Age | Primary hypercholesterolemia | Lifestyle change therapy Unsatisfactory | Serum LDL cholesterol measurement High risk
Item
the patients aged 20 to 79 years with primary hypercholesterolemia that was not sufficiently responsive to therapeutic lifestyle changes and had ldl-c level over 100 mg/dl in high risk group.
boolean
C0001779 (UMLS CUI [1])
C0342879 (UMLS CUI [2])
C2960841 (UMLS CUI [3,1])
C0439856 (UMLS CUI [3,2])
C0428474 (UMLS CUI [4,1])
C0332167 (UMLS CUI [4,2])
Coronary Artery Disease | Serum LDL cholesterol measurement | Risk factors Quantity | Lifestyle change therapy
Item
inclusion criteria was in accordance with drug treatment guidelines; coronary artery disease or equivalent group with ldl-c ≥100 mg/dl; patients with two or more risk factors and ldl-c≥130 mg/dl; patients with 0 or 1 risk factor and ldl-c >160 mg/dl after therapeutic lifestyle changes
boolean
C1956346 (UMLS CUI [1])
C0428474 (UMLS CUI [2])
C0035648 (UMLS CUI [3,1])
C1265611 (UMLS CUI [3,2])
C2960841 (UMLS CUI [4])
Investigational New Drugs
Item
therapy with any other investigational drug within 30 days of randomization,
boolean
C0013230 (UMLS CUI [1])
HMG COA reductase inhibitor allergy
Item
history of hypersensitivity to hmg-coa reductase inhibitors,
boolean
C0571873 (UMLS CUI [1])
Uncontrolled hypertension
Item
uncontrolled hypertension,
boolean
C1868885 (UMLS CUI [1])
Poorly controlled diabetes mellitus | Glucohemoglobin measurement
Item
poorly controlled diabetes (glycosylated hemoglobin [hba1c] >9%),
boolean
C0554876 (UMLS CUI [1])
C0202054 (UMLS CUI [2])
Angina, Unstable | Myocardial Infarction New onset
Item
unstable angina or presented with new-onset myocardial infarction (within 6 months),
boolean
C0002965 (UMLS CUI [1])
C0027051 (UMLS CUI [2,1])
C0746890 (UMLS CUI [2,2])
Creatinine measurement, serum
Item
creatinine >2.5 mg/dl,
boolean
C0201976 (UMLS CUI [1])
Alanine aminotransferase increased | Aspartate aminotransferase increased | Elevated creatine kinase
Item
alanine aminotransferase (alt) >2 x upper limit of normal (uln), aspartate aminotransferase(ast) >2 x uln, or creatine kinase (ck) >2 x uln,
boolean
C0151905 (UMLS CUI [1])
C0151904 (UMLS CUI [2])
C0151576 (UMLS CUI [3])
Malignant Neoplasms | Psychotic Disorders
Item
history of malignancy or psychosis;
boolean
C0006826 (UMLS CUI [1])
C0033975 (UMLS CUI [2])
Chronic liver disease
Item
chronic liver disease,
boolean
C0341439 (UMLS CUI [1])
Substance Use Disorders | Pregnancy | Breast Feeding | Contraceptive methods failed | Contraceptives, Oral, Hormonal | Hormone replacement therapy
Item
drug or alcohol abuse, pregnancy, breastfeeding, failure to practice adequate contraception, cyclical hormonal contraceptives or intermittent use of hormone replacement therapies.
boolean
C0038586 (UMLS CUI [1])
C0032961 (UMLS CUI [2])
C0006147 (UMLS CUI [3])
C0700589 (UMLS CUI [4,1])
C0231175 (UMLS CUI [4,2])
C0009907 (UMLS CUI [5])
C0282402 (UMLS CUI [6])