Acute lymphoid leukemia in remission | Acute lymphoblastic leukemia, in relapse | Acute biphenotypic leukemia in remission | Acute biphenotypic leukemia in relapse
Item
1. patients with biopsy-proven acute lymphoblastic leukemia, acute lymphoblastic lymphoma, or acute biphenotypic leukemia in remission or relapse.
boolean
C0153876 (UMLS CUI [1])
C2854088 (UMLS CUI [2])
C4067208 (UMLS CUI [3])
C4067209 (UMLS CUI [4])
Renal function | Estimation of creatinine clearance by Cockcroft-Gault formula
Item
2. adequate renal function, as defined by estimated serum creatinine clearance >60 ml/min.
boolean
C0232804 (UMLS CUI [1])
C2711451 (UMLS CUI [2])
Serum total bilirubin measurement | Exception Gilbert Disease | Alanine aminotransferase measurement | Alkaline phosphatase measurement
Item
3. bilirubin equal or less than 1.5 (unless gilbert's syndrome), sgpt <3 x upper limit of normal and alkaline phosphatase <2 x upper limit of normal.
boolean
C1278039 (UMLS CUI [1])
C1705847 (UMLS CUI [2,1])
C0017551 (UMLS CUI [2,2])
C0201836 (UMLS CUI [3])
C0201850 (UMLS CUI [4])
Pulmonary function | FEV1 | FVC | Hemoglobin Corrected DLCO | Children Pulmonary function test Unable | Oxygen saturation measurement on room air
Item
4. adequate pulmonary function with fev1, fvc and dlco at least 45% of expected corrected for hemoglobin. children unable to perform pulmonary functions must have an oxygen saturation greater than 92% at room air.
boolean
C0231921 (UMLS CUI [1])
C0849974 (UMLS CUI [2])
C3714541 (UMLS CUI [3])
C4054790 (UMLS CUI [4])
C0008059 (UMLS CUI [5,1])
C0024119 (UMLS CUI [5,2])
C1299582 (UMLS CUI [5,3])
C0523807 (UMLS CUI [6,1])
C2709070 (UMLS CUI [6,2])
Cardiac function | Left ventricular ejection fraction | Therapeutic procedure | Cardiac Arrhythmia Uncontrolled Absent | Heart Disease Symptomatic Absent
Item
5. adequate cardiac function with left ventricular ejection fraction at least 45% on appropriate medical therapy. no uncontrolled arrhythmias or symptomatic cardiac disease.
boolean
C0232164 (UMLS CUI [1])
C0428772 (UMLS CUI [2])
C0087111 (UMLS CUI [3])
C0003811 (UMLS CUI [4,1])
C0205318 (UMLS CUI [4,2])
C0332197 (UMLS CUI [4,3])
C0018799 (UMLS CUI [5,1])
C0231220 (UMLS CUI [5,2])
C0332197 (UMLS CUI [5,3])
Zubrod Performance Status | Lansky Play-Performance Status | Karnofsky Performance Status
Item
6. zubrod performance status <2 or lansky/karnofsky ps equal or greater to 70%.
boolean
C3714786 (UMLS CUI [1])
C1522275 (UMLS CUI [2])
C0206065 (UMLS CUI [3])
Donor related HLA Identical | Unrelated Donor HLA Match | High resolution Typing
Item
7. patients must have a related, genotypically hla identical donor, or they must have a unrelated donor who is 8/8 hla match by high resolution typing.
boolean
C0013018 (UMLS CUI [1,1])
C0080103 (UMLS CUI [1,2])
C0019721 (UMLS CUI [1,3])
C0205280 (UMLS CUI [1,4])
C3179133 (UMLS CUI [2,1])
C0019721 (UMLS CUI [2,2])
C1708943 (UMLS CUI [2,3])
C1719039 (UMLS CUI [3,1])
C0005844 (UMLS CUI [3,2])
Informed Consent | Informed Consent Patient Representative | Informed Consent Parent | Informed Consent Guardian | Assent Minor (person) | Age
Item
8. patient or patient's legal representative, parent(s) or guardian should provide written informed consent. assent of a minor if participant's age is at least seven and less than eighteen years.
boolean
C0021430 (UMLS CUI [1])
C0021430 (UMLS CUI [2,1])
C0030701 (UMLS CUI [2,2])
C0021430 (UMLS CUI [3,1])
C0030551 (UMLS CUI [3,2])
C0021430 (UMLS CUI [4,1])
C1274041 (UMLS CUI [4,2])
C1879749 (UMLS CUI [5,1])
C0026193 (UMLS CUI [5,2])
C0001779 (UMLS CUI [6])
Childbearing Potential Serum Beta-HCG Test Negative | Postmenopausal state Absent | Female Sterilization Absent
Item
9. negative beta hcg test in a woman with child bearing potential defined as not post-menopausal for 12 months and no previous surgical sterilization.
boolean
C3831118 (UMLS CUI [1,1])
C1255526 (UMLS CUI [1,2])
C1513916 (UMLS CUI [1,3])
C0232970 (UMLS CUI [2,1])
C0332197 (UMLS CUI [2,2])
C0015787 (UMLS CUI [3,1])
C0332197 (UMLS CUI [3,2])
Toxicity CTCAE Grades | Etiology Prior Therapy | Resolution Lacking
Item
1. patients with unresolved grade >2 non-hematologic toxicity from previous therapy. patients with grade 2 toxicity will be eligible at the discretion of the pi.
boolean
C0600688 (UMLS CUI [1,1])
C1516728 (UMLS CUI [1,2])
C0015127 (UMLS CUI [2,1])
C1514463 (UMLS CUI [2,2])
C1514893 (UMLS CUI [3,1])
C0332268 (UMLS CUI [3,2])
CNS disorder
Item
2. patients with active cns disease.
boolean
C0007682 (UMLS CUI [1])
Hepatitis | Hepatitis, Chronic | Liver Cirrhosis | Liver Cirrhosis chronic
Item
3. evidence of acute or chronic active hepatitis or cirrhosis.
boolean
C0019158 (UMLS CUI [1])
C0019189 (UMLS CUI [2])
C0023890 (UMLS CUI [3])
C0023890 (UMLS CUI [4,1])
C0205191 (UMLS CUI [4,2])
Communicable Disease Uncontrolled | HIV Infection | HTLV-I Infection | Hepatitis B Viremia | Hepatitis C Viremia
Item
4. uncontrolled infection, including hiv, htlv-1, hepatitis b or hepatitis c viremia.
boolean
C0009450 (UMLS CUI [1,1])
C0205318 (UMLS CUI [1,2])
C0019693 (UMLS CUI [2])
C0020097 (UMLS CUI [3])
C0019163 (UMLS CUI [4,1])
C0042749 (UMLS CUI [4,2])
C0019196 (UMLS CUI [5,1])
C0042749 (UMLS CUI [5,2])
Age
Item
5. patients greater than 65 years-old.
boolean
C0001779 (UMLS CUI [1])
Transplantation of autologous hematopoietic stem cell | Allogeneic Hematopoietic Stem Cell Transplantation
Item
6. prior autologous or allogeneic hematopoietic stem cell transplant.
boolean
C1831743 (UMLS CUI [1])
C1705576 (UMLS CUI [2])