Therapeutic radiology procedure | Immunotherapy | Chemotherapy | Biological Factors | G-CSF | Investigational New Drugs Adverse effects | Recovery Lacking | Investigational New Drugs Other | Allergic Reaction Compound P276-00 Similar | Myocardial Infarction | Cardiac dysfunction Uncontrolled | Malignant Neoplasms | Exception Basal cell carcinoma Treated | Exception Squamous cell carcinoma of skin Treated | Exception Carcinoma in situ of uterine cervix Treated | Exception Carcinoma in situ of female breast Treated | Exception Carcinoma in situ of prostate Treated | Exception Disease Free of | Comorbidity Uncontrolled | Communicable Disease | Symptomatic congestive heart failure | Cardiac ejection fraction | Angina, Unstable | Cardiac Arrhythmia | Mental disorders Protocol Compliance Limited | Social situation Protocol Compliance Limited | Pregnancy | Breast Feeding | HIV Seropositivity | Pharmaceutical Preparations Causing Prolonged QT interval | Pharmaceutical Preparations Causing Prolonged QTc interval | Pharmaceutical Preparations Causing Torsades de Pointes | Condition Study Subject Participation Status At risk | Laboratory test result abnormal Study Subject Participation Status At risk
Item
1. subjects having received radiotherapy, immunotherapy, chemotherapy and or biological agents like g-csf in the 2 weeks prior to day 1 of study drug administration and have not recovered completely from the side effects of the earlier investigational agent 2. subjects having received any other investigational agents within 2 weeks prior to the date of enrolment 3. history of allergic reactions attributed to compounds of similar chemical composition to p276-00 4. subjects with a history of myocardial infarction or uncontrolled cardiac dysfunction during the previous 6 months 5. prior malignancy (within the last 3 years) except for adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer, in situ breast cancer, in situ prostate cancer or any other cancer for which the subject has been disease-free for at least 3 years 6. subjects with uncontrolled inter-current illness including, but not limited to ongoing or active infection, symptomatic congestive heart failure, known cardiac ejection fraction <40%, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements 7. women who are pregnant or nursing 8. subjects known to be seropositive for the human immunodeficiency virus 9. subjects requiring the use of concomitant medications that prolong the qt/qtc interval and/or are known to cause torsades de pointes (tdp) 10. any condition, including laboratory abnormalities, that in the opinion of the investigator places the subject at unacceptable risk if he/she were to participate in the study
boolean
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