Prior Therapy Mantle cell lymphoma | Prior Therapy Diffuse Large B-Cell Lymphoma | Mediastinal (Thymic) Large B-Cell Lymphoma | Diffuse Large B-Cell Lymphoma Transformed | Diffuse Large B-Cell Lymphoma Follicular Ann Arbor lymphoma staging system | Intravascular large b-cell lymphoma
Item
previously treated mantle cell lymphoma or diffuse large b-cell lymphoma (to include mediastinal (thymic) large b-cell lymphoma; transformed large b-cell lymphoma; follicular grade iiib large b-cell lymphoma; intravascular large b-cell lymphoma).
boolean
C1514463 (UMLS CUI [1,1])
C0334634 (UMLS CUI [1,2])
C1514463 (UMLS CUI [2,1])
C0079744 (UMLS CUI [2,2])
C1292754 (UMLS CUI [3])
C0079744 (UMLS CUI [4,1])
C0457344 (UMLS CUI [4,2])
C0079744 (UMLS CUI [5,1])
C0439682 (UMLS CUI [5,2])
C0432516 (UMLS CUI [5,3])
C0334660 (UMLS CUI [6])
Diagnosis Pathological
Item
confirmed pathological diagnosis at the national cancer institute, national institutes of health (nih).
boolean
C0011900 (UMLS CUI [1,1])
C0205469 (UMLS CUI [1,2])
Measurable Disease 2-Dimensional Recurrent | Leukemia Measurable
Item
recurrent measurable disease (measurable disease in 2 dimensions or leukemic disease which can be quantified and followed).
boolean
C1513041 (UMLS CUI [1,1])
C1705052 (UMLS CUI [1,2])
C2945760 (UMLS CUI [1,3])
C0023418 (UMLS CUI [2,1])
C1513040 (UMLS CUI [2,2])
Prior anthracycline therapy Diffuse Large B-Cell Lymphoma
Item
prior anthracycline-based treatment for patients with diffuse large b-cell lymphoma (dlbcl).
boolean
C0278941 (UMLS CUI [1,1])
C0079744 (UMLS CUI [1,2])
Age
Item
age greater than 18 years.
boolean
C0001779 (UMLS CUI [1])
ECOG performance status
Item
eastern cooperative oncology group (ecog) performance 2 or better.
boolean
C1520224 (UMLS CUI [1])
Organ function | Absolute neutrophil count | Platelet Count measurement | Creatinine measurement, serum | Creatinine clearance measurement | Alanine aminotransferase measurement | Serum total bilirubin measurement | Exception Gilbert Disease | Unconjugated bilirubin
Item
major organ function: absolute neutrophil count (anc) greater than 1000/mcl, platelet greater than 50,000/mcl, creatinine less than 1.5 mg/dl or creatinine clearance greater than 60 ml/min; serum glutamic pyruvic transaminase (sgpt) less than 5 x upper limit of normal; bilirubin less than 2 mg/dl (total) except less than 5 mg/dl in patients with gilbert's syndrome as defined by greater than 80% unconjugated. anc and platelet requirements must be met independent of transfusion.
boolean
C0678852 (UMLS CUI [1])
C0948762 (UMLS CUI [2])
C0032181 (UMLS CUI [3])
C0201976 (UMLS CUI [4])
C0373595 (UMLS CUI [5])
C0201836 (UMLS CUI [6])
C1278039 (UMLS CUI [7])
C1705847 (UMLS CUI [8,1])
C0017551 (UMLS CUI [8,2])
C0857544 (UMLS CUI [9])
Informed Consent | Contraceptive methods Willing
Item
informed consent and willingness to use contraception by both men and women.
boolean
C0021430 (UMLS CUI [1])
C0700589 (UMLS CUI [2,1])
C0600109 (UMLS CUI [2,2])
Contraceptive methods Willing | Contraception, Barrier | Sexual Abstinence
Item
both male and female patients must be willing to use adequate contraception (to include effective barrier methods of contraception) or to completely abstain from heterosexual intercourse while on protocol treatment.
boolean
C0700589 (UMLS CUI [1,1])
C0600109 (UMLS CUI [1,2])
C0004764 (UMLS CUI [2])
C0036899 (UMLS CUI [3])
Pregnancy | Breast Feeding | Potential Unknown Teratogeniic effect | Potential Unknown Abortifacient Effect
Item
pregnant or nursing because of an unknown potential for teratogenic or abortifacient effects.
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
C3245505 (UMLS CUI [3,1])
C0439673 (UMLS CUI [3,2])
C0232910 (UMLS CUI [3,3])
C3245505 (UMLS CUI [4,1])
C0439673 (UMLS CUI [4,2])
C3179338 (UMLS CUI [4,3])
Serology negative HIV | Exclusion Antiretroviral therapy HIV Seropositivity | Drug Interaction alvocidib Possible
Item
human immunodeficiency virus (hiv) serology negative. hiv positive patients receiving combination anti-retroviral therapy are excluded from the study because of possible pharmacokinetic interactions with flavopiridol. additionally, the biology of hiv associated dlbcl's is often quite different from hiv negative disease due to involvement of epstein barr virus (ebv).
boolean
C0919674 (UMLS CUI [1,1])
C0019682 (UMLS CUI [1,2])
C2828389 (UMLS CUI [2,1])
C1963724 (UMLS CUI [2,2])
C0019699 (UMLS CUI [2,3])
C0687133 (UMLS CUI [3,1])
C0281603 (UMLS CUI [3,2])
C0332149 (UMLS CUI [3,3])
Hepatitis B surface antigen negative
Item
hepatitis b surface antigen negative.
boolean
C0919711 (UMLS CUI [1])
Central nervous system lymphoma | Prognosis bad | Development Progressive Neurologic dysfunction Frequently | Progressive Neurologic dysfunction Interferes with Evaluation Neurological event | Progressive Neurologic dysfunction Interferes with Evaluation Adverse event
Item
active central nervous system (cns) lymphoma. these patients have a poor prognosis and because they frequently develop progressive neurological dysfunction that would confound the evaluation of neurological and other adverse events.
boolean
C0742472 (UMLS CUI [1])
C0278252 (UMLS CUI [2])
C0243107 (UMLS CUI [3,1])
C4013375 (UMLS CUI [3,2])
C0332183 (UMLS CUI [3,3])
C4013375 (UMLS CUI [4,1])
C0521102 (UMLS CUI [4,2])
C1261322 (UMLS CUI [4,3])
C1320718 (UMLS CUI [4,4])
C4013375 (UMLS CUI [5,1])
C0521102 (UMLS CUI [5,2])
C1261322 (UMLS CUI [5,3])
C0877248 (UMLS CUI [5,4])
Inflammatory Bowel Disease | Exception Disease remission
Item
history of inflammatory bowel disease unless this has been inactive for a period of 2 or more years.
boolean
C0021390 (UMLS CUI [1])
C1705847 (UMLS CUI [2,1])
C0544452 (UMLS CUI [2,2])
Prior Therapy Toxicity | Recovery Toxicity CTCAE Grades
Item
recovery from toxicity of prior therapy to a grade 1 or less.
boolean
C1514463 (UMLS CUI [1,1])
C0600688 (UMLS CUI [1,2])
C2004454 (UMLS CUI [2,1])
C0600688 (UMLS CUI [2,2])
C1516728 (UMLS CUI [2,3])
Cytotoxic therapy Systemic | Investigational Therapies Systemic
Item
systemic cytotoxic or experimental treatments within 4 weeks of treatment.
boolean
C0677881 (UMLS CUI [1,1])
C0205373 (UMLS CUI [1,2])
C0949266 (UMLS CUI [2,1])
C0205373 (UMLS CUI [2,2])
White Blood Cell Count procedure
Item
white blood cell (wbc) greater than 100,000 cells/mcl.
boolean
C0023508 (UMLS CUI [1])