Philadelphia chromosome positive CML | Age
Item
patients with philadelphia (ph) chromosome positive cml < age 65 and older than 21 years.
boolean
C0279543 (UMLS CUI [1])
C0001779 (UMLS CUI [2])
Philadelphia chromosome positive CML Chronic phase First Late | Philadelphia chromosome positive CML Chronic phase Early | Cytogenetic Complete Response failed | Imatinib | Philadelphia chromosome positive CML Except Chronic phase First | Philadelphia chromosome positive CML Accelerated phase | Philadelphia chromosome positive CML Blastic Phase | Disease Response | Bone Marrow Percentage | Blast cells present | Philadelphia chromosome positive CML Chronic phase | Imatinib Resistance | Loss Molecular Complete Response | Other Coding | Loss Cytogenetic Complete Response
Item
ph positive cml that is either in: 1. late 1st chronic phase (> 2 years from diagnosis) 2. early chronic phase who did not achieve complete cytogenetic remission after one year on imatinib 3. beyond first chronic phase 4. accelerated phase 5. blastic phase that has responded to therapy (characterized by the presence of < 10% bone marrow and/or circulating blasts at consent signing) 6. chronic phase, developing imatinib resistance (loss of molecular remission defined as at least a 1 log increase in the bcr-abl/abl ratio, in 2 time points at least 1 month apart, or loss of cytogenetic remission)
boolean
C0279543 (UMLS CUI [1,1])
C0457343 (UMLS CUI [1,2])
C0205435 (UMLS CUI [1,3])
C0205087 (UMLS CUI [1,4])
C0279543 (UMLS CUI [2,1])
C0457343 (UMLS CUI [2,2])
C1279919 (UMLS CUI [2,3])
C4050364 (UMLS CUI [3,1])
C0231175 (UMLS CUI [3,2])
C0935989 (UMLS CUI [4])
C0279543 (UMLS CUI [5,1])
C0332300 (UMLS CUI [5,2])
C0457343 (UMLS CUI [5,3])
C0205435 (UMLS CUI [5,4])
C0279543 (UMLS CUI [6,1])
C0457345 (UMLS CUI [6,2])
C0279543 (UMLS CUI [7,1])
C3899938 (UMLS CUI [7,2])
C1704632 (UMLS CUI [8])
C0005953 (UMLS CUI [9,1])
C0439165 (UMLS CUI [9,2])
C0427540 (UMLS CUI [10])
C0279543 (UMLS CUI [11,1])
C0457343 (UMLS CUI [11,2])
C0935989 (UMLS CUI [12,1])
C1514892 (UMLS CUI [12,2])
C1517945 (UMLS CUI [13,1])
C4050308 (UMLS CUI [13,2])
C3846158 (UMLS CUI [14])
C1517945 (UMLS CUI [15,1])
C4050364 (UMLS CUI [15,2])
Zubrod Performance Status | Creatinine measurement, serum
Item
patients must have a zubrod ps < 3. creatinine < 1.8 mg/dl
boolean
C3714786 (UMLS CUI [1])
C0201976 (UMLS CUI [2])
Serum total bilirubin measurement
Item
serum bilirubin </= 1.5 mg/dl
boolean
C1278039 (UMLS CUI [1])
Alanine aminotransferase measurement
Item
sgpt < 3 x normal values
boolean
C0201836 (UMLS CUI [1])
Sibling HLA Identical | Homologous Transplantation Refused | Ineligibility Homologous Transplantation | Etiology Age
Item
patients with an hla identical sibling are eligible if they refuse allogeneic transplantation, or if they are ineligible for allogeneic transplantation due to age.
boolean
C0037047 (UMLS CUI [1,1])
C0019721 (UMLS CUI [1,2])
C0205280 (UMLS CUI [1,3])
C0040739 (UMLS CUI [2,1])
C1705116 (UMLS CUI [2,2])
C1512714 (UMLS CUI [3,1])
C0040739 (UMLS CUI [3,2])
C0015127 (UMLS CUI [4,1])
C0001779 (UMLS CUI [4,2])
Carbon Monoxide Diffusing Capability Test
Item
dlco >/= 50% of predicted
boolean
C1516251 (UMLS CUI [1])
Cardiac ejection fraction
Item
cardiac ejection fraction >/= 40%
boolean
C0232174 (UMLS CUI [1])
Communicable Diseases Life Threatening Uncontrolled | Comorbidity Impairing Therapeutic procedure
Item
uncontrolled life-threatening infections or comorbid condition that could impair tolerance to the regimen.
boolean
C0009450 (UMLS CUI [1,1])
C2826244 (UMLS CUI [1,2])
C0205318 (UMLS CUI [1,3])
C0009488 (UMLS CUI [2,1])
C0221099 (UMLS CUI [2,2])
C0087111 (UMLS CUI [2,3])
HIV Seropositivity
Item
hiv positivity.
boolean
C0019699 (UMLS CUI [1])
Pregnancy | Breast Feeding
Item
pregnant or lactating women.
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Blastic Phase CML Unresponsive to Treatment | Bone Marrow Percentage | Blast Cells Present in Peripheral Blood
Item
cml in blastic phase that has not responded to therapy given prior to enrollment in this study (characterized by the presence of more than 9% bone marrow and/or peripheral blood blasts at the time of consent signing)
boolean
C0005699 (UMLS CUI [1,1])
C0205269 (UMLS CUI [1,2])
C0005953 (UMLS CUI [2,1])
C0439165 (UMLS CUI [2,2])
C1332566 (UMLS CUI [3])
Hepatitis B | Hepatitis C | Hepatitis B DNA assay positive | Hepatitis B e antigen positive | Hepatitis B surface antigen positive
Item
hepatitis b or c virus infection. hepatitis b infection defined by positive dna test, positive e and / or surface antigen.
boolean
C0019163 (UMLS CUI [1])
C0019196 (UMLS CUI [2])
C1168040 (UMLS CUI [3])
C0392390 (UMLS CUI [4])
C0149709 (UMLS CUI [5])
CML Molecular Complete Response First
Item
cml in first molecular remission.
boolean
C0023473 (UMLS CUI [1,1])
C4050308 (UMLS CUI [1,2])
C0205435 (UMLS CUI [1,3])