Depressive disorder | Axis I diagnosis
Item
depression as diagnosed under dsm-iv axis i disorders.
boolean
C0011581 (UMLS CUI [1])
C0270287 (UMLS CUI [2])
Hamilton Depression Rating Scale 17 Item Clinical Classification
Item
score greater than 7 but less then 35 on the 17-item hamilton depression (ham-d) scale at screening.
boolean
C3639712 (UMLS CUI [1])
Availability of Relative Patient care
Item
the patient has relative(s) to care for him/her
boolean
C0470187 (UMLS CUI [1,1])
C0080103 (UMLS CUI [1,2])
C0017313 (UMLS CUI [1,3])
Informed Consent | Informed Consent Relative
Item
informed consent obtained from the patient or relative
boolean
C0021430 (UMLS CUI [1])
C0021430 (UMLS CUI [2,1])
C0080103 (UMLS CUI [2,2])
Hamilton rating scale for depression | Suicide attempt
Item
scores greater than 2 on the "suicide" item of ham-d, or history of suicide attempt(s) in the past 12 months.
boolean
C0451203 (UMLS CUI [1])
C0038663 (UMLS CUI [2])
At risk for suicide | At risk Homicide
Item
current suicidal or homicidal risk, as determined by the investigator.
boolean
C0563664 (UMLS CUI [1])
C1444641 (UMLS CUI [2,1])
C0019872 (UMLS CUI [2,2])
Liver diseases | Hepatitis | Liver Cirrhosis | Elevated liver enzymes
Item
clinically significant liver disease (such as hepatitis, cirrhosis, etc); or clinically significant elevation of liver enzyme tests (two times the upper limit of normal.
boolean
C0023895 (UMLS CUI [1])
C0019158 (UMLS CUI [2])
C0023890 (UMLS CUI [3])
C0235996 (UMLS CUI [4])
Epilepsy | Exception Febrile seizure
Item
history of seizure disorder (other than febrile).
boolean
C0014544 (UMLS CUI [1])
C1705847 (UMLS CUI [2,1])
C0009952 (UMLS CUI [2,2])
Monoamine Oxidase Inhibitors | Selective Serotonin Reuptake Inhibitors | Antidepressive Agents
Item
patient who has had monoamine oxidase inhibitor , any selective serotonin reuptake inhibitor or any other antidepressant in last 15 days
boolean
C0026457 (UMLS CUI [1])
C0360105 (UMLS CUI [2])
C0003289 (UMLS CUI [3])
Schizophrenia | Schizoaffective Disorder | Psychotic Disorders | Bipolar Disorder | Panic Disorder | Obsessive-Compulsive Disorder | Afffective Disorders Feature Psychotic | Mood Congruent | Mood Incongruent
Item
any of the following dsm-iv diagnoses current (within past 3 months) schizophrenia, schizo-affective, or other psychotic disorder; bipolar disorder; current panic disorder or obsessive compulsive disorder; history of psychotic features of affective disorder (mood congruent or incongruent)
boolean
C0036341 (UMLS CUI [1])
C0036337 (UMLS CUI [2])
C0033975 (UMLS CUI [3])
C0005586 (UMLS CUI [4])
C0030319 (UMLS CUI [5])
C0028768 (UMLS CUI [6])
C0525045 (UMLS CUI [7,1])
C2348519 (UMLS CUI [7,2])
C0033975 (UMLS CUI [7,3])
C0026516 (UMLS CUI [8,1])
C0439853 (UMLS CUI [8,2])
C0026516 (UMLS CUI [9,1])
C1321310 (UMLS CUI [9,2])
Thyroid Disease untreated | Thyroid Disease Unstable
Item
patient with history of untreated or unstable thyroid disorder
boolean
C0040128 (UMLS CUI [1,1])
C0332155 (UMLS CUI [1,2])
C0040128 (UMLS CUI [2,1])
C0443343 (UMLS CUI [2,2])
Antidepressant therapy Quantity | Response failed | Imipramine Dosage | Tricyclic Antidepressive Agents Equivalent | Phenelzine Dosage | Monoamine Oxidase Inhibitors Equivalent | Sertraline Dosage | Selective Serotonin Reuptake Inhibitors Equivalent
Item
failed to respond to at least two adequate antidepressant trials (defined as 6 weeks or more treatment with either greater than or equal to 150 mg imipramine, or tricyclic equivalent), or greater than or equal to 60 mg of phenelzine, or maoi equivalent, or greater than or equal to 100 mg of sertraline, or its ssri equivalent.
boolean
C1096649 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
C1704632 (UMLS CUI [2,1])
C0231175 (UMLS CUI [2,2])
C0020934 (UMLS CUI [3,1])
C0178602 (UMLS CUI [3,2])
C0003290 (UMLS CUI [4,1])
C0205163 (UMLS CUI [4,2])
C0031392 (UMLS CUI [5,1])
C0178602 (UMLS CUI [5,2])
C0026457 (UMLS CUI [6,1])
C0205163 (UMLS CUI [6,2])
C0074393 (UMLS CUI [7,1])
C0178602 (UMLS CUI [7,2])
C0360105 (UMLS CUI [8,1])
C0205163 (UMLS CUI [8,2])
Investigational New Drugs | Psychotropic Drugs
Item
have had other investigational drugs within 30 days or other psychotropic medication within 21 days.
boolean
C0013230 (UMLS CUI [1])
C0033978 (UMLS CUI [2])
Hypersensitivity Investigational New Drugs
Item
known allergy or hypersensitivity to the study medications.
boolean
C0020517 (UMLS CUI [1,1])
C0013230 (UMLS CUI [1,2])
Psychotherapy Specific Depressive disorder | Interpersonal psychotherapy
Item
receiving psychotherapies which are specifically designed to treat depression, eg, interpersonal psychotherapy during the study period.
boolean
C0033968 (UMLS CUI [1,1])
C0205369 (UMLS CUI [1,2])
C0011581 (UMLS CUI [1,3])
C0871787 (UMLS CUI [2])
Mental Retardation | Impaired cognition | Disease Interferes with Informed Consent | Disease Interferes with Protocol Compliance
Item
mental retardation or cognitive impairment, or any disorder that might interfere with their ability to give consent or follow study procedures and requirements.
boolean
C0025362 (UMLS CUI [1])
C0338656 (UMLS CUI [2])
C0012634 (UMLS CUI [3,1])
C0521102 (UMLS CUI [3,2])
C0021430 (UMLS CUI [3,3])
C0012634 (UMLS CUI [4,1])
C0521102 (UMLS CUI [4,2])
C0525058 (UMLS CUI [4,3])
Gender Sexual Abstinence | Gender Contraceptive methods
Item
in case of female patients, abstinence or effective method of contraception throughout the study
boolean
C0079399 (UMLS CUI [1,1])
C0036899 (UMLS CUI [1,2])
C0079399 (UMLS CUI [2,1])
C0700589 (UMLS CUI [2,2])