Age
Item
age between 19 and 60 years
boolean
C0001779 (UMLS CUI [1])
Multiple Sclerosis, Primary Progressive | Multiple Sclerosis, Secondary Progressive | Relapses Absent
Item
primary progressive ms or secondary progressive ms without relapses during the last one year
boolean
C0751964 (UMLS CUI [1])
C0751965 (UMLS CUI [2])
C0035020 (UMLS CUI [3,1])
C0332197 (UMLS CUI [3,2])
Disease length | Disability Progressive | Disease Progression EDSS | Disease Progression Pyramidal system | Disease Progression System Cerebellar | Disease Progression Brain Stem | Disease Progression Visual system | Disease Progression Sensory system function | Walking distance reduced | Hand function disability
Item
duration of the disease of at least 2 years clinical disability progression should have been observed in the 2 years prior to screening as per clinical judgment of the investigator. in addition, progression must be documented by an increase in the edss score of at least 0.5 points at any time during the 2 years prior to screening; or progression of 1 point in the pyramidal, cerebellar, brain stem , visual or sensory functional system during the last 2 years. should documented edss scores not be available, a written summary of the clinical evidence of disability progression in the previous 2 years must be submitted (for example walking distance or hand function).
boolean
C0872146 (UMLS CUI [1])
C0231170 (UMLS CUI [2,1])
C0205329 (UMLS CUI [2,2])
C0242656 (UMLS CUI [3,1])
C0451246 (UMLS CUI [3,2])
C0242656 (UMLS CUI [4,1])
C0228060 (UMLS CUI [4,2])
C0242656 (UMLS CUI [5,1])
C0449913 (UMLS CUI [5,2])
C0007765 (UMLS CUI [5,3])
C0242656 (UMLS CUI [6,1])
C0006121 (UMLS CUI [6,2])
C0242656 (UMLS CUI [7,1])
C3536733 (UMLS CUI [7,2])
C0242656 (UMLS CUI [8,1])
C0036658 (UMLS CUI [8,2])
C0424550 (UMLS CUI [9])
C0556293 (UMLS CUI [10])
EDSS
Item
edss (expanded disability status scale) 4.0-6.5
boolean
C0451246 (UMLS CUI [1])
MRI Criteria Fulfill | Multiple Sclerosis
Item
mri fulfilling the barkhof criteria for ms
boolean
C0024485 (UMLS CUI [1,1])
C0243161 (UMLS CUI [1,2])
C1550543 (UMLS CUI [1,3])
C0026769 (UMLS CUI [2])
Informed Consent
Item
written informed consent
boolean
C0021430 (UMLS CUI [1])
Pregnancy | Breast Feeding Period | Contraceptive methods Missing
Item
pregnancy or period of breastfeeding or missing adequate contraceptive protection
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2,1])
C1948053 (UMLS CUI [2,2])
C0700589 (UMLS CUI [3,1])
C1705492 (UMLS CUI [3,2])
Steroid therapy
Item
treatment with steroids in the last 30 days
boolean
C0149783 (UMLS CUI [1])
Interferons | glatiramer acetate | Immunoglobulins, Intravenous
Item
treatment with interferons, glatiramer acetate or ivig in the last1 month prior to enrolment
boolean
C0021747 (UMLS CUI [1])
C0289884 (UMLS CUI [2])
C0085297 (UMLS CUI [3])
Azathioprine | Mitoxantrone | Immunosuppressive Agents
Item
treatment with azathioprin, mitoxantrone or any other immuno-suppressive in the 6 months prior to enrolment
boolean
C0004482 (UMLS CUI [1])
C0026259 (UMLS CUI [2])
C0021081 (UMLS CUI [3])
Heart insuffiency New York Heart Association Classification | Cardiomyopathy | Cardiac Arrhythmia Treatment required for | Myocardial Ischemia Unstable CCS Class | Myocardial Ischemia Advanced CCS Class | Malignant Hypertension | Systolic Pressure | Diastolic blood pressure
Item
cardiac insufficiency (nyha iii/iv), cardiomyopathy, significant cardiac dysrhythmia requiring treatment, instable or advanced ischemic heart disease (ccs iii or iv), malignant hypertension (systolic > 180, diastolic > 110)
boolean
C0392173 (UMLS CUI [1,1])
C1275491 (UMLS CUI [1,2])
C0878544 (UMLS CUI [2])
C0003811 (UMLS CUI [3,1])
C0332121 (UMLS CUI [3,2])
C0151744 (UMLS CUI [4,1])
C0443343 (UMLS CUI [4,2])
C1879987 (UMLS CUI [4,3])
C0151744 (UMLS CUI [5,1])
C0205179 (UMLS CUI [5,2])
C1879987 (UMLS CUI [5,3])
C0020540 (UMLS CUI [6])
C0871470 (UMLS CUI [7])
C0428883 (UMLS CUI [8])
Hematological Disease
Item
history of any haematological disorder
boolean
C0018939 (UMLS CUI [1])
Renal Insufficiency
Item
history of renal insufficiency
boolean
C1565489 (UMLS CUI [1])
Mental condition Interferes with Study Subject Participation Status | Condition Interferes with Study Subject Participation Status | Mental condition Study Subject Participation Status Limited | Condition Study Subject Participation Status Limited
Item
any medical psychiatric or other circumstances which impede or restrict the subjects participation in the study in the manner intended
boolean
C3840291 (UMLS CUI [1,1])
C0521102 (UMLS CUI [1,2])
C2348568 (UMLS CUI [1,3])
C0348080 (UMLS CUI [2,1])
C0521102 (UMLS CUI [2,2])
C2348568 (UMLS CUI [2,3])
C3840291 (UMLS CUI [3,1])
C2348568 (UMLS CUI [3,2])
C0439801 (UMLS CUI [3,3])
C0348080 (UMLS CUI [4,1])
C2348568 (UMLS CUI [4,2])
C0439801 (UMLS CUI [4,3])
Medical contraindication MRI with contrast | Artificial cardiac pacemaker | Clip Aortic | Metallic implant
Item
contraindication for contrast enhanced mri (e.g. pace maker, aortic clip or any metal implant)
boolean
C1301624 (UMLS CUI [1,1])
C0202671 (UMLS CUI [1,2])
C0030163 (UMLS CUI [2])
C0175722 (UMLS CUI [3,1])
C0003483 (UMLS CUI [3,2])
C3693688 (UMLS CUI [4])