Secondary malignant neoplasm of female breast Measurable | Non-Measurable Lesion Serum CA 27-29 Measurement | Non-Measurable Lesion Serum Mucin-1 Measurement
Item
has mbc that is measurable by recist or has nonmeasurable disease with serum ca27.29 (or ca15.3) ≥ 50
boolean
C0346993 (UMLS CUI [1,1])
C1513040 (UMLS CUI [1,2])
C1334988 (UMLS CUI [2,1])
C0229671 (UMLS CUI [2,2])
C0291672 (UMLS CUI [2,3])
C0242485 (UMLS CUI [2,4])
C1334988 (UMLS CUI [3,1])
C0229671 (UMLS CUI [3,2])
C0006611 (UMLS CUI [3,3])
C0242485 (UMLS CUI [3,4])
Breast Carcinoma HER2 negative
Item
has human epidermal growth factor receptor 2 (her2) negative breast cancer
boolean
C0678222 (UMLS CUI [1,1])
C4087376 (UMLS CUI [1,2])
Prior Chemotherapy Quantity
Item
prior chemotherapy is permitted with no limit on the number of prior regimens
boolean
C1514457 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
Elapsed Time Since Chemotherapy | Elapsed Time Since Therapeutic radiology procedure
Item
two weeks or more have elapsed since last chemotherapy or radiation treatment
boolean
C2826303 (UMLS CUI [1,1])
C1711239 (UMLS CUI [1,2])
C0392920 (UMLS CUI [1,3])
C2826303 (UMLS CUI [2,1])
C1711239 (UMLS CUI [2,2])
C1522449 (UMLS CUI [2,3])
ECOG performance status
Item
has an eastern cooperative oncology group (ecog) performance status (ps) of 0-2
boolean
C1520224 (UMLS CUI [1])
Gender | Age
Item
is female, ≥ 18 yrs of age
boolean
C0079399 (UMLS CUI [1])
C0001779 (UMLS CUI [2])
Laboratory Results Appropriate Study Protocol
Item
protocol defined appropriate laboratory values
boolean
C1254595 (UMLS CUI [1,1])
C1548787 (UMLS CUI [1,2])
C2348563 (UMLS CUI [1,3])
Pregnancy test negative
Item
negative pregnancy test within 7 calendar days prior to registration
boolean
C0427780 (UMLS CUI [1])
Informed Consent
Item
has signed a patient informed consent
boolean
C0021430 (UMLS CUI [1])
Ixabepilone | Epothilones
Item
had prior treatment with ixabepilone or other epothilones
boolean
C1135132 (UMLS CUI [1])
C1136012 (UMLS CUI [2])
Disease HER2 Positive
Item
has her2+ disease
boolean
C0012634 (UMLS CUI [1,1])
C2348909 (UMLS CUI [1,2])
Hypersensitivity CTCAE Grades Cremophor EL
Item
has a known, prior, severe (national cancer institute common terminology criteria adverse events [nci ctcae] grade 3-4) history of hypersensitivity reaction to a drug formulated in cremophor ® el (polyoxyethylated castor oil)
boolean
C0020517 (UMLS CUI [1,1])
C1516728 (UMLS CUI [1,2])
C0056476 (UMLS CUI [1,3])
Immunotherapy | Hormone Therapy | Therapeutic radiology procedure
Item
is receiving concurrent immunotherapy, hormonal therapy or radiation therapy
boolean
C0021083 (UMLS CUI [1])
C0279025 (UMLS CUI [2])
C1522449 (UMLS CUI [3])
Therapy, investigational
Item
is receiving concurrent investigational therapy or has received such therapy within the past 30 days
boolean
C0949266 (UMLS CUI [1])
Peripheral Neuropathy CTCAE Grades
Item
has peripheral neuropathy > grade 1
boolean
C0031117 (UMLS CUI [1,1])
C1516728 (UMLS CUI [1,2])
Central Nervous System Involvement Requirement Therapeutic radiology procedure | Central Nervous System Involvement Requirement Steroids | Eligibility Metastatic malignant neoplasm to brain Stable | Relationship Steroids Free of
Item
has evidence of central nervous system (cns) involvement requiring radiation or steroid treatment. participants with stable brain metastases who are off steroids at least 2 weeks are eligible
boolean
C4050309 (UMLS CUI [1,1])
C1514873 (UMLS CUI [1,2])
C1522449 (UMLS CUI [1,3])
C4050309 (UMLS CUI [2,1])
C1514873 (UMLS CUI [2,2])
C0038317 (UMLS CUI [2,3])
C1548635 (UMLS CUI [3,1])
C0220650 (UMLS CUI [3,2])
C0205360 (UMLS CUI [3,3])
C0439849 (UMLS CUI [4,1])
C0038317 (UMLS CUI [4,2])
C0332296 (UMLS CUI [4,3])
Pregnancy | Breast Feeding
Item
is pregnant or breast feeding
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])