Dyslipidemia | High risk of Cardiovascular Disease | Serum LDL cholesterol measurement | Coronary Artery Disease
Item
1. dyslipidemic patients with high-risk cardiovascular disease meeting more than 1 requirement below (ldl-c ≥ 100mg/dl) 1) coronary artery disease
boolean
C0242339 (UMLS CUI [1])
C0332167 (UMLS CUI [2,1])
C0007222 (UMLS CUI [2,2])
C0428474 (UMLS CUI [3])
C1956346 (UMLS CUI [4])
Atheroma CT Coronary | Atheroma Coronary angiography | SPECT Positive | Treadmill Test Positive | Diabetes Mellitus | Placement of stent Previous Coronary Artery Disease | Carotid Atherosclerosis | Peripheral Arterial Diseases
Item
diagnosed with atheroma in coronary ct or angiography, or spect positive or treadmill test positive 2) diabetes mellitus 3) intervened with stent in coronary artery disease more than 1 year before 4) diagnosed with atheroma in carotid artery 5) peripheral artery disease
boolean
C0264956 (UMLS CUI [1,1])
C0040405 (UMLS CUI [1,2])
C1522318 (UMLS CUI [1,3])
C0264956 (UMLS CUI [2,1])
C0085532 (UMLS CUI [2,2])
C0040399 (UMLS CUI [3,1])
C1514241 (UMLS CUI [3,2])
C0087110 (UMLS CUI [4,1])
C1514241 (UMLS CUI [4,2])
C0011849 (UMLS CUI [5])
C0522776 (UMLS CUI [6,1])
C0205156 (UMLS CUI [6,2])
C1956346 (UMLS CUI [6,3])
C0577631 (UMLS CUI [7])
C1704436 (UMLS CUI [8])
Age
Item
2. aged 20~85 years
boolean
C0001779 (UMLS CUI [1])
Informed Consent
Item
3. volunteers consented with participating clinical trial and submitted consent paper
boolean
C0021430 (UMLS CUI [1])
Liver disease | Aspartate aminotransferase increased | Alanine aminotransferase increased | Elevated creatine kinase | Creatinine measurement, serum | Triglycerides measurement
Item
1. experimental examination at screening 1) active liver disease or more than 2 x uln of ast/alt 2) creatine kinase > 2 x uln 3) creatinine > 2.5mg/dl 4) triglycerides > 500mg/dl
boolean
C0023895 (UMLS CUI [1])
C0151904 (UMLS CUI [2])
C0151905 (UMLS CUI [3])
C0151576 (UMLS CUI [4])
C0201976 (UMLS CUI [5])
C0202236 (UMLS CUI [6])
Placement of stent Coronary Artery Disease
Item
2. intervened with stent in coronary artery disease less than 1 year before
boolean
C0522776 (UMLS CUI [1,1])
C1956346 (UMLS CUI [1,2])
HMG COA reductase inhibitor allergy | Statins Resistant | Serious Adverse Event
Item
3. hyper-sensitive or resistant to other hmg-coa reductase inhibitors, or experienced serious adverse events
boolean
C0571873 (UMLS CUI [1])
C0360714 (UMLS CUI [2,1])
C0332325 (UMLS CUI [2,2])
C1519255 (UMLS CUI [3])
Therapeutic procedure Dyslipidemia | Statins | Fibrates | Nicotinic Acids | Bile-acid Binding Resin
Item
4. patients taking dyslipidemic treatments within 4 weeks (hmg-coa reductase inhibitors, fibrates, nicotinic acids or bile acid resins, etc.)
boolean
C0087111 (UMLS CUI [1,1])
C0242339 (UMLS CUI [1,2])
C0360714 (UMLS CUI [2])
C1449704 (UMLS CUI [3])
C0028049 (UMLS CUI [4])
C2266924 (UMLS CUI [5])
Diabetic - poor control | Glucohemoglobin measurement | Plasma fasting glucose measurement
Item
5. as uncontrolled dm patients, hba1c≥11% or fasting plasma glucose ≥200mg/dl
boolean
C0421258 (UMLS CUI [1])
C0202054 (UMLS CUI [2])
C0583513 (UMLS CUI [3])
Diastolic blood pressure | Systolic Pressure
Item
6. dbp > 100mmhg, sbp > 160mmhg
boolean
C0428883 (UMLS CUI [1])
C0871470 (UMLS CUI [2])
Myopathy
Item
7. diagnosed with myopathy
boolean
C0026848 (UMLS CUI [1])
At risk Myopathy
Item
8. appear to be a risk of myopathy below
boolean
C1444641 (UMLS CUI [1,1])
C0026848 (UMLS CUI [1,2])
Renal Insufficiency | Renal dysfunction
Item
renal impairment or prior renal dysfunction
boolean
C1565489 (UMLS CUI [1])
C3279454 (UMLS CUI [2])
Hypothyroidism
Item
hypothyroidism
boolean
C0020676 (UMLS CUI [1])
Defect Genetic Myopathy | Family history Myopathy
Item
genetic defects or family history of myopathy
boolean
C1457869 (UMLS CUI [1,1])
C0314603 (UMLS CUI [1,2])
C0026848 (UMLS CUI [1,3])
C0241889 (UMLS CUI [2,1])
C0026848 (UMLS CUI [2,2])
Muscle Toxicity | Statins | Fibrates
Item
experienced prior muscle toxicity with taking statins or fibrates
boolean
C0026845 (UMLS CUI [1,1])
C0600688 (UMLS CUI [1,2])
C0360714 (UMLS CUI [2])
C1449704 (UMLS CUI [3])
Liver disease | Alcohol consumption High
Item
prior liver disease or higher intakes of alcohol
boolean
C0023895 (UMLS CUI [1])
C0001948 (UMLS CUI [2,1])
C0205250 (UMLS CUI [2,2])
Age | At risk Myopathy
Item
aged over 70, and a risk of myopathy
boolean
C0001779 (UMLS CUI [1])
C1444641 (UMLS CUI [2,1])
C0026848 (UMLS CUI [2,2])
Pregnancy | Breast Feeding
Item
9. women pregnant or breast-feeding
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Childbearing Potential Contraceptive methods Absent
Item
10. women capable of pregnancy without using contraceptives
boolean
C3831118 (UMLS CUI [1,1])
C0700589 (UMLS CUI [1,2])
C0332197 (UMLS CUI [1,3])
Medical contraindication | Contraindication mental | illegal
Item
11. contra-indicated medically or mentally, or forbidden legally
boolean
C1301624 (UMLS CUI [1])
C0522473 (UMLS CUI [2,1])
C0229992 (UMLS CUI [2,2])
C3242151 (UMLS CUI [3])
Study Subject Participation Status
Item
12. enrolled to other clinical trial within 4 weeks
boolean
C2348568 (UMLS CUI [1])
Study Subject Participation Status Excluded
Item
13. impossible to participate clinical trial according to investigator's decision
boolean
C2348568 (UMLS CUI [1,1])
C0332196 (UMLS CUI [1,2])