Age
Item
62 years of age or older
boolean
C0001779 (UMLS CUI [1])
Major Depressive Disorder Inventory of Depressive Symptomatology Self-Report Version Questionnaire
Item
meet the dsm-iv diagnosis of mdd based on sheehan's mini-international neuropsychiatric interview (mini), with a score of > 28 on the 30-item inventory of depressive symptomatology - self rated version (ids-sr30)
boolean
C1269683 (UMLS CUI [1,1])
C4330497 (UMLS CUI [1,2])
Illness Unstable Preventing Completion of clinical trial | Physical Examination | Electrocardiography | Laboratory Procedures Safety | Review of systems
Item
subjects will have no unstable medical illness that would prevent completion of participation in the trial, determined as needed from physical examination, ecg, laboratory safety tests, as well as a review of systems
boolean
C0221423 (UMLS CUI [1,1])
C0443343 (UMLS CUI [1,2])
C1292733 (UMLS CUI [1,3])
C2732579 (UMLS CUI [1,4])
C0031809 (UMLS CUI [2])
C0013798 (UMLS CUI [3])
C0022885 (UMLS CUI [4,1])
C0036043 (UMLS CUI [4,2])
C0489633 (UMLS CUI [5])
Legal capacity Lacking | Mental handicap | Informed Consent Unable
Item
mentally or legally incapacitated, unable to give informed consent
boolean
C0683673 (UMLS CUI [1,1])
C0332268 (UMLS CUI [1,2])
C1306341 (UMLS CUI [2])
C0021430 (UMLS CUI [3,1])
C1299582 (UMLS CUI [3,2])
Anorexia Nervosa | Bulimia Nervosa | Obsessive-Compulsive Disorder | Cognition Disorders | Bipolar Disorder | Psychotic Disorders | Major depression with psychotic features
Item
meets dsm-iv criteria for anorexia nervosa, bulimia nervosa, obsessive-compulsive disorder, any cognitive disorder, bipolar disorder, psychotic disorder, or major depression with psychotic features
boolean
C0003125 (UMLS CUI [1])
C2267227 (UMLS CUI [2])
C0028768 (UMLS CUI [3])
C0009241 (UMLS CUI [4])
C0005586 (UMLS CUI [5])
C0033975 (UMLS CUI [6])
C4518519 (UMLS CUI [7])
Mini-mental state examination
Item
mmse (folstein et al., 1975) score ≤ 24
boolean
C0451306 (UMLS CUI [1])
Drug Dependence | Substance Use Disorders
Item
evidence of drug dependency or substance abuse within the preceding nine months
boolean
C1510472 (UMLS CUI [1])
C0038586 (UMLS CUI [2])
Stable status | Remission | Psychotropic Drugs
Item
stable and in remission on current psychotropic medication(s)
boolean
C0205360 (UMLS CUI [1])
C0544452 (UMLS CUI [2])
C0033978 (UMLS CUI [3])
Electroconvulsive Therapy
Item
any ect within the past six months
boolean
C0013806 (UMLS CUI [1])
Intolerance to Escitalopram | Treatment failure Depressive episode | Escitalopram
Item
failure to tolerate esc or treatment failure with an adequate trial of esc in the current episode
boolean
C1744706 (UMLS CUI [1,1])
C1099456 (UMLS CUI [1,2])
C0162643 (UMLS CUI [2,1])
C0349217 (UMLS CUI [2,2])
C1099456 (UMLS CUI [3])
Medical contraindication Escitalopram | Hyponatremia Associated with Selective Serotonin Reuptake Inhibitors
Item
esc would be contraindicated (e.g., hyponatremia with a prior ssri)
boolean
C1301624 (UMLS CUI [1,1])
C1099456 (UMLS CUI [1,2])
C0020625 (UMLS CUI [2,1])
C0332281 (UMLS CUI [2,2])
C0360105 (UMLS CUI [2,3])
Fluoxetine | Monoamine Oxidase Inhibitors
Item
treatment with fluoxetine or an maoi within the past four weeks
boolean
C0016365 (UMLS CUI [1])
C0026457 (UMLS CUI [2])
Illness Severe Affecting Brain function | Illness Interferes with Interpretation Research results
Item
any medical illness severe enough to significantly affect brain function or to interfere with interpretation of study results
boolean
C0221423 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
C0392760 (UMLS CUI [1,3])
C0678908 (UMLS CUI [1,4])
C0221423 (UMLS CUI [2,1])
C0521102 (UMLS CUI [2,2])
C0459471 (UMLS CUI [2,3])
C0683954 (UMLS CUI [2,4])
Seizures | Operation on brain | Skull Fractures | Craniocerebral Trauma | Electroencephalogram abnormal
Item
history of seizures, brain surgery, skull fracture, significant head trauma, or abnormal eeg
boolean
C0036572 (UMLS CUI [1])
C0195775 (UMLS CUI [2])
C0037304 (UMLS CUI [3])
C0018674 (UMLS CUI [4])
C0151611 (UMLS CUI [5])
Indication Psychiatric hospitalization | DANGER OF HARM TO SELF | At risk of harming others
Item
psychiatric hospitalization indicated (e.g., imminent danger to self or others)
boolean
C3146298 (UMLS CUI [1,1])
C0748061 (UMLS CUI [1,2])
C0149660 (UMLS CUI [2])
C1271966 (UMLS CUI [3])
Electroencephalography Quantitative Unsuccessful | Biomarkers Determination Excluded
Item
initial qeeg recording is contaminated with artifact so that determination of the biomarker is precluded
boolean
C0013819 (UMLS CUI [1,1])
C0392762 (UMLS CUI [1,2])
C1272705 (UMLS CUI [1,3])
C0005516 (UMLS CUI [2,1])
C0521095 (UMLS CUI [2,2])
C0332196 (UMLS CUI [2,3])
Pharmaceutical Preparations Affecting Brain function | Antidepressive Agents | Anticonvulsants | Mood Stabilizer | Anticholinergic Agents | Antipsychotic Agents | Benzodiazepines
Item
use of medications known to affect brain function (e.g., antidepressants, anticonvulsants/mood stabilizers, anticholinergics, antipsychotics, benzodiazepines -
boolean
C0013227 (UMLS CUI [1,1])
C0392760 (UMLS CUI [1,2])
C0678908 (UMLS CUI [1,3])
C0003289 (UMLS CUI [2])
C0003286 (UMLS CUI [3])
C2917435 (UMLS CUI [4])
C0242896 (UMLS CUI [5])
C0040615 (UMLS CUI [6])
C0005064 (UMLS CUI [7])
Other Coding
Item
same list as in brite-md)
boolean
C3846158 (UMLS CUI [1])