Colorectal cancer metastatic | Neoplasm Metastasis Resectable Evidence Minimal | Neoplasm Metastasis Extrahepatic
Item
histologically or cytologically confirmed metastatic colorectal cancer with minimal evidence of disease or resectable metastases (to include extra-hepatic metastases).
boolean
C0948380 (UMLS CUI [1])
C0027627 (UMLS CUI [2,1])
C1514888 (UMLS CUI [2,2])
C3887511 (UMLS CUI [2,3])
C0547040 (UMLS CUI [2,4])
C0027627 (UMLS CUI [3,1])
C1517058 (UMLS CUI [3,2])
Availability of Tumor tissue sample metastatic | Availability of Secondary malignant neoplasm of liver Specimen | Availability of Specimen Site Additional | Autogenous vaccine preparation
Item
availability of metastatic tumor material, from hepatic metastasis and additional sites, that can be resected under sterile conditions for autologous vaccine preparation (not all tumors harvested will be of sufficient quantity or quality to make vaccine, therefore some subjects may not receive vaccine).
boolean
C0470187 (UMLS CUI [1,1])
C0475358 (UMLS CUI [1,2])
C1522484 (UMLS CUI [1,3])
C0470187 (UMLS CUI [2,1])
C0494165 (UMLS CUI [2,2])
C0370003 (UMLS CUI [2,3])
C0470187 (UMLS CUI [3,1])
C0370003 (UMLS CUI [3,2])
C1515974 (UMLS CUI [3,3])
C1524062 (UMLS CUI [3,4])
C0201667 (UMLS CUI [4])
Absence Chemotherapy Malignant Neoplasms | Absence Therapeutic radiology procedure Malignant Neoplasms | Absence Major surgery Malignant Neoplasms | Absence Biological treatment Malignant Neoplasms | Side effects Patient recovered
Item
no chemotherapy, radiotherapy, major surgery, or biologic therapy for their malignancy in the 4 weeks prior to the vaccine administration and must have recovered from all side effects.
boolean
C0332197 (UMLS CUI [1,1])
C0392920 (UMLS CUI [1,2])
C0006826 (UMLS CUI [1,3])
C0332197 (UMLS CUI [2,1])
C1522449 (UMLS CUI [2,2])
C0006826 (UMLS CUI [2,3])
C0332197 (UMLS CUI [3,1])
C0679637 (UMLS CUI [3,2])
C0006826 (UMLS CUI [3,3])
C0332197 (UMLS CUI [4,1])
C1531518 (UMLS CUI [4,2])
C0006826 (UMLS CUI [4,3])
C0879626 (UMLS CUI [5,1])
C1115804 (UMLS CUI [5,2])
ECOG performance status
Item
an ecog performance standard of 0, 1 or 2.
boolean
C1520224 (UMLS CUI [1])
Liver function | Serum total bilirubin measurement | Prothrombin time assay
Item
adequate hepatic function as evidenced by bilirubin < 2.0 mg/dl and a pt < 2 seconds of the upper limit of normal.
boolean
C0232741 (UMLS CUI [1])
C1278039 (UMLS CUI [2])
C0033707 (UMLS CUI [3])
Age | Body Weight
Item
age equal to 18 years or older and greater than 30 kg.
boolean
C0001779 (UMLS CUI [1])
C0005910 (UMLS CUI [2])
Platelet Count measurement | Hematocrit level | White Blood Cell Count procedure | Creatinine measurement, serum | Creatinine clearance measurement
Item
platelet counts greater than 100,000, a hematocrit > 27.0, a white blood count > 3000/µl, and a creatinine less than or equal to 1.5 mg/dl or a creatinine clearance of > 60 ml/min.
boolean
C0032181 (UMLS CUI [1])
C0518014 (UMLS CUI [2])
C0023508 (UMLS CUI [3])
C0201976 (UMLS CUI [4])
C0373595 (UMLS CUI [5])
Awareness Neoplastic disease | Awareness Investigational Therapy | Awareness Alternative medical treatment | Awareness Risks and Benefits | Informed Consent Willing
Item
aware of the neoplastic nature of his/her illness, the experimental nature of the therapy, alternative treatments, potential benefits and risks, and willing to sign an informed consent.
boolean
C0004448 (UMLS CUI [1,1])
C1882062 (UMLS CUI [1,2])
C0004448 (UMLS CUI [2,1])
C0949266 (UMLS CUI [2,2])
C0004448 (UMLS CUI [3,1])
C0683466 (UMLS CUI [3,2])
C0004448 (UMLS CUI [4,1])
C0687742 (UMLS CUI [4,2])
C0021430 (UMLS CUI [5,1])
C0600109 (UMLS CUI [5,2])
Informed Consent
Item
patients must be able to understand and be willing to sign a written informed consent document.
boolean
C0021430 (UMLS CUI [1])
Immunosuppressive Agents Systemic | Systemic steroids | Eligibility Steroids Adrenal gland hypofunction
Item
subjects currently treated with systemic immunosuppressive agents, including steroids, are ineligible until 4 weeks after removal from immunosuppressive treatment. subjects on maintenance steroids because of adrenal insufficiency are eligible.
boolean
C0021081 (UMLS CUI [1,1])
C0205373 (UMLS CUI [1,2])
C2825233 (UMLS CUI [2])
C1548635 (UMLS CUI [3,1])
C0038317 (UMLS CUI [3,2])
C0001623 (UMLS CUI [3,3])
Liver function tests abnormal Severe | Aspartate aminotransferase increased | Alanine aminotransferase increased | Gamma-glutamyl transferase raised | Serum alkaline phosphatase raised | Serum lactic dehydrogenase increased | Elevated total bilirubin
Item
subjects with severely abnormal liver function tests [ast (sgot), alt (sgpt), ggt, alk.phos, ldh, and total bilirubin greater than 2 x uln]
boolean
C0151766 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
C0151904 (UMLS CUI [2])
C0151905 (UMLS CUI [3])
C0151662 (UMLS CUI [4])
C1314665 (UMLS CUI [5])
C0750858 (UMLS CUI [6])
C0741494 (UMLS CUI [7])
Uncontrolled pain
Item
subjects with uncontrolled pain.
boolean
C0747149 (UMLS CUI [1])
Autoimmune Diseases | HIV Seropositivity | Serology positive Hepatitis B Virus | Serology positive Hepatitis C virus | Blood donor Testing
Item
subjects with active autoimmune disease, positive serology for hiv, hbv, or hcv (testing will be performed with fda licensed blood donor tests).
boolean
C0004364 (UMLS CUI [1])
C0019699 (UMLS CUI [2])
C0242089 (UMLS CUI [3,1])
C0019169 (UMLS CUI [3,2])
C0242089 (UMLS CUI [4,1])
C0220847 (UMLS CUI [4,2])
C0005795 (UMLS CUI [5,1])
C0039593 (UMLS CUI [5,2])
Malignant Neoplasms Additional | Exception Skin carcinoma | Exception Carcinoma in situ of uterine cervix
Item
subjects with concurrent additional malignancy (with exception of non-melanoma skin cancers and carcinoma in situ of the cervix).
boolean
C0006826 (UMLS CUI [1,1])
C1524062 (UMLS CUI [1,2])
C1705847 (UMLS CUI [2,1])
C0699893 (UMLS CUI [2,2])
C1705847 (UMLS CUI [3,1])
C0851140 (UMLS CUI [3,2])
Heparin allergy
Item
subjects who are allergic to or develop an allergy to heparin.
boolean
C0571776 (UMLS CUI [1])
Pregnancy
Item
subjects who are pregnant.
boolean
C0032961 (UMLS CUI [1])
Hypersensitivity Local Anesthetics
Item
subjects who have sensitivity to drugs that provide local anesthesia.
boolean
C0020517 (UMLS CUI [1,1])
C0002934 (UMLS CUI [1,2])