Diffuse Large B-Cell Lymphoma | Lymphoma transformation | Follicular Lymphoma Ann Arbor lymphoma staging system
Item
have a histologic diagnosis of dlbcl, including transformed histology and follicular grade 3 disease.
boolean
C0079744 (UMLS CUI [1])
C1536010 (UMLS CUI [2])
C0024301 (UMLS CUI [3,1])
C0432516 (UMLS CUI [3,2])
Disease Site Quantity Biopsy | Measurable Disease 2-Dimensional | Disease Axis Size Radiographic imaging | FDG-PET Positive
Item
must have at least one site of biopsy-proven disease demonstrating both of the following: bidimensional measurable disease with the longest axis >= 1.5cm by radiographic imaging or positive fdg-pet scan at baseline.
boolean
C0012634 (UMLS CUI [1,1])
C1515974 (UMLS CUI [1,2])
C1265611 (UMLS CUI [1,3])
C0005558 (UMLS CUI [1,4])
C1513041 (UMLS CUI [2,1])
C1705052 (UMLS CUI [2,2])
C0012634 (UMLS CUI [3,1])
C1522496 (UMLS CUI [3,2])
C0456389 (UMLS CUI [3,3])
C0457276 (UMLS CUI [3,4])
C3641247 (UMLS CUI [4,1])
C1514241 (UMLS CUI [4,2])
Diffuse Large B-Cell Lymphoma | Recurrent disease Post Salvage Therapy | Refractory Disease Post Salvage Therapy | Progressive Disease Post Salvage Therapy | Recurrent disease Post First line treatment | Refractory Disease Post First line treatment | Progressive Disease Post First line treatment | Medically unfit Therapy Aggressive
Item
patients with dlbcl and who have either relapsed, refractory, or progressive disease following salvage therapy, or relapsed, refractory, or progressive disease following initial therapy and be medically unfit to receive aggressive therapy.
boolean
C0079744 (UMLS CUI [1])
C0277556 (UMLS CUI [2,1])
C0687676 (UMLS CUI [2,2])
C0085405 (UMLS CUI [2,3])
C1514815 (UMLS CUI [3,1])
C0687676 (UMLS CUI [3,2])
C0085405 (UMLS CUI [3,3])
C1335499 (UMLS CUI [4,1])
C0687676 (UMLS CUI [4,2])
C0085405 (UMLS CUI [4,3])
C0277556 (UMLS CUI [5,1])
C0687676 (UMLS CUI [5,2])
C1708063 (UMLS CUI [5,3])
C1514815 (UMLS CUI [6,1])
C0687676 (UMLS CUI [6,2])
C1708063 (UMLS CUI [6,3])
C1335499 (UMLS CUI [7,1])
C0687676 (UMLS CUI [7,2])
C1708063 (UMLS CUI [7,3])
C3841806 (UMLS CUI [8,1])
C0087111 (UMLS CUI [8,2])
C0580822 (UMLS CUI [8,3])
Availability of Tumor sample Fresh | Availability of Tumor sample Stored
Item
either fresh or archived tumor specimen must be available.
boolean
C0470187 (UMLS CUI [1,1])
C0475358 (UMLS CUI [1,2])
C0443224 (UMLS CUI [1,3])
C0470187 (UMLS CUI [2,1])
C0475358 (UMLS CUI [2,2])
C1698986 (UMLS CUI [2,3])
Event Cerebrovascular | Angina, Unstable | Myocardial Infarction | Cardiac symptoms
Item
documented history within 6 months of registration of a cerebral vascular event, unstable angina, myocardial infarction, or cardiac symptoms.
boolean
C0441471 (UMLS CUI [1,1])
C1880018 (UMLS CUI [1,2])
C0002965 (UMLS CUI [2])
C0027051 (UMLS CUI [3])
C0741933 (UMLS CUI [4])
Allogeneic Stem Cell Transplantation
Item
patients who have received allogeneic stem cell transplant.
boolean
C2242529 (UMLS CUI [1])
Invasive cancer Primary | Exception Skin carcinoma | Exception Carcinoma in situ of uterine cervix | Exception Carcinoma in situ of female breast | Exception Prostate carcinoma Resected | Exception PSA normal
Item
patients with evidence of another invasive primary malignancy within the past three years other than non-melanoma skin cancer, cervical carcinoma in situ, in situ carcinoma of the breast, or fully resected prostate cancer with normal psa within 8 weeks of registration.
boolean
C0677898 (UMLS CUI [1,1])
C0205225 (UMLS CUI [1,2])
C1705847 (UMLS CUI [2,1])
C0699893 (UMLS CUI [2,2])
C1705847 (UMLS CUI [3,1])
C0851140 (UMLS CUI [3,2])
C1705847 (UMLS CUI [4,1])
C0686288 (UMLS CUI [4,2])
C1705847 (UMLS CUI [5,1])
C0600139 (UMLS CUI [5,2])
C1521996 (UMLS CUI [5,3])
C1705847 (UMLS CUI [6,1])
C0580554 (UMLS CUI [6,2])
Systemic viral infection | Systemic bacterial infection | Systemic mycosis | Requirement Anti-Infective Agents Intravenous
Item
patients with any active systemic viral, bacterial, or fungal infection requiring intravenous anti-infectives within 4 weeks prior to first dose of study drug.
boolean
C4285789 (UMLS CUI [1])
C4285778 (UMLS CUI [2])
C0553576 (UMLS CUI [3])
C1514873 (UMLS CUI [4,1])
C0003204 (UMLS CUI [4,2])
C1522726 (UMLS CUI [4,3])
Leptomeningeal Lymphoma | Central nervous system lymphoma
Item
patients with a history or clinical evidence of leptomeningeal or central nervous system (cns) lymphoma.
boolean
C2213017 (UMLS CUI [1])
C0742472 (UMLS CUI [2])