Age
Item
over 18 years of age
boolean
C0001779 (UMLS CUI [1])
Chronic heart failure Severe New York Heart Association Classification | Chronic heart failure New York Heart Association Classification | Hospitalization Quantity Heart failure
Item
severe chronic heart failure (chf) with nyha class iii-iv or nyha class ii with at least one hospitalisation for hf within the last 12 months
boolean
C0264716 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
C1275491 (UMLS CUI [1,3])
C0264716 (UMLS CUI [2,1])
C1275491 (UMLS CUI [2,2])
C0019993 (UMLS CUI [3,1])
C1265611 (UMLS CUI [3,2])
C0018801 (UMLS CUI [3,3])
Left ventricular ejection fraction Echocardiography | Left ventricular ejection fraction Radionuclide Angiography | Left ventricular ejection fraction Left ventriculography | Left ventricular ejection fraction MRI of Heart
Item
left ventricular ejection fraction (lvef) <40% by means of echocardiography, radionucleotide angiography, left ventriculography or cardiac mri documented less than 12 weeks before randomisation
boolean
C0428772 (UMLS CUI [1,1])
C0013516 (UMLS CUI [1,2])
C0428772 (UMLS CUI [2,1])
C0034604 (UMLS CUI [2,2])
C0428772 (UMLS CUI [3,1])
C0412219 (UMLS CUI [3,2])
C0428772 (UMLS CUI [4,1])
C0412692 (UMLS CUI [4,2])
Sleep Apnea Syndromes Apnea Hypopnea Index
Item
diagnosis of sleep disordered breathing sdb (apnoea-hypopnoea-index (ahi >15/h) with
boolean
C0037315 (UMLS CUI [1,1])
C4083070 (UMLS CUI [1,2])
Event Main Percentage Apnea Hypopnea Index
Item
≥ 50% central events and a central ahi ≥ 10/h)
boolean
C0441471 (UMLS CUI [1,1])
C1542147 (UMLS CUI [1,2])
C0439165 (UMLS CUI [1,3])
C4083070 (UMLS CUI [1,4])
Stable status Clinical | Pharmaceutical Preparations unchanged | Hospitalization Absent
Item
clinically stable with no change in medication and no hospitalisation in preceding month
boolean
C0205360 (UMLS CUI [1,1])
C0205210 (UMLS CUI [1,2])
C0013227 (UMLS CUI [2,1])
C0442739 (UMLS CUI [2,2])
C0019993 (UMLS CUI [3,1])
C0332197 (UMLS CUI [3,2])
Therapeutic procedure Optimization
Item
optimised medical treatment according to the applicable guidelines
boolean
C0087111 (UMLS CUI [1,1])
C2698650 (UMLS CUI [1,2])
Informed Consent
Item
able to provide informed consent
boolean
C0021430 (UMLS CUI [1])
Chronic Obstructive Airway Disease | FEV1
Item
significant chronic obstructive pulmonary disease (copd) with forced expiratory volume within one second (fev1) <50%
boolean
C0024117 (UMLS CUI [1])
C0849974 (UMLS CUI [2])
Oxygen saturation measurement At rest
Item
oxygen saturation at rest during the day ≤ 90% at inclusion
boolean
C0523807 (UMLS CUI [1,1])
C0443144 (UMLS CUI [1,2])
Continuous Positive Airway Pressure
Item
current use of positive airway pressure (pap) therapy
boolean
C0199451 (UMLS CUI [1])
Life Expectancy | Relationship Chronic heart failure Absent
Item
life expectancy < 1 year for diseases unrelated to chronic heart failure
boolean
C0023671 (UMLS CUI [1])
C0439849 (UMLS CUI [2,1])
C0264716 (UMLS CUI [2,2])
C0332197 (UMLS CUI [2,3])
Cardiac Surgery procedures | Percutaneous Coronary Intervention | Myocardial Infarction | Angina, Unstable
Item
cardiac surgery, percutaneous coronary intervention (pci), myocardial infarction (mi) or unstable angina within 6 months prior to randomisation
boolean
C0018821 (UMLS CUI [1])
C1532338 (UMLS CUI [2])
C0027051 (UMLS CUI [3])
C0002965 (UMLS CUI [4])
Implantable defibrillator insertion Scheduled | Cardiac Resynchronization Therapy Scheduled | Implantable defibrillator insertion | Cardiac Resynchronization Therapy
Item
implantation of icd (implanted cardiodefibrillator) or crt (cardiac resynchronisation therapy) scheduled or within 6 months prior to randomisation
boolean
C0877213 (UMLS CUI [1,1])
C0205539 (UMLS CUI [1,2])
C1167956 (UMLS CUI [2,1])
C0205539 (UMLS CUI [2,2])
C0877213 (UMLS CUI [3])
C1167956 (UMLS CUI [4])
Transient Ischemic Attack | Cerebrovascular accident
Item
transient ischemic attack (tia) or stroke within 3 months prior to randomisation
boolean
C0007787 (UMLS CUI [1])
C0038454 (UMLS CUI [2])
Heart valve disease (obstructive) (regurgitation) uncorrected | Valvular disease Resulting in Operative Surgical Procedures
Item
primary hemodynamically significant uncorrected valvular heart disease, obstructive or regurgitant, or any valvular disease expected to lead to surgery during the trial
boolean
C1399139 (UMLS CUI [1,1])
C4072785 (UMLS CUI [1,2])
C3258293 (UMLS CUI [2,1])
C0332294 (UMLS CUI [2,2])
C0543467 (UMLS CUI [2,3])
Myocarditis | Pericarditis
Item
acute myocarditis/pericarditis within 6 months prior to randomisation
boolean
C0027059 (UMLS CUI [1])
C0031046 (UMLS CUI [2])
Restless Legs Syndrome untreated | Restless Legs Syndrome refractory
Item
untreated or therapy refractory restless legs syndrome (rls)
boolean
C0035258 (UMLS CUI [1,1])
C0332155 (UMLS CUI [1,2])
C0035258 (UMLS CUI [2,1])
C0205269 (UMLS CUI [2,2])
Pregnancy
Item
pregnancy
boolean
C0032961 (UMLS CUI [1])