Multiple Myeloma | HLA Identical Sibling | Sibling Appropriate Peripheral Blood Stem Cell Donation | Induction Therapy | Thalidomide | Bortezomib | Lenalidomide
Item
1. newly diagnosed multiple myeloma patients with an hla identical sibling suitable for pbsc donation and treated in induction with thalidomide or bortezomib or lenalidomide conteining regimes.
boolean
C0026764 (UMLS CUI [1])
C0019721 (UMLS CUI [2,1])
C0205280 (UMLS CUI [2,2])
C0037047 (UMLS CUI [2,3])
C0037047 (UMLS CUI [3,1])
C1548787 (UMLS CUI [3,2])
C1518999 (UMLS CUI [3,3])
C0080231 (UMLS CUI [3,4])
C0600558 (UMLS CUI [4])
C0039736 (UMLS CUI [5])
C1176309 (UMLS CUI [6])
C1144149 (UMLS CUI [7])
Cytogenetic Analysis | del(13) FISH | del(17) FISH | t(4;14) FISH | t(11;14) FISH | t(14;16) FISH
Item
2. complete cytogenetic analysis at diagnosis, including fish analysis for chromosome deletions 13 and 17, and translocations (4;14) (11;14) and (14;16).
boolean
C0752095 (UMLS CUI [1])
C1517957 (UMLS CUI [2,1])
C0162789 (UMLS CUI [2,2])
C1517964 (UMLS CUI [3,1])
C0162789 (UMLS CUI [3,2])
C2986942 (UMLS CUI [4,1])
C0162789 (UMLS CUI [4,2])
C4287831 (UMLS CUI [5,1])
C0162789 (UMLS CUI [5,2])
C2986943 (UMLS CUI [6,1])
C0162789 (UMLS CUI [6,2])
Informed Consent
Item
3. the patient must have the capacity to give informed consent.
boolean
C0021430 (UMLS CUI [1])
Age
Item
4. age >18 and < 65
boolean
C0001779 (UMLS CUI [1])
Postmenopausal state | Female Sterilization | Gender Sexual Abstinence | Gender Contraceptive methods Double | Hormonal contraception | Intrauterine Devices | Vaginal contraceptive diaphragm | Vaginal Spermicides | Female Condoms
Item
5. if female, the patient is either postmenopausal since at least 24 consecutive months or surgically sterilized or she agrees to practice sexual abstinence or to use two reliable methods for contraception (e.g. a hormonal contraceptive, intra-uterine device, diaphragm with spermicide, condom with spermicide) for the duration of study
boolean
C0232970 (UMLS CUI [1])
C0015787 (UMLS CUI [2])
C0079399 (UMLS CUI [3,1])
C0036899 (UMLS CUI [3,2])
C0079399 (UMLS CUI [4,1])
C0700589 (UMLS CUI [4,2])
C0205173 (UMLS CUI [4,3])
C2985296 (UMLS CUI [5])
C0021900 (UMLS CUI [6])
C0042241 (UMLS CUI [7])
C0087145 (UMLS CUI [8])
C0221829 (UMLS CUI [9])
Gender Sexual Abstinence | Gender Latex condom | Partner Childbearing Potential
Item
6. if male, the patient agrees to practice sexual abstinence or to use a latex condom during any sexual contact with women of childbearing potential for the duration of study
boolean
C0079399 (UMLS CUI [1,1])
C0036899 (UMLS CUI [1,2])
C0079399 (UMLS CUI [2,1])
C3873750 (UMLS CUI [2,2])
C0682323 (UMLS CUI [3,1])
C3831118 (UMLS CUI [3,2])
Pregnancy test negative
Item
7. negative pregnancy test
boolean
C0427780 (UMLS CUI [1])
Karnofsky Performance Status | Exception Due to Multiple Myeloma
Item
1. karnofsky score less than 60 (see appendix c), unless due solely to myeloma
boolean
C0206065 (UMLS CUI [1])
C1705847 (UMLS CUI [2,1])
C0678226 (UMLS CUI [2,2])
C0026764 (UMLS CUI [2,3])
Left ventricular ejection fraction | Coronary Artery Disease Symptomatic | Heart failure Treatment required for
Item
2. left ventricular ejection fraction less than 40%, or symptomatic coronary artery disease or other cardiac failure requiring therapy
boolean
C0428772 (UMLS CUI [1])
C1956346 (UMLS CUI [2,1])
C0231220 (UMLS CUI [2,2])
C0018801 (UMLS CUI [3,1])
C0332121 (UMLS CUI [3,2])
Elevated total bilirubin | Alanine aminotransferase increased | Aspartate aminotransferase increased
Item
3. bilirubin greater than 2 x the upper limit of normal, or sgpt and sgot > 4 x the upper limit of normal
boolean
C0741494 (UMLS CUI [1])
C0151905 (UMLS CUI [2])
C0151904 (UMLS CUI [3])
Carbon Monoxide Diffusing Capability Test Corrected | Supplemental oxygen
Item
4. dlco < 40% (corrected) or receiving continuous supplemental oxygen.
boolean
C1516251 (UMLS CUI [1,1])
C0205202 (UMLS CUI [1,2])
C4534306 (UMLS CUI [2])
Creatinine clearance measurement | Autografting Evaluation Initial
Item
5. creatinine clearance < 40 cc/min at the time of initial autografting evaluation.
boolean
C0373595 (UMLS CUI [1])
C0040736 (UMLS CUI [2,1])
C1261322 (UMLS CUI [2,2])
C0205265 (UMLS CUI [2,3])
Poor hypertension control
Item
6. patients with poorly controlled hypertension
boolean
C0421190 (UMLS CUI [1])
Non-Hematologic Malignancy | Exception Skin carcinoma
Item
7. patients with active non-hematologic malignancies (except non-melanoma skin cancers).
boolean
C0935681 (UMLS CUI [1])
C1705847 (UMLS CUI [2,1])
C0699893 (UMLS CUI [2,2])
Non-Hematologic Malignancy | Exception Skin carcinoma | In complete remission | Risk Percentage Disease recurrence
Item
8. patients with a history of non-hematologic malignancies (except non-melanoma skin cancers) currently in a complete remission, who are less than 5 years from the time of complete remission, and have a >20% risk of disease recurrence
boolean
C0935681 (UMLS CUI [1])
C1705847 (UMLS CUI [2,1])
C0699893 (UMLS CUI [2,2])
C0677874 (UMLS CUI [3])
C0035647 (UMLS CUI [4,1])
C0439165 (UMLS CUI [4,2])
C0679254 (UMLS CUI [4,3])
HIV Seropositivity
Item
9. seropositive for hiv
boolean
C0019699 (UMLS CUI [1])
Fertility Contraceptive methods Unwilling
Item
10. fertile men or women unwilling to use contraceptive techniques during and for 12 months following treatment.
boolean
C0015895 (UMLS CUI [1,1])
C0700589 (UMLS CUI [1,2])
C0558080 (UMLS CUI [1,3])
Toxicity Evaluation | Evaluation Patient Tolerable Lenalidomide | Status post Allografting
Item
11. to evaluate toxicity and tolerability of lenalidomide after allografting
boolean
C0600688 (UMLS CUI [1,1])
C1261322 (UMLS CUI [1,2])
C1261322 (UMLS CUI [2,1])
C0030705 (UMLS CUI [2,2])
C4053931 (UMLS CUI [2,3])
C1144149 (UMLS CUI [2,4])
C0231290 (UMLS CUI [3,1])
C0040739 (UMLS CUI [3,2])
Evaluation Effectiveness Lenalidomide | Induction Complete remission | Status post Allografting
Item
12. to evaluate efficacy of lenalidomide in inducing complete remission 12 months after allografting
boolean
C1261322 (UMLS CUI [1,1])
C1280519 (UMLS CUI [1,2])
C1144149 (UMLS CUI [1,3])
C0205263 (UMLS CUI [2,1])
C0677874 (UMLS CUI [2,2])
C0231290 (UMLS CUI [3,1])
C0040739 (UMLS CUI [3,2])