Major depressive episode Principal diagnosis
Item
suffers from a major depressive episode as the primary diagnosis according to diagnostic and statistical manual of mental disorders, 4th edition, text revision (dsm-iv-tr) criteria.
boolean
C0024517 (UMLS CUI [1,1])
C0332137 (UMLS CUI [1,2])
Major depressive episode Duration
Item
the reported duration of the current major depressive episode is at least 3 months.
boolean
C0024517 (UMLS CUI [1,1])
C0449238 (UMLS CUI [1,2])
Criteria Fulfill
Item
has 1 or more the following:
boolean
C0243161 (UMLS CUI [1,1])
C1550543 (UMLS CUI [1,2])
Mental disorder Any | Exception Major Depressive Disorder
Item
any current psychiatric disorder other than major depressive disorder as defined in the dsm-iv-tr.
boolean
C0004936 (UMLS CUI [1,1])
C1552551 (UMLS CUI [1,2])
C1705847 (UMLS CUI [2,1])
C1269683 (UMLS CUI [2,2])
Manic episode | Hypomanic episode | Schizophrenia | Psychotic Disorders | Major depression with psychotic features | Mental Retardation | Organic mental disorders | Mental disorders Due to Medical condition General
Item
current or past history of: manic or hypomanic episode, schizophrenia, or any other psychotic disorder, including major depression with psychotic features, mental retardation, organic mental disorders, or mental disorders due to a general medical condition as defined in the dsm-iv-tr.
boolean
C0349208 (UMLS CUI [1])
C1396834 (UMLS CUI [2])
C0036341 (UMLS CUI [3])
C0033975 (UMLS CUI [4])
C4518519 (UMLS CUI [5])
C0025362 (UMLS CUI [6])
C0029227 (UMLS CUI [7])
C0004936 (UMLS CUI [8,1])
C0678226 (UMLS CUI [8,2])
C3843040 (UMLS CUI [8,3])
C0205246 (UMLS CUI [8,4])
Substance Use Disorders | Exception Nicotine Use Disorder | Exception Caffeine related disorders
Item
any substance disorder (except nicotine and caffeine) within the previous 6 months as defined in the dsm-iv-tr.
boolean
C0038586 (UMLS CUI [1])
C1705847 (UMLS CUI [2,1])
C0376384 (UMLS CUI [2,2])
C1705847 (UMLS CUI [3,1])
C0236734 (UMLS CUI [3,2])
Nervous system disorder | Epilepsy
Item
presence or history of a clinically significant neurological disorder (including epilepsy).
boolean
C0027765 (UMLS CUI [1])
C0014544 (UMLS CUI [2])
Neurodegenerative Disorders | Alzheimer's Disease | Parkinson Disease | Multiple Sclerosis | Huntington Disease
Item
neurodegenerative disorder (alzheimer disease, parkinson disease, multiple sclerosis, huntington disease, etc).
boolean
C0524851 (UMLS CUI [1])
C0002395 (UMLS CUI [2])
C0030567 (UMLS CUI [3])
C0026769 (UMLS CUI [4])
C0020179 (UMLS CUI [5])
Axis II diagnosis compromises Clinical Trial
Item
any axis ii disorder that might compromise the study.
boolean
C0270288 (UMLS CUI [1,1])
C2945640 (UMLS CUI [1,2])
C0008976 (UMLS CUI [1,3])
At risk for suicide | Feeling suicidal Montgomery-Asberg Depression Rating Scale Questionnaire | Suicide attempt
Item
has a significant risk of suicide according to the investigator's opinion or has a score ≥5 on item 10 (suicidal thoughts) of the montgomery åsberg depression rating scale (madrs) or has made a suicide attempt in the previous 6 months.
boolean
C0563664 (UMLS CUI [1])
C0424000 (UMLS CUI [2,1])
C4054475 (UMLS CUI [2,2])
C0038663 (UMLS CUI [3])
Depressive Symptoms Resistant to Antidepressant therapy Quantity
Item
the current depressive symptoms of the patient are considered by the investigator to have been resistant to 2 adequate antidepressant treatments of at least 6 weeks duration each.
boolean
C0086132 (UMLS CUI [1,1])
C0332325 (UMLS CUI [1,2])
C1096649 (UMLS CUI [1,3])
C1265611 (UMLS CUI [1,4])
Electroconvulsive Therapy
Item
has received electroconvulsive therapy within 6 months prior to screening.
boolean
C0013806 (UMLS CUI [1])
Cognitive Therapy | Behavior Therapy | Psychotherapy systematic | Cognitive Therapy Planned | Behavior Therapy Planned | Psychotherapy systematic Planned
Item
is currently receiving formal cognitive or behavioral therapy, systematic psychotherapy, or plans to initiate such therapy during the study.
boolean
C0009244 (UMLS CUI [1])
C0004933 (UMLS CUI [2])
C0033968 (UMLS CUI [3,1])
C0220922 (UMLS CUI [3,2])
C0009244 (UMLS CUI [4,1])
C1301732 (UMLS CUI [4,2])
C0004933 (UMLS CUI [5,1])
C1301732 (UMLS CUI [5,2])
C0033968 (UMLS CUI [6,1])
C0220922 (UMLS CUI [6,2])
C1301732 (UMLS CUI [6,3])