Informed Consent
Item
signed, written informed consent
boolean
C0021430 (UMLS CUI [1])
Age | Gender Pregnancy Absent
Item
males or non-pregnant females, 18-60 years of age (inclusive)
boolean
C0001779 (UMLS CUI [1])
C0079399 (UMLS CUI [2,1])
C0032961 (UMLS CUI [2,2])
C0332197 (UMLS CUI [2,3])
Multiple Sclerosis, Primary Progressive
Item
clinically definite ppms as per the diagnostic criteria of thompson et al (2000)
boolean
C0751964 (UMLS CUI [1])
EDSS | Assistance Constant Required
Item
expanded disability status score 5.0-8.0 (constant assistance required)
boolean
C0451246 (UMLS CUI [1])
C1269765 (UMLS CUI [2,1])
C1948059 (UMLS CUI [2,2])
C1514873 (UMLS CUI [2,3])
Body Weight
Item
body weight <90kg (due to support limitations of treadmill)
boolean
C0005910 (UMLS CUI [1])
Participation Exercise Program Approved
Item
approval from physician to participate in the exercise program
boolean
C0679823 (UMLS CUI [1,1])
C0015259 (UMLS CUI [1,2])
C3484370 (UMLS CUI [1,3])
C0205540 (UMLS CUI [1,4])
Locomotion Upright Ability | Body Weight Supported Treadmill
Item
ability to tolerate upright locomotion of the body weight supported treadmill
boolean
C0023946 (UMLS CUI [1,1])
C0522015 (UMLS CUI [1,2])
C0085732 (UMLS CUI [1,3])
C0005910 (UMLS CUI [2,1])
C1521721 (UMLS CUI [2,2])
C0184069 (UMLS CUI [2,3])
Visit Study Site Different
Item
ability to visit the different sites required for the study
boolean
C1512346 (UMLS CUI [1,1])
C2347790 (UMLS CUI [1,2])
C1705242 (UMLS CUI [1,3])
Training Session Quantity Weekly
Item
ability to commit to 3 weekly training sessions for the duration of 24 weeks
boolean
C2673163 (UMLS CUI [1,1])
C1883016 (UMLS CUI [1,2])
C1265611 (UMLS CUI [1,3])
C0332174 (UMLS CUI [1,4])
Disability caused by Trauma | Disability caused by Illness | Interference Evaluation Multiple Sclerosis Disability
Item
any disability acquired from trauma or another illness that could interfere with evaluation of disability due to ms
boolean
C0231170 (UMLS CUI [1,1])
C0015127 (UMLS CUI [1,2])
C3714660 (UMLS CUI [1,3])
C0231170 (UMLS CUI [2,1])
C0015127 (UMLS CUI [2,2])
C0221423 (UMLS CUI [2,3])
C0521102 (UMLS CUI [3,1])
C1261322 (UMLS CUI [3,2])
C0026769 (UMLS CUI [3,3])
C0231170 (UMLS CUI [3,4])
Other medical condition Serious | Impairment Able to walk Treadmill | Impairment Participation Aerobic Exercise | Heart Disease | Angina, Unstable | Cardiac Arrhythmia Uncontrolled | Chronic Obstructive Airway Disease | Nontraumatic fracture | Osteoporosis | Skin Ulcer Severe
Item
any other serious medical condition that might impair the subject's ability to walk on a treadmill and/or participate in aerobic exercise (including but not limited to: documented heart disease or unstable angina, uncontrolled cardiac dysrhythmia, chronic obstructive lung disease, recent non-traumatic fracture, osteoporosis and severe skin ulcerations)
boolean
C3843040 (UMLS CUI [1,1])
C0205404 (UMLS CUI [1,2])
C0221099 (UMLS CUI [2,1])
C2712089 (UMLS CUI [2,2])
C0184069 (UMLS CUI [2,3])
C0221099 (UMLS CUI [3,1])
C0679823 (UMLS CUI [3,2])
C0001701 (UMLS CUI [3,3])
C0018799 (UMLS CUI [4])
C0002965 (UMLS CUI [5])
C0003811 (UMLS CUI [6,1])
C0205318 (UMLS CUI [6,2])
C0024117 (UMLS CUI [7])
C4295197 (UMLS CUI [8])
C0029456 (UMLS CUI [9])
C0037299 (UMLS CUI [10,1])
C0205082 (UMLS CUI [10,2])
Gender Contraceptive methods Unwilling
Item
female patients who do not agree to use effective contraceptive method(s) during the study
boolean
C0079399 (UMLS CUI [1,1])
C0700589 (UMLS CUI [1,2])
C0558080 (UMLS CUI [1,3])
Biological Response Modifiers | Interferon-beta | glatiramer acetate | Intravenous steroids | Mitoxantrone | Azathioprine | Cyclophosphamide
Item
current use or use within the last 2 months of any on- or off-label disease-modifying therapy including ifn-β, glatiramer acetate, iv steroids, mitoxantrone, azathioprine, and cyclophosphamide
boolean
C0005525 (UMLS CUI [1])
C0015980 (UMLS CUI [2])
C0289884 (UMLS CUI [3])
C0563322 (UMLS CUI [4])
C0026259 (UMLS CUI [5])
C0004482 (UMLS CUI [6])
C0010583 (UMLS CUI [7])
Experience Treadmill Training Supported
Item
previous experience with supported treadmill training
boolean
C0237607 (UMLS CUI [1,1])
C0184069 (UMLS CUI [1,2])
C2673163 (UMLS CUI [1,3])
C1521721 (UMLS CUI [1,4])
Kidney Disease | Peripheral Vascular Disease | Circulation Poor
Item
kidney disease, peripheral vascular disease or poor circulation
boolean
C0022658 (UMLS CUI [1])
C0085096 (UMLS CUI [2])
C0005775 (UMLS CUI [3,1])
C0542537 (UMLS CUI [3,2])
MRI Receive Unable | MRI Gadolinium Receive Unable
Item
inability to undergo mri or mri with gadolinium administration
boolean
C0024485 (UMLS CUI [1,1])
C1514756 (UMLS CUI [1,2])
C1299582 (UMLS CUI [1,3])
C0024485 (UMLS CUI [2,1])
C0016911 (UMLS CUI [2,2])
C1514756 (UMLS CUI [2,3])
C1299582 (UMLS CUI [2,4])