Patients At risk Multiple Sclerosis | Twin sibling female Discordant Clinically isolated syndrome | Twin sibling female Discordant Multiple Sclerosis
Item
'at risk' individuals for ms - female co-twins discordant for cis/ms.
boolean
C0030705 (UMLS CUI [1,1])
C1444641 (UMLS CUI [1,2])
C0026769 (UMLS CUI [1,3])
C0041427 (UMLS CUI [2,1])
C0043210 (UMLS CUI [2,2])
C3639994 (UMLS CUI [2,3])
C2921627 (UMLS CUI [2,4])
C0041427 (UMLS CUI [3,1])
C0043210 (UMLS CUI [3,2])
C3639994 (UMLS CUI [3,3])
C0026769 (UMLS CUI [3,4])
Patients At risk Multiple Sclerosis | Multiple Sclerosis Absent | Clinically isolated syndrome Absent
Item
'at risk' individuals for ms who at the time of randomization have not converted to ms or cis.
boolean
C0030705 (UMLS CUI [1,1])
C1444641 (UMLS CUI [1,2])
C0026769 (UMLS CUI [1,3])
C0026769 (UMLS CUI [2,1])
C0332197 (UMLS CUI [2,2])
C2921627 (UMLS CUI [3,1])
C0332197 (UMLS CUI [3,2])
Patients At risk Therapy naive Immunomodulators | Patients At risk Therapy naive Immunosuppressive Agents
Item
'at risk' individuals will be treatment-naïve for immunomodulatory/suppressive medications.
boolean
C0030705 (UMLS CUI [1,1])
C1444641 (UMLS CUI [1,2])
C0919936 (UMLS CUI [1,3])
C1527392 (UMLS CUI [1,4])
C0030705 (UMLS CUI [2,1])
C1444641 (UMLS CUI [2,2])
C0919936 (UMLS CUI [2,3])
C0021081 (UMLS CUI [2,4])
Age
Item
< 46 years old.
boolean
C0001779 (UMLS CUI [1])
Multiple Sclerosis | Clinically isolated syndrome
Item
individuals diagnosed with ms or cis.
boolean
C0026769 (UMLS CUI [1])
C2921627 (UMLS CUI [2])
First Degree Relative Multiple Sclerosis Index case | Second Degree Relative Multiple Sclerosis Index case | Third Degree Relative Multiple Sclerosis Index case
Item
other 'at risk' individuals who do not conform to the specific 'at risk' groups outlined above e.g., 1st degree, 2nd degree and 3rd degree relative of ms index cases.
boolean
C1517194 (UMLS CUI [1,1])
C0026769 (UMLS CUI [1,2])
C2597943 (UMLS CUI [1,3])
C1519210 (UMLS CUI [2,1])
C0026769 (UMLS CUI [2,2])
C2597943 (UMLS CUI [2,3])
C3639750 (UMLS CUI [3,1])
C0026769 (UMLS CUI [3,2])
C2597943 (UMLS CUI [3,3])
Age
Item
subjects over 45.
boolean
C0001779 (UMLS CUI [1])
Immunomodulators | Azathioprine U/day | Gold U/day | Sulfasalazine U/day | Minocycline U/day | Statins U/day | Methotrexate U/day | Prednisone U/day
Item
use of immunomodulatory medications such as azathioprine, gold, sulfasalazine, minocycline, statins, and mtx or prednisone > 7.5 mg/day within 30 days of randomization for any reason.
boolean
C1527392 (UMLS CUI [1])
C0004482 (UMLS CUI [2,1])
C0456683 (UMLS CUI [2,2])
C0018026 (UMLS CUI [3,1])
C0456683 (UMLS CUI [3,2])
C0036078 (UMLS CUI [4,1])
C0456683 (UMLS CUI [4,2])
C0026187 (UMLS CUI [5,1])
C0456683 (UMLS CUI [5,2])
C0360714 (UMLS CUI [6,1])
C0456683 (UMLS CUI [6,2])
C0025677 (UMLS CUI [7,1])
C0456683 (UMLS CUI [7,2])
C0032952 (UMLS CUI [8,1])
C0456683 (UMLS CUI [8,2])
Drug Use Disorders Interferes with Protocol Compliance | Drug Dependence Interferes with Protocol Compliance | Mental disorders Unstable | Mental disorders Study Subject Participation Status Excluded
Item
active drug use or dependence that, in the opinion of the site investigator, would interfere with adherence to study requirements or a psychiatric disorder that is unstable or would preclude reliable participation in the study.
boolean
C0013222 (UMLS CUI [1,1])
C0521102 (UMLS CUI [1,2])
C0525058 (UMLS CUI [1,3])
C1510472 (UMLS CUI [2,1])
C0521102 (UMLS CUI [2,2])
C0525058 (UMLS CUI [2,3])
C0004936 (UMLS CUI [3,1])
C0443343 (UMLS CUI [3,2])
C0004936 (UMLS CUI [4,1])
C2348568 (UMLS CUI [4,2])
C0332196 (UMLS CUI [4,3])
Illness Serious Requirement Systemic therapy | Illness Serious Hospitalization Required | Diabetes Mellitus | Kidney Diseases | Heart Diseases | Lung diseases | Alcoholic Intoxication, Chronic | Impaired cognition Interferes with Protocol Compliance
Item
serious illness (requiring systemic treatment and/or hospitalization) such as diabetes mellitus, renal, cardiac, or pulmonary disease. subjects with a history of alcoholism, or in whom intellectual functioning is impaired sufficiently to interfere with the understanding of the protocol, or participation in the treatment and evaluation program.
boolean
C0221423 (UMLS CUI [1,1])
C0205404 (UMLS CUI [1,2])
C1514873 (UMLS CUI [1,3])
C1515119 (UMLS CUI [1,4])
C0221423 (UMLS CUI [2,1])
C0205404 (UMLS CUI [2,2])
C1708385 (UMLS CUI [2,3])
C0011849 (UMLS CUI [3])
C0022658 (UMLS CUI [4])
C0018799 (UMLS CUI [5])
C0024115 (UMLS CUI [6])
C0001973 (UMLS CUI [7])
C0338656 (UMLS CUI [8,1])
C0521102 (UMLS CUI [8,2])
C0525058 (UMLS CUI [8,3])