Age | Ethnic group All
Item
12 to 19 years old (inclusive) of both sexes and all ethnic/racial groups.
boolean
C0001779 (UMLS CUI [1])
C0015031 (UMLS CUI [2,1])
C0444868 (UMLS CUI [2,2])
Major Depressive Disorder
Item
dsm-iv-tr criteria for mdd
boolean
C1269683 (UMLS CUI [1])
Major Depressive Disorder Duration | MDD Depression in children Rating scale
Item
mdd duration of at least 8 weeks and a severity score of at least 40 on the cdrs-r.
boolean
C1269683 (UMLS CUI [1,1])
C0449238 (UMLS CUI [1,2])
C1269683 (UMLS CUI [2,1])
C3826462 (UMLS CUI [2,2])
C0681889 (UMLS CUI [2,3])
Age | MDD Onset First
Item
age at first onset mdd of at least 12 years.
boolean
C0001779 (UMLS CUI [1])
C1269683 (UMLS CUI [2,1])
C0332162 (UMLS CUI [2,2])
C0205435 (UMLS CUI [2,3])
Disease Significant Absent | Nervous system disorder Absent
Item
no significant medical or neurological disorder
boolean
C0012634 (UMLS CUI [1,1])
C0750502 (UMLS CUI [1,2])
C0332197 (UMLS CUI [1,3])
C0027765 (UMLS CUI [2,1])
C0332197 (UMLS CUI [2,2])
Gender | Pregnancy test negative
Item
for female subjects, negative pregnancy test at time of enrollment.
boolean
C0079399 (UMLS CUI [1])
C0427780 (UMLS CUI [2])
Gender | Contraceptives, Oral, Hormonal | Contraceptives, Oral | Subdermal Birth Control Implant | Exclusion Sexually active Contraceptive methods Lacking
Item
female subjects who are sexually active and not using a method of birth control will be excluded. use of hormonal contraceptives (such as prescribed "birth control pills" or a prescribed birth control implant) is not exclusionary.
boolean
C0079399 (UMLS CUI [1])
C0009907 (UMLS CUI [2])
C0009905 (UMLS CUI [3])
C2985332 (UMLS CUI [4])
C2828389 (UMLS CUI [5,1])
C0241028 (UMLS CUI [5,2])
C0700589 (UMLS CUI [5,3])
C0332268 (UMLS CUI [5,4])
Able to swallow Capsules
Item
subjects must be able to swallow capsules.
boolean
C2712086 (UMLS CUI [1,1])
C0006935 (UMLS CUI [1,2])
Intelligence quotient Minimum Requirement
Item
a minimum iq of 80 will be required.
boolean
C0456149 (UMLS CUI [1,1])
C1524031 (UMLS CUI [1,2])
C1514873 (UMLS CUI [1,3])
Bipolar Disorder | Schizophrenia | Psychotic Disorders | Autistic Disorder | Pervasive Development Disorder | Gilles de la Tourette syndrome
Item
current or past dsm-iv-tr diagnoses of bipolar disorder, schizophrenia, psychosis, autism/pervasive developmental disorder (pdd), and tourette's disorder (td).
boolean
C0005586 (UMLS CUI [1])
C0036341 (UMLS CUI [2])
C0033975 (UMLS CUI [3])
C0004352 (UMLS CUI [4])
C0524528 (UMLS CUI [5])
C0040517 (UMLS CUI [6])
Eating Disorders | Panic Disorder | Obsessive-Compulsive Disorder | Post-Traumatic Stress Disorder | Conduct Disorder | Substance Use Disorders | Exception Nicotine abuse
Item
current diagnosis of eating disorder, panic disorder, obsessive-compulsive disorder (ocd), post traumatic stress disorder (ptsd), conduct disorder, and substance related disorders other than nicotine.
boolean
C0013473 (UMLS CUI [1])
C0030319 (UMLS CUI [2])
C0028768 (UMLS CUI [3])
C0038436 (UMLS CUI [4])
C0149654 (UMLS CUI [5])
C0038586 (UMLS CUI [6])
C1705847 (UMLS CUI [7,1])
C2363943 (UMLS CUI [7,2])
Feeling suicidal | Suicidal intent | Planning suicide | DANGER OF HARM TO SELF
Item
current suicidal ideation with intent or plan, or who may pose a danger to themselves.
boolean
C0424000 (UMLS CUI [1])
C0582496 (UMLS CUI [2])
C0424001 (UMLS CUI [3])
C0149660 (UMLS CUI [4])
Antidepressive Agents
Item
current antidepressant treatment will be excluded. past antidepressant treatment will not be exclusionary, so long as patients are off antidepressant medication for 60 days prior to study entry. no individual will be advised to terminate ongoing treatment.
boolean
C0003289 (UMLS CUI [1])
Pharmaceutical Preparations Half-Life Short | Vitamins Containing Ingredient Unidentified | Hypericum perforatum | S-Adenosylmethionine | Clonidine | Non-Prescription Drugs Some
Item
certain short half-life medications, such as vitamins that contain unidentified ingredients, st. johns wort, s-adenosyl methionine (sam), clonidine, and some over-the-counter medications.
boolean
C0013227 (UMLS CUI [1,1])
C0018517 (UMLS CUI [1,2])
C1806781 (UMLS CUI [1,3])
C0042890 (UMLS CUI [2,1])
C0332256 (UMLS CUI [2,2])
C1550600 (UMLS CUI [2,3])
C0205427 (UMLS CUI [2,4])
C0936242 (UMLS CUI [3])
C0036002 (UMLS CUI [4])
C0009014 (UMLS CUI [5])
C0013231 (UMLS CUI [6,1])
C0205392 (UMLS CUI [6,2])
Pharmaceutical Preparations Half-Life Long | Antipsychotic Agents | Stimulant ADHD Acceptable
Item
a minimum of 90 days off of treatment with long half life medications, such as neuroleptics, prior to study entry is required. stimulant medication treatment for adhd will not be exclusionary.
boolean
C0013227 (UMLS CUI [1,1])
C0018517 (UMLS CUI [1,2])
C0205166 (UMLS CUI [1,3])
C0040615 (UMLS CUI [2])
C0304402 (UMLS CUI [3,1])
C1263846 (UMLS CUI [3,2])
C1879533 (UMLS CUI [3,3])
Psychotherapy Started | Psychotherapy Previous Continue allowed
Item
if adolescents have been in psychotherapy prior to their entry in the study, they will be allowed to continue with the treatment. however, psychotherapy cannot be initiated at the time of study entry.
boolean
C0033968 (UMLS CUI [1,1])
C1272689 (UMLS CUI [1,2])
C0033968 (UMLS CUI [2,1])
C0205156 (UMLS CUI [2,2])
C0549178 (UMLS CUI [2,3])
C0683607 (UMLS CUI [2,4])