-Barr Virus Infection | Epstein-Barr Virus Early RNA Present Tumor In Situ Hybridization | Epstein-Barr Virus Early RNA Positive Staining | Disease Associated with Epstein-Barr Virus | Epstein-Barr virus DNA In Situ Hybridization
Item
histologically or cytologically proven npc of an who grade, associated with ebv infection documented by the presence of eber expression by in situ hybridization in the tumor. positive eber staining from another institution must be confirmed by pathology review at brigham and women's hospital. other confirmation of ebv-associated disease is acceptable, such as ebv dna in situ hybridization, if eber analysis is not adequate
boolean
C2931822 (UMLS CUI [1,1])
C0441800 (UMLS CUI [1,2])
C1301142 (UMLS CUI [1,3])
C0149678 (UMLS CUI [2])
C3830308 (UMLS CUI [3,1])
C0150312 (UMLS CUI [3,2])
C0027651 (UMLS CUI [3,3])
C0162788 (UMLS CUI [3,4])
C4289579 (UMLS CUI [4,1])
C0487602 (UMLS CUI [4,2])
C0012634 (UMLS CUI [5,1])
C0332281 (UMLS CUI [5,2])
C0014644 (UMLS CUI [5,3])
C0369169 (UMLS CUI [6,1])
C0162788 (UMLS CUI [6,2])
Nasopharyngeal carcinoma incurable
Item
incurable npc
boolean
C2931822 (UMLS CUI [1,1])
C0175969 (UMLS CUI [1,2])
Toxicity Due to Prior Therapy Nasopharyngeal carcinoma | Patient recovered | Toxicity CTCAE Grades
Item
recovery from toxicity from any prior npc therapy to grade 1 or better
boolean
C0600688 (UMLS CUI [1,1])
C0678226 (UMLS CUI [1,2])
C1514463 (UMLS CUI [1,3])
C2931822 (UMLS CUI [1,4])
C1115804 (UMLS CUI [2])
C0600688 (UMLS CUI [3,1])
C1516728 (UMLS CUI [3,2])
Age
Item
18 years of age or older
boolean
C0001779 (UMLS CUI [1])
Evaluable Disease | Measurable Disease
Item
evaluable or measurable disease, according to modified recist
boolean
C1516986 (UMLS CUI [1])
C1513041 (UMLS CUI [2])
ECOG performance status
Item
ecog performance status of 0 or 1
boolean
C1520224 (UMLS CUI [1])
Bone Marrow function | Liver function | Renal function
Item
adequate bone marrow, liver and renal function as outlined in protocol
boolean
C0005953 (UMLS CUI [1,1])
C0031843 (UMLS CUI [1,2])
C0232741 (UMLS CUI [2])
C0232804 (UMLS CUI [3])
Therapeutic radiology procedure Nasopharyngeal carcinoma Primary | Therapeutic radiology procedure Reason Any
Item
radiotherapy for primary npc within 8 weeks of enrollment, or radiotherapy for any other reason within 6 weeks
boolean
C1522449 (UMLS CUI [1,1])
C2931822 (UMLS CUI [1,2])
C0205225 (UMLS CUI [1,3])
C1522449 (UMLS CUI [2,1])
C0392360 (UMLS CUI [2,2])
C1552551 (UMLS CUI [2,3])
Chemotherapy Nasopharyngeal carcinoma
Item
chemotherapy for npc within 2 weeks of enrollment
boolean
C0392920 (UMLS CUI [1,1])
C2931822 (UMLS CUI [1,2])
Cancer Other | Exception Carcinoma in situ of uterine cervix | Exception Carcinoma in situ of bladder | Exception Skin carcinoma
Item
other cancer in the past 5 years, except for carcinoma in situ of the cervix or bladder, or non-melanomatous skin cancer
boolean
C1707251 (UMLS CUI [1])
C1705847 (UMLS CUI [2,1])
C0851140 (UMLS CUI [2,2])
C1705847 (UMLS CUI [3,1])
C0154091 (UMLS CUI [3,2])
C1705847 (UMLS CUI [4,1])
C0699893 (UMLS CUI [4,2])
CNS metastases Uncontrolled
Item
uncontrolled central nervous system metastases
boolean
C0686377 (UMLS CUI [1,1])
C0205318 (UMLS CUI [1,2])
Hepatitis | HIV Infection | Condition Requirement Therapeutic immunosuppression | CORTICOSTEROIDS FOR SYSTEMIC USE High dose
Item
active hepatitis, known hiv, or other condition that requires immunosuppressive therapy, including current use of high dose systemic corticosteroids
boolean
C0019158 (UMLS CUI [1])
C0019693 (UMLS CUI [2])
C0348080 (UMLS CUI [3,1])
C1514873 (UMLS CUI [3,2])
C0021079 (UMLS CUI [3,3])
C3653708 (UMLS CUI [4,1])
C0444956 (UMLS CUI [4,2])
Autoimmune Disease Requirement Therapeutic immunosuppression | Lupus Erythematosus, Systemic | Rheumatoid Arthritis
Item
autoimmune disease, such as systemic lupus erythematosis or rheumatoid arthritis, that is active and requires current immunosuppressive therapy
boolean
C0004364 (UMLS CUI [1,1])
C1514873 (UMLS CUI [1,2])
C0021079 (UMLS CUI [1,3])
C0024141 (UMLS CUI [2])
C0003873 (UMLS CUI [3])
Communicable Disease Serious Uncontrolled
Item
active uncontrolled serious infection
boolean
C0009450 (UMLS CUI [1,1])
C0205404 (UMLS CUI [1,2])
C0205318 (UMLS CUI [1,3])
Childbearing Potential Pregnancy test positive | Breast Feeding
Item
women of child-bearing potential who have a positive pregnancy test or are breast-feeding
boolean
C3831118 (UMLS CUI [1,1])
C0240802 (UMLS CUI [1,2])
C0006147 (UMLS CUI [2])