Adenocarcinoma of colon metastatic | Adenocarcinoma of rectum metastatic
Item
histologically or cytologically confirmed metastatic adenocarcinoma of the colon or rectum.
boolean
C4324497 (UMLS CUI [1])
C0149978 (UMLS CUI [2,1])
C1522484 (UMLS CUI [2,2])
Measurable Disease | Non-Measurable Lesion
Item
subjects with measurable or unmeasurable disease
boolean
C1513041 (UMLS CUI [1])
C1334988 (UMLS CUI [2])
ECOG performance status
Item
eastern cooperative oncology group (ecog) score of 0 or 1
boolean
C1520224 (UMLS CUI [1])
Age
Item
men or women at least 18 years of age
boolean
C0001779 (UMLS CUI [1])
Hematologic function | Renal function | Liver function | Coagulation function analysis
Item
adequate hematologic, renal, hepatic and coagulation function
boolean
C0221130 (UMLS CUI [1])
C0232804 (UMLS CUI [2])
C0232741 (UMLS CUI [3])
C3516400 (UMLS CUI [4])
CNS metastases
Item
history or known presence of central nervous system (cns) metastases
boolean
C0686377 (UMLS CUI [1])
Prior Chemotherapy Colorectal Carcinoma Advanced | Systemic therapy Colorectal Carcinoma Advanced | Prior Chemotherapy Colorectal Carcinoma metastatic | Systemic therapy Colorectal Carcinoma metastatic
Item
prior chemotherapy or other systemic therapy for advanced or metastatic crc
boolean
C1514457 (UMLS CUI [1,1])
C0009402 (UMLS CUI [1,2])
C0205179 (UMLS CUI [1,3])
C1515119 (UMLS CUI [2,1])
C0009402 (UMLS CUI [2,2])
C0205179 (UMLS CUI [2,3])
C1514457 (UMLS CUI [3,1])
C0009402 (UMLS CUI [3,2])
C1522484 (UMLS CUI [3,3])
C1515119 (UMLS CUI [4,1])
C0009402 (UMLS CUI [4,2])
C1522484 (UMLS CUI [4,3])
Investigational New Drugs Colorectal Carcinoma Advanced | Investigational New Drugs Colorectal Carcinoma metastatic | Investigational Therapy Colorectal Carcinoma Advanced | Investigational Therapy Colorectal Carcinoma metastatic
Item
any investigational agent or therapy for advanced or metastatic crc
boolean
C0013230 (UMLS CUI [1,1])
C0009402 (UMLS CUI [1,2])
C0205179 (UMLS CUI [1,3])
C0013230 (UMLS CUI [2,1])
C0009402 (UMLS CUI [2,2])
C1522484 (UMLS CUI [2,3])
C0949266 (UMLS CUI [3,1])
C0009402 (UMLS CUI [3,2])
C0205179 (UMLS CUI [3,3])
C0949266 (UMLS CUI [4,1])
C0009402 (UMLS CUI [4,2])
C1522484 (UMLS CUI [4,3])
Heart Disease
Item
clinically significant cardiac disease
boolean
C0018799 (UMLS CUI [1])
Peripheral Neuropathy
Item
clinically significant peripheral neuropathy
boolean
C0031117 (UMLS CUI [1])
Inflammatory Bowel Disease
Item
active inflammatory bowel disease
boolean
C0021390 (UMLS CUI [1])
Gastrointestinal ulcer | Hemorrhage
Item
recent gastrointestinal ulcer or hemorrhage
boolean
C0237938 (UMLS CUI [1])
C0019080 (UMLS CUI [2])
Arterial thrombosis | Pulmonary Embolism
Item
recent arterial thrombotic event or pulmonary embolus
boolean
C0151942 (UMLS CUI [1])
C0034065 (UMLS CUI [2])
Hemorrhage | Bleeding tendency | Blood Coagulation Disorders
Item
recent history of clinically significant bleeding, bleeding diathesis, or coagulopathy
boolean
C0019080 (UMLS CUI [1])
C1458140 (UMLS CUI [2])
C0005779 (UMLS CUI [3])
Major surgery | Major surgery Recovery Lacking
Item
recent major surgical procedure or not yet recovered from major surgery
boolean
C0679637 (UMLS CUI [1])
C0679637 (UMLS CUI [2,1])
C2004454 (UMLS CUI [2,2])
C0332268 (UMLS CUI [2,3])