Age
Item
patient is 20 to 74 years old
boolean
C0001779 (UMLS CUI [1])
Lymphoma, Follicular | Indolent Non-Hodgkin Lymphoma B-cell | Mantle cell lymphoma | Recurrent Follicular Lymphoma | Refractory Follicular Lymphoma
Item
patient has an histopathologically confirmed fl, or other indolent b-nhl or mcl (only relapsed / refractory fl can be included outside japan.)
boolean
C0024301 (UMLS CUI [1])
C1334170 (UMLS CUI [2,1])
C0004561 (UMLS CUI [2,2])
C0334634 (UMLS CUI [3])
C1335701 (UMLS CUI [4])
C1335723 (UMLS CUI [5])
Measurable lesion Quantity CT scan
Item
patient has at least one measurable lesion by ct scan which is defined by cheson's 1999 criteria
boolean
C1513041 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
C0040405 (UMLS CUI [1,3])
Chemotherapy Regimen Quantity | Partial response failed | Recurrent disease Post Complete remission | Recurrent disease Post Partial response
Item
patient has received at least 1 but up to 4 prior chemotherapeutic regimen, the most recent therapy must have failed to induce a partial response, or there must be recurrence in case of the most recent therapy has shown complete response, or there must be relapse in case of the most recent therapy has shown partial response.
boolean
C0392920 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
C1521726 (UMLS CUI [2,1])
C0231175 (UMLS CUI [2,2])
C0277556 (UMLS CUI [3,1])
C0687676 (UMLS CUI [3,2])
C0677874 (UMLS CUI [3,3])
C0277556 (UMLS CUI [4,1])
C0687676 (UMLS CUI [4,2])
C1521726 (UMLS CUI [4,3])
Organ function | Bone Marrow function
Item
patient must have adequate organ and marrow function
boolean
C0678852 (UMLS CUI [1])
C0005953 (UMLS CUI [2,1])
C0031843 (UMLS CUI [2,2])
Transplantation, Homologous | Transplantation of autologous hematopoietic stem cell
Item
patient who has undergone allogenic transplant treatment or autologous stem cell transplant within 6 months
boolean
C0040739 (UMLS CUI [1])
C1831743 (UMLS CUI [2])
Cancer Other | Central Nervous System Infiltration Lymphoma
Item
patient with other active malignancies or central neurological infiltration with lymphoma
boolean
C1707251 (UMLS CUI [1])
C3714787 (UMLS CUI [2,1])
C0332448 (UMLS CUI [2,2])
C0024299 (UMLS CUI [2,3])
Hepatic Insufficiency Severe
Item
patient with severe hepatic insufficiency
boolean
C1306571 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
Allergic Reaction Vorinostat Component
Item
patient with history of allergic reactions attributed to any component of mk0683
boolean
C1527304 (UMLS CUI [1,1])
C0672708 (UMLS CUI [1,2])
C1705248 (UMLS CUI [1,3])
HIV antibody positive | Hepatitis B antigen positive | Hepatitis C antibody positive
Item
patient who is known to be hiv antibody-, hbv antigen- or hcv antibody-positive
boolean
C0920548 (UMLS CUI [1])
C1504344 (UMLS CUI [2])
C0281863 (UMLS CUI [3])
Vorinostat | Histone deacetylase inhibitor
Item
patient who has undergone prior/concomitant treatment with mk0683 or other hdac inhibitors
boolean
C0672708 (UMLS CUI [1])
C1512474 (UMLS CUI [2])