Healthy Control
Item
for healthy control subjects:
boolean
C2986479 (UMLS CUI [1])
Age | Match Age Related | Match Gender Related | Match Tobacco use Related
Item
men and women aged over 18 years, matched in regard to age, sex and smoking status
boolean
C0001779 (UMLS CUI [1])
C1708943 (UMLS CUI [2,1])
C0001779 (UMLS CUI [2,2])
C0439849 (UMLS CUI [2,3])
C1708943 (UMLS CUI [3,1])
C0079399 (UMLS CUI [3,2])
C0439849 (UMLS CUI [3,3])
C1708943 (UMLS CUI [4,1])
C0543414 (UMLS CUI [4,2])
C0439849 (UMLS CUI [4,3])
Finding Normal Medical History | Finding Normal Physical Examination
Item
normal findings in the medical history and physical examination unless the investigator considers an abnormality to be clinically irrelevant
boolean
C0243095 (UMLS CUI [1,1])
C0205307 (UMLS CUI [1,2])
C0262926 (UMLS CUI [1,3])
C0243095 (UMLS CUI [2,1])
C0205307 (UMLS CUI [2,2])
C0031809 (UMLS CUI [2,3])
Normal Laboratory Test Result
Item
normal laboratory values unless the investigator considers an abnormality to be clinically irrelevant
boolean
C0438214 (UMLS CUI [1])
Ophthalmological examination normal | Ametropia Diopters Quantity Healthy Control
Item
normal ophthalmic findings, ametropia < 3 dpt for healthy control subjects
boolean
C1112543 (UMLS CUI [1])
C1527310 (UMLS CUI [2,1])
C0439484 (UMLS CUI [2,2])
C1265611 (UMLS CUI [2,3])
C2986479 (UMLS CUI [2,4])
Patients Insulin-Dependent Diabetes Mellitus
Item
for patients with iddm:
boolean
C0030705 (UMLS CUI [1,1])
C0011854 (UMLS CUI [1,2])
Age
Item
men and women aged over 18 years
boolean
C0001779 (UMLS CUI [1])
Finding Normal Medical History | Finding Normal Physical Examination
Item
normal findings in the medical history and physical examination unless the investigator considers an abnormality to be clinically irrelevant
boolean
C0243095 (UMLS CUI [1,1])
C0205307 (UMLS CUI [1,2])
C0262926 (UMLS CUI [1,3])
C0243095 (UMLS CUI [2,1])
C0205307 (UMLS CUI [2,2])
C0031809 (UMLS CUI [2,3])
Insulin-Dependent Diabetes Mellitus Disease length
Item
long standing iddm > 10 years
boolean
C0011854 (UMLS CUI [1,1])
C0872146 (UMLS CUI [1,2])
Mild non-proliferative diabetic retinopathy | Moderate nonproliferative diabetic retinopathy | Severe nonproliferative diabetic retinopathy
Item
mild or moderate to severe non-proliferative diabetic retinopathy (defined according to the mahc)
boolean
C0730276 (UMLS CUI [1])
C0730277 (UMLS CUI [2])
C0730278 (UMLS CUI [3])
Ametropia Diopters Quantity
Item
ametropia < 3 dpt
boolean
C1527310 (UMLS CUI [1,1])
C0439484 (UMLS CUI [1,2])
C1265611 (UMLS CUI [1,3])
Exclusion Criteria Healthy Subjects
Item
any of the following will exclude a healthy subject from the study:
boolean
C0680251 (UMLS CUI [1,1])
C1708335 (UMLS CUI [1,2])
Vasoactive agent Regular | Interference Clinical Trial Procedure | Alcohol abuse | Study Subject Participation Status
Item
regular use of vasoactive medication with may interfere with the study procedure, abuse of alcoholic beverages, participation in a clinical trial in the 3 weeks preceding the study
boolean
C0597639 (UMLS CUI [1,1])
C0205272 (UMLS CUI [1,2])
C0521102 (UMLS CUI [2,1])
C0008976 (UMLS CUI [2,2])
C0184661 (UMLS CUI [2,3])
C0085762 (UMLS CUI [3])
C2348568 (UMLS CUI [4])
Symptoms Illness Relevant Clinical
Item
symptoms of a clinically relevant illness in the 3 weeks before the first study day
boolean
C1457887 (UMLS CUI [1,1])
C0221423 (UMLS CUI [1,2])
C2347946 (UMLS CUI [1,3])
C0205210 (UMLS CUI [1,4])
Blood Donation
Item
blood donation during the previous 3 weeks
boolean
C0005794 (UMLS CUI [1])
Exclusion Criteria Patients Insulin-Dependent Diabetes Mellitus
Item
any of the following will exclude a patient with iddm from the study:
boolean
C0680251 (UMLS CUI [1,1])
C0030705 (UMLS CUI [1,2])
C0011854 (UMLS CUI [1,3])
Retinal Diseases | Choroid Diseases | Glaucoma | Age related macular degeneration | Cataract | Central Retinal Artery Occlusion | Central retinal vein occlusion
Item
evidence of any relevant retinal or choroidal disease (glaucoma, age related macula degeneration, cataract, history of central retinal artery obstruction or central retinal vein thrombosis)
boolean
C0035309 (UMLS CUI [1])
C0008521 (UMLS CUI [2])
C0017601 (UMLS CUI [3])
C0242383 (UMLS CUI [4])
C0086543 (UMLS CUI [5])
C0007688 (UMLS CUI [6])
C0154841 (UMLS CUI [7])
Ophthalmologic Surgical Procedures | Laser photocoagulation | Argon laser trabeculoplasty | Trabeculectomy | Deep sclerectomy
Item
ophthalmological surgery (history of photo laser coagulation, including argon laser trabeculoplasty (alt), trabeculectomy, deep sclerectomy)
boolean
C0038901 (UMLS CUI [1])
C0441510 (UMLS CUI [2])
C1319234 (UMLS CUI [3])
C0040574 (UMLS CUI [4])
C1531790 (UMLS CUI [5])
Intravitreal Injection | Antineoplastic Agents
Item
history of intravitreal injection with anti-proliferative therapy
boolean
C1554888 (UMLS CUI [1])
C0003392 (UMLS CUI [2])
Patient need for Dialysis
Item
need for dialysis
boolean
C0686904 (UMLS CUI [1,1])
C0011946 (UMLS CUI [1,2])
Hypertensive disease untreated | Systolic Pressure | Diastolic blood pressure
Item
non-treated systemic hypertension (spb>150, dbp>95)
boolean
C0020538 (UMLS CUI [1,1])
C0332155 (UMLS CUI [1,2])
C0871470 (UMLS CUI [2])
C0428883 (UMLS CUI [3])
Coronary heart disease | Cardiomyopathy | Angina Pectoris | Congestive heart failure | Peripheral occlusive vascular disorder | Cardiac autonomic neuropathy
Item
evidence of coronary heart disease, cardiomyopathy, stenocardia, congestive heart failure, peripheral occlusive vascular disease, cardiac autonomic neuropathy
boolean
C0010068 (UMLS CUI [1])
C0878544 (UMLS CUI [2])
C0002962 (UMLS CUI [3])
C0018802 (UMLS CUI [4])
C1385232 (UMLS CUI [5])
C1740787 (UMLS CUI [6])
Symptoms Illness Relevant Clinical
Item
symptoms of a clinically relevant illness in the 3 weeks before the first study day
boolean
C1457887 (UMLS CUI [1,1])
C0221423 (UMLS CUI [1,2])
C2347946 (UMLS CUI [1,3])
C0205210 (UMLS CUI [1,4])
Blood Donation
Item
blood donation during the previous 3 weeks
boolean
C0005794 (UMLS CUI [1])