Acute lymphocytic leukemia Type Any
Item
diagnosis of all (any type included), in patients who:
boolean
C0023449 (UMLS CUI [1,1])
C0332307 (UMLS CUI [1,2])
C1552551 (UMLS CUI [1,3])
Recurrent disease Post Chemotherapy
Item
have relapsed after conventional chemotherapy* or,
boolean
C0277556 (UMLS CUI [1,1])
C0687676 (UMLS CUI [1,2])
C0392920 (UMLS CUI [1,3])
Patients refractory | Chemotherapy cycle Quantity
Item
are refractory to at least 1 cycle of chemotherapy*
boolean
C0030705 (UMLS CUI [1,1])
C0205269 (UMLS CUI [1,2])
C1302181 (UMLS CUI [2,1])
C1265611 (UMLS CUI [2,2])
ECOG performance status
Item
ecog performance score of 0-3
boolean
C1520224 (UMLS CUI [1])
Liver function | Renal function | Transaminase Assay | Serum total bilirubin measurement | Creatinine measurement, serum
Item
adequate hepatic and renal function, as defined by serum transaminases <2.5x uln, bilirubin <1.5xuln, and creatinine <1.5x uln.
boolean
C0232741 (UMLS CUI [1])
C0232804 (UMLS CUI [2])
C0919834 (UMLS CUI [3])
C1278039 (UMLS CUI [4])
C0201976 (UMLS CUI [5])
Age
Item
age 18 years or greater.
boolean
C0001779 (UMLS CUI [1])
Informed Consent
Item
documentation of written informed consent to participate in the trial.
boolean
C0021430 (UMLS CUI [1])
Protocol Compliance
Item
willingness and ability to comply with scheduled visits, treatment plan, laboratory tests and other study procedures.
boolean
C0525058 (UMLS CUI [1])
Prior Chemotherapy | Cancer treatment Investigational | Toxicity Patient recovered
Item
at least 3 weeks from prior chemotherapy or other investigational anticancer therapy with full recovery from prior toxicities.
boolean
C1514457 (UMLS CUI [1])
C0920425 (UMLS CUI [2,1])
C1517586 (UMLS CUI [2,2])
C0600688 (UMLS CUI [3,1])
C1115804 (UMLS CUI [3,2])
Contraceptive methods Accepting | Exception Infertility Documented
Item
either men or women, accepting to practice effective contraception during the entire study period unless documentation of infertility exists.
boolean
C0700589 (UMLS CUI [1,1])
C1272684 (UMLS CUI [1,2])
C1705847 (UMLS CUI [2,1])
C0021359 (UMLS CUI [2,2])
C1301725 (UMLS CUI [2,3])
Investigational New Drugs
Item
treatment with any investigational agent within 3 weeks prior to study therapy.
boolean
C0013230 (UMLS CUI [1])
Major surgery | Operative Surgical Procedures Recovery Lacking
Item
major surgeries within 4 weeks from study start or not fully recovered from any previous surgical procedure.
boolean
C0679637 (UMLS CUI [1])
C0543467 (UMLS CUI [2,1])
C2004454 (UMLS CUI [2,2])
C0332268 (UMLS CUI [2,3])
Medical condition Protocol Compliance Limited | Mental condition Protocol Compliance Limited | Medical condition At risk Study Subject Participation Status | Mental condition At risk Study Subject Participation Status | Medical condition At risk Investigational New Drugs | Mental condition At risk Investigational New Drugs
Item
presence of any medical or psychiatric condition which may limit full compliance with the study or increase the risk associated with study participation or study drug administration, including but not limited to:
boolean
C3843040 (UMLS CUI [1,1])
C0525058 (UMLS CUI [1,2])
C0439801 (UMLS CUI [1,3])
C3840291 (UMLS CUI [2,1])
C0525058 (UMLS CUI [2,2])
C0439801 (UMLS CUI [2,3])
C3843040 (UMLS CUI [3,1])
C1444641 (UMLS CUI [3,2])
C2348568 (UMLS CUI [3,3])
C3840291 (UMLS CUI [4,1])
C1444641 (UMLS CUI [4,2])
C2348568 (UMLS CUI [4,3])
C3843040 (UMLS CUI [5,1])
C1444641 (UMLS CUI [5,2])
C0013230 (UMLS CUI [5,3])
C3840291 (UMLS CUI [6,1])
C1444641 (UMLS CUI [6,2])
C0013230 (UMLS CUI [6,3])
Central nervous system leukaemia
Item
presence of central nervous system (cns) leukemia.
boolean
C1332884 (UMLS CUI [1])
Bacterial Infection Uncontrolled
Item
active uncontrolled bacterial infection.
boolean
C0004623 (UMLS CUI [1,1])
C0205318 (UMLS CUI [1,2])
HIV Infection
Item
known human immunodeficiency virus (hiv) infection.
boolean
C0019693 (UMLS CUI [1])
Cardiovascular Diseases | Cardiac Arrhythmia Uncontrolled | Angina, Unstable | Thromboembolism Major | Myocardial Infarction | Cerebrovascular accident | Transient Ischemic Attack | Pulmonary Embolism | Deep Vein Thrombosis Independent of Catheter
Item
significant cardiovascular disease (i.e., uncontrolled arrhythmias, unstable angina), or a major thromboembolic event (myocardial infarction, stroke, transient ischemic attack, pulmonary embolism, or non-catheter-related deep-vein thrombosis) in the last 6 months.
boolean
C0007222 (UMLS CUI [1])
C0003811 (UMLS CUI [2,1])
C0205318 (UMLS CUI [2,2])
C0002965 (UMLS CUI [3])
C0040038 (UMLS CUI [4,1])
C0205164 (UMLS CUI [4,2])
C0027051 (UMLS CUI [5])
C0038454 (UMLS CUI [6])
C0007787 (UMLS CUI [7])
C0034065 (UMLS CUI [8])
C0149871 (UMLS CUI [9,1])
C0332291 (UMLS CUI [9,2])
C0085590 (UMLS CUI [9,3])
Pregnancy | Breast Feeding
Item
pregnancy or breast-feeding.
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Malabsorption Syndrome
Item
malabsorption syndromes
boolean
C0024523 (UMLS CUI [1])