Outpatients | Age
Item
male and female outpatients aged 18-65 years.
boolean
C0029921 (UMLS CUI [1])
C0001779 (UMLS CUI [2])
Major Depressive Disorder
Item
patients will meet dsm-iv criteria for major depressive disorder as determined by the mood disorders section of the mini international neuropsychiatric interview (mini, sheehan et al, 1998).
boolean
C1269683 (UMLS CUI [1])
Employed | Unemployment short-term
Item
currently employed (or off work for 2 weeks or less, and expecting to return to work at the start of study).
boolean
C0557351 (UMLS CUI [1])
C0041674 (UMLS CUI [2,1])
C0443303 (UMLS CUI [2,2])
Montgomery-Asberg Depression Rating Scale Questionnaire | Moderately severe depression | Severe depression
Item
a score of 18 or greater on the self-rated version of the madrs, indicating at least moderately severe depression.
boolean
C4054475 (UMLS CUI [1])
C4304583 (UMLS CUI [2])
C0588008 (UMLS CUI [3])
Informed Consent
Item
competency to give informed consent.
boolean
C0021430 (UMLS CUI [1])
Disability short-term | Exception Circumstances Inclusion criteria | Disability Long-term
Item
patients on short-term (except for circumstances under inclusion criteria) or long-term disability.
boolean
C0231170 (UMLS CUI [1,1])
C0443303 (UMLS CUI [1,2])
C1705847 (UMLS CUI [2,1])
C0680082 (UMLS CUI [2,2])
C1512693 (UMLS CUI [2,3])
C0231170 (UMLS CUI [3,1])
C0443252 (UMLS CUI [3,2])
Pregnancy | Breast Feeding | Childbearing Potential Sexually active Contraceptive methods Absent
Item
pregnant women, lactating women and sexually active women of childbearing potential who are not using medically accepted means of contraception.
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
C3831118 (UMLS CUI [3,1])
C0241028 (UMLS CUI [3,2])
C0700589 (UMLS CUI [3,3])
C0332197 (UMLS CUI [3,4])
At risk for suicide Serious
Item
serious suicidal risks as judged by the study doctor.
boolean
C0563664 (UMLS CUI [1,1])
C0205404 (UMLS CUI [1,2])
Organic mental disorders | Substance Use Disorders | Substance Dependence | Schizophrenia | Paranoia | Delusional disorder | Psychotic Disorders | Panic Disorder | Generalized Anxiety Disorder | Obsessive-Compulsive Disorder | Post-Traumatic Stress Disorder | Bipolar Disorder | Bulimia Nervosa | Anorexia Nervosa
Item
the following dsm-iv diagnoses (to ensure a homogenous diagnostic group): organic mental disorders; substance abuse/dependence, including alcohol, active within the last year; schizophrenia, paranoid or delusional disorders; other psychotic disorders; panic disorder; generalized anxiety disorder; obsessive-compulsive disorder, or post traumatic stress disorder, if a primary diagnosis; bipolar disorder;bulimia nervosa; anorexia nervosa.
boolean
C0029227 (UMLS CUI [1])
C0038586 (UMLS CUI [2])
C0038580 (UMLS CUI [3])
C0036341 (UMLS CUI [4])
C1456784 (UMLS CUI [5])
C0011251 (UMLS CUI [6])
C0033975 (UMLS CUI [7])
C0030319 (UMLS CUI [8])
C0270549 (UMLS CUI [9])
C0028768 (UMLS CUI [10])
C0038436 (UMLS CUI [11])
C0005586 (UMLS CUI [12])
C2267227 (UMLS CUI [13])
C0003125 (UMLS CUI [14])
Illness Serious Unstable | Heart Diseases | Liver diseases | Kidney Diseases | Respiration Disorders | Endocrine System Diseases | Nervous system disorder | Hematological Disease
Item
serious illness including cardiac, hepatic, renal, respiratory, endocrinologic, neurologic and hematologic disease that is not stabilized.
boolean
C0221423 (UMLS CUI [1,1])
C0205404 (UMLS CUI [1,2])
C0443343 (UMLS CUI [1,3])
C0018799 (UMLS CUI [2])
C0023895 (UMLS CUI [3])
C0022658 (UMLS CUI [4])
C0035204 (UMLS CUI [5])
C0014130 (UMLS CUI [6])
C0027765 (UMLS CUI [7])
C0018939 (UMLS CUI [8])
Psychotropic Drugs Regular | Psychotropic Drugs
Item
regular or current use of other psychotropic drugs.
boolean
C0033978 (UMLS CUI [1,1])
C0205272 (UMLS CUI [1,2])
C0033978 (UMLS CUI [2])
Monoamine Oxidase Inhibitors | Fluoxetine | Antidepressive Agents | Washout
Item
use of monoamine oxidase inhibitors within 14 days of visit 1, fluoxetine within 5 weeks of visit 1, and other antidepressants within 7 days of visit 1 (to ensure adequate drug washouts prior to starting escitalopram).
boolean
C0026457 (UMLS CUI [1])
C0016365 (UMLS CUI [2])
C0003289 (UMLS CUI [3])
C1710661 (UMLS CUI [4])
Escitalopram
Item
previous use of escitalopram.
boolean
C1099456 (UMLS CUI [1])
Therapy Resistant Depressive episode | Antidepressive Agents Quantity failed
Item
treatment resistance in the current episode, as defined by failure (lack of clinically significant response) of two or more antidepressants given at therapeutic doses for at least 6 weeks.
boolean
C0087111 (UMLS CUI [1,1])
C0332325 (UMLS CUI [1,2])
C0349217 (UMLS CUI [1,3])
C0003289 (UMLS CUI [2,1])
C1265611 (UMLS CUI [2,2])
C0231175 (UMLS CUI [2,3])
Psychotherapy | Cognitive Therapy | Interpersonal psychotherapy
Item
patients who start formal psychotherapy (e.g. cognitive-behavioural or interpersonal psychotherapy) within 3 months of visit 1, or who plan to initiate such psychotherapy during this study.
boolean
C0033968 (UMLS CUI [1])
C0009244 (UMLS CUI [2])
C0871787 (UMLS CUI [3])
Therapeutic procedure Depressive disorder
Item
patients involved in any other form of treatment for depression.
boolean
C0087111 (UMLS CUI [1,1])
C0011581 (UMLS CUI [1,2])