Solid Neoplasm | Malignant lymphoid neoplasm | Lymphoma | Chronic Lymphocytic Leukemia | Refractory Standard of Care | Standard of Care Absent | Disease Progression Post Standard of Care Quantity | Aggressive Non-Hodgkin Lymphoma | Refractory Disease | Indolent Non-Hodgkin Lymphoma
Item
patients with histologically documented (by the nih pathology department) solid tumors and lymphoid malignancies (lymphoma and cll) who are refractory to standard therapy or who have no acceptable standard treatment options. patients with lymphoid malignancies will be eligible if their disease has progressed following 2 standard therapies (aggressive nhl), and if their disease is considered refractory (for indolent nhl).
boolean
C0280100 (UMLS CUI [1])
C0746336 (UMLS CUI [2])
C0024299 (UMLS CUI [3])
C0023434 (UMLS CUI [4])
C0205269 (UMLS CUI [5,1])
C2936643 (UMLS CUI [5,2])
C2936643 (UMLS CUI [6,1])
C0332197 (UMLS CUI [6,2])
C0242656 (UMLS CUI [7,1])
C0687676 (UMLS CUI [7,2])
C2936643 (UMLS CUI [7,3])
C1265611 (UMLS CUI [7,4])
C1332225 (UMLS CUI [8])
C1514815 (UMLS CUI [9])
C1334170 (UMLS CUI [10])
Measurable Disease | Evaluable Disease
Item
patients must have measurable or evaluable disease.
boolean
C1513041 (UMLS CUI [1])
C1516986 (UMLS CUI [2])
Patient recovered Toxicity CTCAE Grades | Toxicity Due to Adverse event | Toxicity Due to Prior Chemotherapy | Toxicity Due to Biological treatment | Nitrosourea | Mitomycin | UCN 01 | Study Subject Participation Status | Investigational New Drugs | Prior radiation therapy | Major surgery | Diphosphonates Malignant Neoplasms | Antiandrogen therapy Prostate carcinoma
Item
patients must have recovered to at least grade less than or equal to1 toxicity levels due to adverse events and/or toxicity of prior chemotherapy or biologic therapy. they must not have had chemotherapy or biologic therapy within 4 weeks prior to entering the study (6 weeks for nitrosoureas or mitomycin c, or ucn-01). patients must be greater than or equal to 2 weeks since any prior administration of study drug in an exploratory ind/phase zero study. patients must be greater than or equal to 1 month since any prior radiation or major surgery. however, patients receiving bisphosphonates for any cancer or undergoing androgen deprivation therapy for prostate cancer are eligible for this therapy.
boolean
C1115804 (UMLS CUI [1,1])
C0600688 (UMLS CUI [1,2])
C1516728 (UMLS CUI [1,3])
C0600688 (UMLS CUI [2,1])
C0678226 (UMLS CUI [2,2])
C0877248 (UMLS CUI [2,3])
C0600688 (UMLS CUI [3,1])
C0678226 (UMLS CUI [3,2])
C1514457 (UMLS CUI [3,3])
C0600688 (UMLS CUI [4,1])
C0678226 (UMLS CUI [4,2])
C1531518 (UMLS CUI [4,3])
C0028210 (UMLS CUI [5])
C0002475 (UMLS CUI [6])
C0950721 (UMLS CUI [7])
C2348568 (UMLS CUI [8])
C0013230 (UMLS CUI [9])
C0279134 (UMLS CUI [10])
C0679637 (UMLS CUI [11])
C0012544 (UMLS CUI [12,1])
C0006826 (UMLS CUI [12,2])
C0279492 (UMLS CUI [13,1])
C0600139 (UMLS CUI [13,2])
Age
Item
age greater than or equal to 18 years
boolean
C0001779 (UMLS CUI [1])
ECOG performance status | Karnofsky Performance Status
Item
the eastern cooperative oncology group (ecog) performance status less than or equal to 2 (karnofsky greater than or equal to 60%).
boolean
C1520224 (UMLS CUI [1])
C0206065 (UMLS CUI [2])
Life Expectancy
Item
life expectancy greater than 3 months
boolean
C0023671 (UMLS CUI [1])
Organ function | Bone Marrow function
Item
patients must have normal or adequate organ and marrow function as defined below:
boolean
C0678852 (UMLS CUI [1])
C0005953 (UMLS CUI [2,1])
C0031843 (UMLS CUI [2,2])
Absolute neutrophil count
Item
absolute neutrophil count greater than or equal to 1,500/milliliter
boolean
C0948762 (UMLS CUI [1])
Platelet Count measurement
Item
platelets greater than or equal to 100,000/milliliter
boolean
C0032181 (UMLS CUI [1])
Serum total bilirubin measurement
Item
total bilirubin* within less than or equal to 1.5 times upper limit of normal
boolean
C1278039 (UMLS CUI [1])
Aspartate aminotransferase measurement | Alanine aminotransferase measurement
Item
ast (sgot)/alt (sgpt) less than or equal to 2.5 times institutional upper limit of normal
boolean
C0201899 (UMLS CUI [1])
C0201836 (UMLS CUI [2])
Creatinine measurement, serum
Item
creatinine less than 1.5 times upper limit of normal
boolean
C0201976 (UMLS CUI [1])
Creatinine clearance measurement | Serum creatinine raised
Item
creatinine clearance greater than or equal to 60 ml/min (measured) for patients with creatinine levels greater than or equal to 1.5 times upper limit of normal.
boolean
C0373595 (UMLS CUI [1])
C0700225 (UMLS CUI [2])
Gilbert Disease | Serum total bilirubin measurement
Item
*we will allow patients with gilbert's syndrome with total bilirubin up to 2.5 mg/dl
boolean
C0017551 (UMLS CUI [1])
C1278039 (UMLS CUI [2])
Childbearing Potential Contraceptive methods | Gender Contraceptive methods | Hormonal contraception | Contraception, Barrier | Sexual Abstinence | Childbearing Potential Pregnancy test negative
Item
the effects of snx-5422 on the developing human fetus are unknown. for this reason, women of childbearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control or abstinence) prior to study entry, for the duration of study participation, and for 2 months after discontinuation from the study. women of childbearing potential must have a negative pregnancy test in order to be eligible. should a woman become pregnant or suspect she is pregnant while participating in this study, she should inform her treating physician immediately. because there is an unknown but potential risk for adverse events in nursing infants secondary to treatment of the mother with snx-5422, breastfeeding should be discontinued if the mother is treated with snx-5422.
boolean
C3831118 (UMLS CUI [1,1])
C0700589 (UMLS CUI [1,2])
C0079399 (UMLS CUI [2,1])
C0700589 (UMLS CUI [2,2])
C2985296 (UMLS CUI [3])
C0004764 (UMLS CUI [4])
C0036899 (UMLS CUI [5])
C3831118 (UMLS CUI [6,1])
C0427780 (UMLS CUI [6,2])
Informed Consent
Item
ability to understand and the willingness to sign a written informed consent document.
boolean
C0021430 (UMLS CUI [1])
Investigational New Drugs | Metastatic malignant neoplasm to brain Symptomatic | Prognosis bad | Development Frequently Progressive neurologic dysfunction | Interference Evaluation Neurological event | Interference Evaluation Adverse event
Item
patients receiving any other investigational agents. patients with symptomatic brain metastases should be excluded from this clinical trial because of their poor prognosis and because they often develop progressive neurologic dysfunction that would confound the evaluation of neurologic and other adverse events. however, patients who have had treatment for their brain metastases and whose brain metastatic disease status has remained stable for at least 3 months without steroids may be enrolled at the discretion of the principal investigator.
boolean
C0013230 (UMLS CUI [1])
C0220650 (UMLS CUI [2,1])
C0231220 (UMLS CUI [2,2])
C0278252 (UMLS CUI [3])
C0243107 (UMLS CUI [4,1])
C0332183 (UMLS CUI [4,2])
C4013375 (UMLS CUI [4,3])
C0521102 (UMLS CUI [5,1])
C1261322 (UMLS CUI [5,2])
C1320718 (UMLS CUI [5,3])
C0521102 (UMLS CUI [6,1])
C1261322 (UMLS CUI [6,2])
C0877248 (UMLS CUI [6,3])
Illness Uncontrolled | Symptomatic congestive heart failure American Heart Association Class | Symptomatic congestive heart failure Uncontrolled American Heart Association Class | Uncontrolled hypertension | Angina, Unstable | Cardiac Arrhythmia | Mental disorders Protocol Compliance Limited | Social situation Protocol Compliance Limited
Item
uncontrolled medical illness including, but not limited to, ongoing or uncontrolled, symptomatic congestive heart failure (aha class ii or worse), uncontrolled hypertension, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.
boolean
C0221423 (UMLS CUI [1,1])
C0205318 (UMLS CUI [1,2])
C0742758 (UMLS CUI [2,1])
C0002458 (UMLS CUI [2,2])
C0456387 (UMLS CUI [2,3])
C0742758 (UMLS CUI [3,1])
C0205318 (UMLS CUI [3,2])
C0002458 (UMLS CUI [3,3])
C0456387 (UMLS CUI [3,4])
C1868885 (UMLS CUI [4])
C0002965 (UMLS CUI [5])
C0003811 (UMLS CUI [6])
C0004936 (UMLS CUI [7,1])
C0525058 (UMLS CUI [7,2])
C0439801 (UMLS CUI [7,3])
C0748872 (UMLS CUI [8,1])
C0525058 (UMLS CUI [8,2])
C0439801 (UMLS CUI [8,3])
Antiretroviral therapy HIV Seropositivity | Pharmacokinetic interaction SNX-5422 | HIV Seropositivity | Risk Due to SNX-5422
Item
hiv-positive patients receiving combination antiretroviral therapy are excluded from the study because of possible pk interactions with snx-5422. hiv positive patients not receiving antiretroviral therapy are excluded due to the possibility that snx-5422 may worsen their condition and the likelihood that the underlying condition may obscure the attribution of adverse events with respect to snx-5422.
boolean
C1963724 (UMLS CUI [1,1])
C0019699 (UMLS CUI [1,2])
C1868980 (UMLS CUI [2,1])
C3253587 (UMLS CUI [2,2])
C0019699 (UMLS CUI [3])
C0035647 (UMLS CUI [4,1])
C0678226 (UMLS CUI [4,2])
C3253587 (UMLS CUI [4,3])
Chronic diarrhea
Item
chronic diarrhea.
boolean
C0401151 (UMLS CUI [1])
Gastrointestinal Diseases Affecting Drug absorption | Postoperative state | Gastric Bypass
Item
gastrointestinal diseases that could affect drug absorption, including postsurgical states such as gastric bypass.
boolean
C0017178 (UMLS CUI [1,1])
C0392760 (UMLS CUI [1,2])
C0678745 (UMLS CUI [1,3])
C0231287 (UMLS CUI [2])
C0017125 (UMLS CUI [3])
Gastrointestinal Diseases Changing Assessment Safety | Irritable Bowel Syndrome | Ulcerative Colitis | Crohn Disease | Hemorrhagic Proctocolitis
Item
gastrointestinal diseases that could alter the assessment of safety, including irritable bowel syndrome, ulcerative colitis, crohn's disease, or hemorrhagic coloproctitis.
boolean
C0017178 (UMLS CUI [1,1])
C0392747 (UMLS CUI [1,2])
C1516048 (UMLS CUI [1,3])
C0036043 (UMLS CUI [1,4])
C0022104 (UMLS CUI [2])
C0009324 (UMLS CUI [3])
C0010346 (UMLS CUI [4])
C1257847 (UMLS CUI [5])