Non-Insulin-Dependent Diabetes Mellitus Disease length
Item
type 2 diabetes mellitus >3 months by history prior to entering the trial, based on disease diagnostic criteria from the american diabetes association (ada 2007).
boolean
C0011860 (UMLS CUI [1,1])
C0872146 (UMLS CUI [1,2])
Age | Gender Pregnancy test negative | Gender Contraceptive methods
Item
men or women 18 years of age or older. women must have a negative pregnancy test and be willing to use birth control during study duration and one month post.
boolean
C0001779 (UMLS CUI [1])
C0079399 (UMLS CUI [2,1])
C0427780 (UMLS CUI [2,2])
C0079399 (UMLS CUI [3,1])
C0700589 (UMLS CUI [3,2])
Glucohemoglobin measurement
Item
have glycosylated hemoglobin (hba1c) of >7.0% to ≤10.5% as determined by central laboratory at screening.
boolean
C0202054 (UMLS CUI [1])
Body mass index
Item
have a body mass index (bmi) between 27 and 40 kilograms/meter squared (kg/m^2), inclusive.
boolean
C1305855 (UMLS CUI [1])
Oral hypoglycemic Dosage Same Combination | Sulfonylurea | Chlorpropamide | Diabinese | glimepiride | Amaryl | Tolbutamide | Orinase | Tolazamide | Tolinase | Glipizide | Glucotrol | Glyburide | Micronase | Diabeta | Glynase | Biguanides | Glucophage | Metformin | Thiazolidinediones | rosiglitazone | Avandia | pioglitazone | Actos | Dipeptidyl-Peptidase IV Inhibitors | sitagliptin | Januvia | Metaglip | Glucovance | Duetact | Janumet
Item
have been on the same doses for 3 months of any approved combination of 2 oral antihyperglycemic medications in any combination of the following: sulfonylureas (e.g. chlorpropamide or diabinese, glimepiride or amaryl, tolbutamide or orinase, tolazamide or tolinase, glipizide or glucotrol, glyburide also known as micronase, diabeta, or glynase), biguanides (e.g. glucophage or metformin), thiazolidinediones (e.g. rosiglitazone or avandia, or pioglitazone or actos), or dipeptidyl peptidase 4 (dpp-iv) inhibitors (e.g. sitagliptin or januvia). a combination pill of any 2 of these drugs is allowed (1 only), (e.g. metformin and glipizide or metaglip), (e.g. metformin and glyburide or glucovance), (e.g. pioglitazone and glimepiride or duetact), or (e.g. sitagliptin and metformin or janumet).
boolean
C0359086 (UMLS CUI [1,1])
C0178602 (UMLS CUI [1,2])
C0445247 (UMLS CUI [1,3])
C0205195 (UMLS CUI [1,4])
C0038766 (UMLS CUI [2])
C0008287 (UMLS CUI [3])
C0591359 (UMLS CUI [4])
C0061323 (UMLS CUI [5])
C0595112 (UMLS CUI [6])
C0040374 (UMLS CUI [7])
C0701229 (UMLS CUI [8])
C0040372 (UMLS CUI [9])
C0723773 (UMLS CUI [10])
C0017642 (UMLS CUI [11])
C0701228 (UMLS CUI [12])
C0017628 (UMLS CUI [13])
C0700712 (UMLS CUI [14])
C0700718 (UMLS CUI [15])
C2725379 (UMLS CUI [16])
C0005382 (UMLS CUI [17])
C0591573 (UMLS CUI [18])
C0025598 (UMLS CUI [19])
C1257987 (UMLS CUI [20])
C0289313 (UMLS CUI [21])
C0875967 (UMLS CUI [22])
C0071097 (UMLS CUI [23])
C0875954 (UMLS CUI [24])
C1827106 (UMLS CUI [25])
C1565750 (UMLS CUI [26])
C1702177 (UMLS CUI [27])
C1170394 (UMLS CUI [28])
C0939344 (UMLS CUI [29])
C1735398 (UMLS CUI [30])
C1948387 (UMLS CUI [31])
Diabetes Mellitus, Insulin-Dependent
Item
have known type 1 diabetes mellitus
boolean
C0011854 (UMLS CUI [1])
Glucagon-Like Peptide 1 | Glucagon-Like Peptide 1 Analog | Byetta
Item
have taken glucagon-like peptide-1 (glp-1) or any glp-1 analog drug (byetta)
boolean
C0061355 (UMLS CUI [1])
C0061355 (UMLS CUI [2,1])
C0243071 (UMLS CUI [2,2])
C1636686 (UMLS CUI [3])
Angina, Unstable | Myocardial Infarction | Ventricular arrhythmia | Congestive heart failure | Intervention Coronary | Percutaneous Transluminal Coronary Angioplasty | Open heart surgery | Coronary Artery Bypass Surgery | Transient Ischemic Attack | Cerebrovascular accident
Item
have a history of unstable angina, heart attack (myocardial infarction), heart arrhythmia (ventricular), congestive heart failure, or other coronary intervention (percutaneous transluminal coronary angioplasty [ptca], open heart surgery, or coronary artery bypass graft [cabg]), a transient ischemic attack (tia) or stroke (cerebrovascular accident) in the last 6 months prior to screening.
boolean
C0002965 (UMLS CUI [1])
C0027051 (UMLS CUI [2])
C0085612 (UMLS CUI [3])
C0018802 (UMLS CUI [4])
C0184661 (UMLS CUI [5,1])
C1522318 (UMLS CUI [5,2])
C2936173 (UMLS CUI [6])
C0189745 (UMLS CUI [7])
C0010055 (UMLS CUI [8])
C0007787 (UMLS CUI [9])
C0038454 (UMLS CUI [10])
Hepatitis | Hepatitis, Chronic | Increased liver function tests | Alanine aminotransferase increased | Pancreatitis, Chronic | Kidney Diseases | Creatinine measurement, serum | Relationship Biguanides | Relationship Metformin | Relationship Glucophage | Relationship Dipeptidyl-Peptidase IV Inhibitors | Relationship sitagliptin | Relationship Januvia | Relationship Janumet
Item
have acute or chronic hepatitis or elevated liver function tests (alanine transaminase), a history of chronic or recurrent pancreatitis. have renal disease or a serum creatinine (blood test) >2 milligrams per deciliter (mg/dl). if taking biguanides (e.g. metformin or glucophage), or dpp-iv inhibitors (e.g. sitagliptin or januvia or janumet), creatinine must be ≤1.5 mg/dl.
boolean
C0019158 (UMLS CUI [1])
C0019189 (UMLS CUI [2])
C0877359 (UMLS CUI [3])
C0151905 (UMLS CUI [4])
C0149521 (UMLS CUI [5])
C0022658 (UMLS CUI [6])
C0201976 (UMLS CUI [7])
C0439849 (UMLS CUI [8,1])
C0005382 (UMLS CUI [8,2])
C0439849 (UMLS CUI [9,1])
C0025598 (UMLS CUI [9,2])
C0439849 (UMLS CUI [10,1])
C0591573 (UMLS CUI [10,2])
C0439849 (UMLS CUI [11,1])
C1827106 (UMLS CUI [11,2])
C0439849 (UMLS CUI [12,1])
C1565750 (UMLS CUI [12,2])
C0439849 (UMLS CUI [13,1])
C1702177 (UMLS CUI [13,2])
C0439849 (UMLS CUI [14,1])
C1948387 (UMLS CUI [14,2])
Weight-Loss Agents Drug Prescriptions | Weight-Loss Agents Non-Prescription Drugs
Item
currently taking prescription or over the counter medications to prevent weight loss.
boolean
C0376606 (UMLS CUI [1,1])
C0033081 (UMLS CUI [1,2])
C0376606 (UMLS CUI [2,1])
C0013231 (UMLS CUI [2,2])