Adult | Age
Item
subjects will be adults, ages 18 to 75 years.
boolean
C0001675 (UMLS CUI [1])
C0001779 (UMLS CUI [2])
Informed Consent
Item
written informed consent
boolean
C0021430 (UMLS CUI [1])
Major Depressive Disorder
Item
mdd, current according to the fourth version of the diagnostic and statistical manual for mental disorders (dsm-iv)
boolean
C1269683 (UMLS CUI [1])
Hamilton Depression Rating Scale 17 Item Clinical Classification
Item
17-item hamilton depression rating scale (ham-d-17) score of > 14 at baseline.
boolean
C3639712 (UMLS CUI [1])
Antidepressive Agents Free of | Psychotropic Drugs Free of
Item
subjects who are not currently taking any antidepressant or other psychotropic medications and who have been free of these medications for 4 weeks prior to screening visit.
boolean
C0003289 (UMLS CUI [1,1])
C0332296 (UMLS CUI [1,2])
C0033978 (UMLS CUI [2,1])
C0332296 (UMLS CUI [2,2])
Pregnancy | Breast Feeding | Pregnancy, Planned
Item
women who are pregnant, lactating, or planning a pregnancy during the study.
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
C0032992 (UMLS CUI [3])
Childbearing Potential Contraceptive methods Absent | Oral contraception | Contraceptive implant | Female Condoms | Vaginal contraceptive diaphragm | Vaginal Spermicides | Intrauterine Devices | Tubal Ligation | Partner had vasectomy
Item
women of child bearing potential who are not using a medically accepted means of contraception (to include oral contraceptive or implant, condom, diaphragm, spermicide, intrauterine device, tubal ligation, or a partner with vasectomy).
boolean
C3831118 (UMLS CUI [1,1])
C0700589 (UMLS CUI [1,2])
C0332197 (UMLS CUI [1,3])
C0029151 (UMLS CUI [2])
C1657106 (UMLS CUI [3])
C0221829 (UMLS CUI [4])
C0042241 (UMLS CUI [5])
C0087145 (UMLS CUI [6])
C0021900 (UMLS CUI [7])
C0520483 (UMLS CUI [8])
C0420842 (UMLS CUI [9])
Mental disorders Uncontrolled
Item
any uncontrolled psychiatric disorder.
boolean
C0004936 (UMLS CUI [1,1])
C0205318 (UMLS CUI [1,2])
Psychotropic Drugs
Item
current use of psychotropic medications.
boolean
C0033978 (UMLS CUI [1])
Feature Psychotic Depressive episode | Feature Psychotic
Item
psychotic features in the current episode or a history of psychotic features.
boolean
C2348519 (UMLS CUI [1,1])
C0033975 (UMLS CUI [1,2])
C0349217 (UMLS CUI [1,3])
C2348519 (UMLS CUI [2,1])
C0033975 (UMLS CUI [2,2])
Substance Use Disorders | Substance Dependence
Item
alcohol or substance abuse or dependence within the past three months.
boolean
C0038586 (UMLS CUI [1])
C0038580 (UMLS CUI [2])
Craniocerebral Trauma | Epilepsy
Item
history of head trauma or seizure disorder.
boolean
C0018674 (UMLS CUI [1])
C0014544 (UMLS CUI [2])
Intolerance to Investigational New Drugs
Item
history of intolerance of the study medication.
boolean
C1744706 (UMLS CUI [1,1])
C0013230 (UMLS CUI [1,2])
Escitalopram Dosage | Disease Response failed
Item
failure to respond to escitalopram up to 20 mg for at least 6 weeks.
boolean
C1099456 (UMLS CUI [1,1])
C0178602 (UMLS CUI [1,2])
C1704632 (UMLS CUI [2,1])
C0231175 (UMLS CUI [2,2])
Antidepressant therapy Dose Quantity | Fluoxetine Dose Equivalent | Depressive episode Response failed
Item
failure to respond to 2 or more adequate antidepressant trials (6 weeks or longer on a therapeutic dose, equivalent to fluoxetine 40mg) in the current episode.
boolean
C1096649 (UMLS CUI [1,1])
C0178602 (UMLS CUI [1,2])
C1265611 (UMLS CUI [1,3])
C0016365 (UMLS CUI [2,1])
C0178602 (UMLS CUI [2,2])
C0205163 (UMLS CUI [2,3])
C0349217 (UMLS CUI [3,1])
C1704632 (UMLS CUI [3,2])
C0231175 (UMLS CUI [3,3])
Study Subject Participation Status | Psychotherapy Relationship Depression | Therapeutic procedure Discontinue Unwilling
Item
currently enrolled in other depression-focused psychotherapy and unwilling to cease treatment.
boolean
C2348568 (UMLS CUI [1])
C0033968 (UMLS CUI [2,1])
C0439849 (UMLS CUI [2,2])
C0011570 (UMLS CUI [2,3])
C0087111 (UMLS CUI [3,1])
C1444662 (UMLS CUI [3,2])
C0558080 (UMLS CUI [3,3])
Study Subject Inappropriate Cognitive Therapy | Study Subject Inappropriate Selective Serotonin Reuptake Inhibitors
Item
subjects who, per clinical judgment, are not appropriate candidates for cbt or ssris.
boolean
C0681850 (UMLS CUI [1,1])
C1548788 (UMLS CUI [1,2])
C0009244 (UMLS CUI [1,3])
C0681850 (UMLS CUI [2,1])
C1548788 (UMLS CUI [2,2])
C0360105 (UMLS CUI [2,3])
Mental disorders | Organic mental disorder | Schizophrenia | Schizoaffective Disorder | Delusional disorder | Psychotic Disorders | Bipolar Disorder | Feature Psychotic Mood Congruent | Feature Psychotic Mood Incongruent | Substance Dependence
Item
history or current diagnosis of the following dsm-iv psychiatric illness: organic mental disorder, schizophrenia, schizoaffective disorder, delusional disorder, psychotic disorders not otherwise specified, bipolar disorder, patients with mood congruent or mood incongruent psychotic features, patients with substance dependence disorders, including alcohol, active within the last 3 months.
boolean
C0004936 (UMLS CUI [1])
C0029227 (UMLS CUI [2])
C0036341 (UMLS CUI [3])
C0036337 (UMLS CUI [4])
C0011251 (UMLS CUI [5])
C0033975 (UMLS CUI [6])
C0005586 (UMLS CUI [7])
C2348519 (UMLS CUI [8,1])
C0033975 (UMLS CUI [8,2])
C0026516 (UMLS CUI [8,3])
C0439853 (UMLS CUI [8,4])
C2348519 (UMLS CUI [9,1])
C0033975 (UMLS CUI [9,2])
C0026516 (UMLS CUI [9,3])
C1321310 (UMLS CUI [9,4])
C0038580 (UMLS CUI [10])
At risk for suicide Serious Hamilton rating scale for depression | At risk Homicide Serious Hamilton rating scale for depression
Item
serious suicide or homicide risk, as assessed by the evaluating clinician or a score of 4 on the third item of the ham-d.
boolean
C0563664 (UMLS CUI [1,1])
C0205404 (UMLS CUI [1,2])
C0451203 (UMLS CUI [1,3])
C1444641 (UMLS CUI [2,1])
C0019872 (UMLS CUI [2,2])
C0205404 (UMLS CUI [2,3])
C0451203 (UMLS CUI [2,4])
Illness Serious | Illness Unstable | Cardiovascular Diseases | Liver diseases | Kidney Diseases | Respiration Disorders | Endocrine System Diseases | Nervous system disorder | Hematological Disease
Item
serious or unstable medical illness, including cardiovascular, hepatic, renal, respiratory, endocrine, neurologic or hematologic disease
boolean
C0221423 (UMLS CUI [1,1])
C0205404 (UMLS CUI [1,2])
C0221423 (UMLS CUI [2,1])
C0443343 (UMLS CUI [2,2])
C0007222 (UMLS CUI [3])
C0023895 (UMLS CUI [4])
C0022658 (UMLS CUI [5])
C0035204 (UMLS CUI [6])
C0014130 (UMLS CUI [7])
C0027765 (UMLS CUI [8])
C0018939 (UMLS CUI [9])