Measurable Disease | Evaluable Patient Disease Progression
Item
subjects must have measurable disease or must be evaluable for disease progression
boolean
C1513041 (UMLS CUI [1])
C2986511 (UMLS CUI [2,1])
C0242656 (UMLS CUI [2,2])
Age
Item
age >/= 18 years.
boolean
C0001779 (UMLS CUI [1])
Postmenopausal state
Item
postmenopausal women
boolean
C0232970 (UMLS CUI [1])
ECOG performance status
Item
eastern cooperative oncology group (ecog) performance status (ps) 0 or 1.
boolean
C1520224 (UMLS CUI [1])
Oestrogen receptor positive breast cancer | Breast Carcinoma Progesterone receptor positive | Disease unresectable | Disease Advanced Locally | Neoplasm Metastasis
Item
histologically or cytologically confirmed er and/or pgr positive carcinoma of the breast with unresectable, locally advanced and/or metastatic disease
boolean
C2938924 (UMLS CUI [1])
C0678222 (UMLS CUI [2,1])
C0279759 (UMLS CUI [2,2])
C0012634 (UMLS CUI [3,1])
C1519810 (UMLS CUI [3,2])
C0012634 (UMLS CUI [4,1])
C0205179 (UMLS CUI [4,2])
C1517927 (UMLS CUI [4,3])
C0027627 (UMLS CUI [5])
Prior Hormone Therapy Breast Carcinoma | anastrozole | letrozole | Tamoxifen
Item
subjects must have received prior hormonal therapy for the treatment of breast cancer (anastrozole, letrozole, or tamoxifen)
boolean
C1514460 (UMLS CUI [1,1])
C0678222 (UMLS CUI [1,2])
C0290883 (UMLS CUI [2])
C0246421 (UMLS CUI [3])
C0039286 (UMLS CUI [4])
Hematologic function | Liver function | Renal function
Item
adequate hematologic, hepatic, and renal function
boolean
C0221130 (UMLS CUI [1])
C0232741 (UMLS CUI [2])
C0232804 (UMLS CUI [3])
exemestane | pazopanib
Item
prior use of exemestane or pazopanib
boolean
C0851344 (UMLS CUI [1])
C1831796 (UMLS CUI [2])
Premenopausal state
Item
premenopausal women
boolean
C0232969 (UMLS CUI [1])
Cancer treatment | Toxicity CTCAE Grades | Toxicity Severitiy Progressing
Item
any ongoing toxicity from prior anti-cancer therapy that is >grade 1 and/or that is progressing in severity.
boolean
C0920425 (UMLS CUI [1])
C0600688 (UMLS CUI [2,1])
C1516728 (UMLS CUI [2,2])
C0600688 (UMLS CUI [3,1])
C0439793 (UMLS CUI [3,2])
C0205329 (UMLS CUI [3,3])
Vascular Endothelial Growth Factor Inhibitors
Item
prior therapy with a vegf inhibitor.
boolean
C2267120 (UMLS CUI [1])
Investigational New Drugs | Antineoplastic Agents Investigational
Item
use of an investigational agent, including an investigational anti-cancer agent, within 28 days or 5 half-lives, whichever is longer, prior to the first dose of investigational product.
boolean
C0013230 (UMLS CUI [1])
C0003392 (UMLS CUI [2,1])
C1517586 (UMLS CUI [2,2])
Recurrent disease | Disease Due to Malignant Neoplasms
Item
evidence of recurrence or active disease from prior malignancy.
boolean
C0277556 (UMLS CUI [1])
C0012634 (UMLS CUI [2,1])
C0678226 (UMLS CUI [2,2])
C0006826 (UMLS CUI [2,3])
Abnormality of the gastrointestinal tract At risk Gastrointestinal Hemorrhage | Abnormality of the gastrointestinal tract Affecting Absorption Investigational New Drugs
Item
clinically significant gastrointestinal abnormalities that may increase the risk for gi bleeding or affect the absorption of the investigational product(s).
boolean
C4023588 (UMLS CUI [1,1])
C1444641 (UMLS CUI [1,2])
C0017181 (UMLS CUI [1,3])
C4023588 (UMLS CUI [2,1])
C0392760 (UMLS CUI [2,2])
C0237442 (UMLS CUI [2,3])
C0013230 (UMLS CUI [2,4])
Communicable Disease Uncontrolled
Item
presence of uncontrolled infection.
boolean
C0009450 (UMLS CUI [1,1])
C0205318 (UMLS CUI [1,2])
Cardiovascular Disease Major
Item
history of any major cardiovascular conditions within the past 6 months:
boolean
C0007222 (UMLS CUI [1,1])
C0205164 (UMLS CUI [1,2])
Hypertensive disease Poorly controlled
Item
poorly controlled hypertension
boolean
C0020538 (UMLS CUI [1,1])
C3853134 (UMLS CUI [1,2])
Cerebrovascular accident | Pulmonary Embolism | Deep Vein Thrombosis untreated
Item
history of cerebrovascular accident, pulmonary embolism or untreated deep venous thrombosis (dvt) within the past 6 months.
boolean
C0038454 (UMLS CUI [1])
C0034065 (UMLS CUI [2])
C0149871 (UMLS CUI [3,1])
C0332155 (UMLS CUI [3,2])
Major surgery | Trauma | Wound, non-healed | Fracture | Ulcer
Item
prior major surgery or trauma within 28 days prior to first dose of investigational product and/or presence of any non-healing wound, fracture, or ulcer
boolean
C0679637 (UMLS CUI [1])
C3714660 (UMLS CUI [2])
C0750433 (UMLS CUI [3])
C0016658 (UMLS CUI [4])
C0041582 (UMLS CUI [5])
Hemorrhage | Bleeding tendency
Item
evidence of active bleeding or bleeding tendency.
boolean
C0019080 (UMLS CUI [1])
C1458140 (UMLS CUI [2])