Criteria Fulfill
Item
patients will be included if they:
boolean
C0243161 (UMLS CUI [1,1])
C1550543 (UMLS CUI [1,2])
Major depressive episode
Item
1. have a dsm-iv diagnosis of a major depressive episode (scid 11).
boolean
C0024517 (UMLS CUI [1])
Age
Item
2. aged 18-85.
boolean
C0001779 (UMLS CUI [1])
Depressive disorder Unresponsive to Treatment Other Coding | Clinical Response failed | Intolerance to Antidepressive Agents Dosage Sufficient
Item
3. have treatment resistant depression at stage ii of the thase and rush classification [31]; .e. have failed to achieve a clinical response, or did not tolerate, at least two separate antidepressant trials of sufficient dose for at least 6 weeks.
boolean
C0011581 (UMLS CUI [1,1])
C0205269 (UMLS CUI [1,2])
C3846158 (UMLS CUI [1,3])
C4055223 (UMLS CUI [2,1])
C0231175 (UMLS CUI [2,2])
C1744706 (UMLS CUI [3,1])
C0003289 (UMLS CUI [3,2])
C0178602 (UMLS CUI [3,3])
C0205410 (UMLS CUI [3,4])
Moderately severe depression Hamilton rating scale for depression | Group as study subject Illness Severe | Limitation Placebo Response rate | Transcranial Magnetic Stimulation, Repetitive
Item
4. have a hamilton depression rating scale score of > 20 (moderate - severe depression). including only a severely ill group of subjects limits the placebo response rate [32]. moreover, this will allow us to address the application of rtms methods in the most clinically relevant subgroup of patients (in addition helping to constrain group heterogeneity, a major issue in depression research).
boolean
C4304583 (UMLS CUI [1,1])
C0451203 (UMLS CUI [1,2])
C0681860 (UMLS CUI [2,1])
C0221423 (UMLS CUI [2,2])
C0205082 (UMLS CUI [2,3])
C0449295 (UMLS CUI [3,1])
C0032042 (UMLS CUI [3,2])
C0237629 (UMLS CUI [3,3])
C0872259 (UMLS CUI [4])
Absence Increase Antidepressive Agents | Absence Increase Psychotropic Drugs | Absence Antidepressive Agents New | Absence Psychotropic Drugs New
Item
5. have had no increase or initiation of new antidepressant (or other psychoactive) therapy in the 4 weeks prior to screening.
boolean
C0332197 (UMLS CUI [1,1])
C0442805 (UMLS CUI [1,2])
C0003289 (UMLS CUI [1,3])
C0332197 (UMLS CUI [2,1])
C0442805 (UMLS CUI [2,2])
C0033978 (UMLS CUI [2,3])
C0332197 (UMLS CUI [3,1])
C0003289 (UMLS CUI [3,2])
C0205314 (UMLS CUI [3,3])
C0332197 (UMLS CUI [4,1])
C0033978 (UMLS CUI [4,2])
C0205314 (UMLS CUI [4,3])
Medical condition Unstable | Nervous system disorder | Epilepsy | Pregnancy | Breast Feeding
Item
1. patients who have an unstable medical condition, neurological disorder or any history of a seizure disorder or are currently pregnant or lactating.
boolean
C3843040 (UMLS CUI [1,1])
C0443343 (UMLS CUI [1,2])
C0027765 (UMLS CUI [2])
C0014544 (UMLS CUI [3])
C0032961 (UMLS CUI [4])
C0006147 (UMLS CUI [5])
At risk for suicide | Requirement Electroconvulsive Therapy Immediate
Item
2. in the opinion of the investigator, are a sufficient suicidal risk to require immediate electro-convulsive therapy.
boolean
C0563664 (UMLS CUI [1])
C1514873 (UMLS CUI [2,1])
C0013806 (UMLS CUI [2,2])
C0205253 (UMLS CUI [2,3])
Substance Use Disorders | Substance Dependence | Personality Disorders | Axis I diagnosis
Item
3. have a current dsm iv diagnosis of substance abuse or dependence disorder, a diagnosis of a personality disorder (scid ii) or another axis 1 disorder.
boolean
C0038586 (UMLS CUI [1])
C0038580 (UMLS CUI [2])
C0031212 (UMLS CUI [3])
C0270287 (UMLS CUI [4])
Eligibility Criteria Heterogeneity Volunteer Sample
Item
please note: several of these criteria (e.g. inclusion criteria 1 & 2, exclusion criteria 3) have been selected to explicitly constrain the heterogeneity of the sample to increase the likely power of the study to detect differences between the groups given the potentially subtle difference between the treatment methods.
boolean
C1516637 (UMLS CUI [1,1])
C0019409 (UMLS CUI [1,2])
C0150095 (UMLS CUI [1,3])