Multiple Sclerosis | Internuclear Ophthalmoplegia | Optic Neuritis
Item
1. subject has clinically or laboratory supported multiple sclerosis with evidence of ino by quantitative neurophysiologic criteria or has a history of on.
boolean
C0026769 (UMLS CUI [1])
C0152134 (UMLS CUI [2])
C0029134 (UMLS CUI [3])
Age
Item
2. subject is between the ages of 18-65.
boolean
C0001779 (UMLS CUI [1])
Informed Consent
Item
3. subject is able to understand the demands of the protocol, has had any questions answered and has voluntarily signed the informed consent prior to any study procedures.
boolean
C0021430 (UMLS CUI [1])
Peak Saccadic Acceleration Ratio
Item
4. subject has a peak saccadic acceleration ratio (abducting eye/adducting eye) of greater than 2s.d. above the mean derived form a normal control group.
boolean
C0444505 (UMLS CUI [1,1])
C0036019 (UMLS CUI [1,2])
C0000894 (UMLS CUI [1,3])
C0456603 (UMLS CUI [1,4])
General health good Medical History | General health good Physical Examination | General health good Vital signs | General health good Electrocardiography
Item
5. subject is otherwise in good health, based on complete medical history and physical examination, including vital signs and ecg.
boolean
C1277245 (UMLS CUI [1,1])
C0262926 (UMLS CUI [1,2])
C1277245 (UMLS CUI [2,1])
C0031809 (UMLS CUI [2,2])
C1277245 (UMLS CUI [3,1])
C0518766 (UMLS CUI [3,2])
C1277245 (UMLS CUI [4,1])
C1623258 (UMLS CUI [4,2])
Pregnancy Urine pregnancy test | Breast Feeding | Childbearing Potential Female Sterilization Absent | Childbearing Potential Contraceptive methods Absent | Contraceptives, Oral | Injectable contraception | Contraceptive implant | Contraception, Barrier
Item
1. subject is a pregnant female (as determined by a urine pregnancy test), a lactating female, or a female of child-bearing potential, not sterilized and not using one of the following methods of birth control: oral or injectable contraceptive agent, implantable contraceptive device, or barrier method.
boolean
C0032961 (UMLS CUI [1,1])
C0430056 (UMLS CUI [1,2])
C0006147 (UMLS CUI [2])
C3831118 (UMLS CUI [3,1])
C0015787 (UMLS CUI [3,2])
C0332197 (UMLS CUI [3,3])
C3831118 (UMLS CUI [4,1])
C0700589 (UMLS CUI [4,2])
C0332197 (UMLS CUI [4,3])
C0009905 (UMLS CUI [5])
C1262153 (UMLS CUI [6])
C1657106 (UMLS CUI [7])
C0004764 (UMLS CUI [8])
Hypertensive disease | Diabetes Mellitus
Item
2. subject has a history of hypertension or diabetes.
boolean
C0020538 (UMLS CUI [1])
C0011849 (UMLS CUI [2])
Hypersensitivity ACTH
Item
3. subject has known allergy to acth.
boolean
C0020517 (UMLS CUI [1,1])
C0001655 (UMLS CUI [1,2])
Medical condition Interferes with Interpretation Research results | Mental disorder Interferes with Interpretation Research results | Medical condition Interferes with Completion of clinical trial | Mental disorder Interferes with Completion of clinical trial
Item
4. the subject has any medical condition, including psychiatric disease that might interfere with the interpretation of the results or with the conduct of the study.
boolean
C3843040 (UMLS CUI [1,1])
C0521102 (UMLS CUI [1,2])
C0459471 (UMLS CUI [1,3])
C0683954 (UMLS CUI [1,4])
C0004936 (UMLS CUI [2,1])
C0521102 (UMLS CUI [2,2])
C0459471 (UMLS CUI [2,3])
C0683954 (UMLS CUI [2,4])
C3843040 (UMLS CUI [3,1])
C0521102 (UMLS CUI [3,2])
C2732579 (UMLS CUI [3,3])
C0004936 (UMLS CUI [4,1])
C0521102 (UMLS CUI [4,2])
C2732579 (UMLS CUI [4,3])
Substance Use Disorders
Item
5. subject has a history of drug or ethanol abuse within the past year.
boolean
C0038586 (UMLS CUI [1])
Myocardial Ischemia
Item
6. subject has a history of ischemic heart disease.
boolean
C0151744 (UMLS CUI [1])
Investigational New Drugs
Item
7. subject has received an investigational drug within 30 days of screening.
boolean
C0013230 (UMLS CUI [1])
Study Subject Completion of clinical trial Unlikely
Item
8. in opinion of investigator, subject is unlikely to complete study for any reason.
boolean
C0681850 (UMLS CUI [1,1])
C2732579 (UMLS CUI [1,2])
C0750558 (UMLS CUI [1,3])
Laboratory test result abnormal | Electrocardiogram abnormal
Item
9. the subject has abnormal clinical laboratory values or an abnormal ecg, without approval of the study monitor.
boolean
C0438215 (UMLS CUI [1])
C0522055 (UMLS CUI [2])