Multiple Myeloma
Item
confirmed diagnosis of multiple myeloma
boolean
C0026764 (UMLS CUI [1])
Bortezomib | Velcade
Item
received prior courses of bortezomib (velcade)-based therapy
boolean
C1176309 (UMLS CUI [1])
C1174739 (UMLS CUI [2])
M Protein Percentage Reduction | Disease Progression Absent | Velcade
Item
greater than or equal to 50% reduction in m-protein sustained for a minimum of 60 days and no evidence of progression of disease while on the most recent course of velcade-based therapy
boolean
C0700271 (UMLS CUI [1,1])
C0439165 (UMLS CUI [1,2])
C0392756 (UMLS CUI [1,3])
C0242656 (UMLS CUI [2,1])
C0332197 (UMLS CUI [2,2])
C1174739 (UMLS CUI [3])
Velcade Dose
Item
60 days or more since the patient's last velcade dose
boolean
C1174739 (UMLS CUI [1,1])
C0178602 (UMLS CUI [1,2])
Life Expectancy
Item
life expectancy > 3 months
boolean
C0023671 (UMLS CUI [1])
Progressive Disease | Lytic lesion New | Lytic lesion Worsening | Plasmacytoma | Hypercalcemia | M Protein Increase Percentage
Item
progressive disease defined by new or worsening lytic bone lesions or plasmacytoma or hypercalcemia or a >25% increase in m-protein
boolean
C1335499 (UMLS CUI [1])
C0221204 (UMLS CUI [2,1])
C0205314 (UMLS CUI [2,2])
C0221204 (UMLS CUI [3,1])
C0332271 (UMLS CUI [3,2])
C0032131 (UMLS CUI [4])
C0020437 (UMLS CUI [5])
C0700271 (UMLS CUI [6,1])
C0442805 (UMLS CUI [6,2])
C0439165 (UMLS CUI [6,3])
Progressive Disease | Anthracyclines
Item
no patients with progressive disease while receiving an anthracycline-based regimen
boolean
C1335499 (UMLS CUI [1])
C0282564 (UMLS CUI [2])
Prior Therapy Quantity Multiple Myeloma
Item
no patients with >2 prior regimens for the treatment of multiple myeloma
boolean
C1514463 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
C0026764 (UMLS CUI [1,3])
Major surgery
Item
no major surgery within 2 weeks before screening
boolean
C0679637 (UMLS CUI [1])
Allergic Reaction Boron Compounds | Mannitol allergy | Allergic Reaction Anthracyclines | Allergic Reaction Liposomal agent
Item
no patients with history of allergic reaction to compounds containing boron, mannitol, anthracycline, or liposomal formulations of any agent
boolean
C1527304 (UMLS CUI [1,1])
C0006031 (UMLS CUI [1,2])
C0571922 (UMLS CUI [2])
C1527304 (UMLS CUI [3,1])
C0282564 (UMLS CUI [3,2])
C1527304 (UMLS CUI [4,1])
C1532143 (UMLS CUI [4,2])
HIV Seropositivity
Item
no patients known to be human immunodeficiency virus (hiv) positive
boolean
C0019699 (UMLS CUI [1])
Poor hypertension control | Diabetes mellitus poor control | Illness Serious | Serious mental illness
Item
no patients with poorly controlled hypertension, diabetes mellitus, or other serious medical or psychiatric illness
boolean
C0421190 (UMLS CUI [1])
C0860161 (UMLS CUI [2])
C0221423 (UMLS CUI [3,1])
C0205404 (UMLS CUI [3,2])
C3841614 (UMLS CUI [4])
Sepsis Treatment required for
Item
no patients with an active systemic infection requiring treatment
boolean
C0243026 (UMLS CUI [1,1])
C0332121 (UMLS CUI [1,2])