Gender
Item
1. male or female patients
boolean
C0079399 (UMLS CUI [1])
Age | Osteoarthritis of knee Kellgren-Lawrence score | Conventional Treatment Symptomatic Unsuccessful
Item
2. patients aged 45 years or more with grade iv [based on the international cartilage repair society(icrs) evaluation criteria from the mri scan results] degenerative arthritis of the knee, whose symptoms had not been relieved by the conventional symptomatic treatment
boolean
C0001779 (UMLS CUI [1])
C0409959 (UMLS CUI [2,1])
C3177117 (UMLS CUI [2,2])
C2945704 (UMLS CUI [3,1])
C0231220 (UMLS CUI [3,2])
C1272705 (UMLS CUI [3,3])
Healthy | Physical Examination Finding Major Absent | Hematology Finding Major Absent | Serum Chemistry Finding Major Absent | Urinalysis Finding Major Absent
Item
3. healthy, with no major physical examination, hematology, serum chemistry, and urine test findings and no significant medical history
boolean
C3898900 (UMLS CUI [1])
C0031809 (UMLS CUI [2,1])
C0243095 (UMLS CUI [2,2])
C0205164 (UMLS CUI [2,3])
C0332197 (UMLS CUI [2,4])
C0200627 (UMLS CUI [3,1])
C0243095 (UMLS CUI [3,2])
C0205164 (UMLS CUI [3,3])
C0332197 (UMLS CUI [3,4])
C1883010 (UMLS CUI [4,1])
C0243095 (UMLS CUI [4,2])
C0205164 (UMLS CUI [4,3])
C0332197 (UMLS CUI [4,4])
C0042014 (UMLS CUI [5,1])
C0243095 (UMLS CUI [5,2])
C0205164 (UMLS CUI [5,3])
C0332197 (UMLS CUI [5,4])
Cartilage damage Size
Item
4. patients with cartilage damage sized 2-6 cm2 (based on the icrs evaluation criteria from the mri scan results)
boolean
C0549421 (UMLS CUI [1,1])
C0456389 (UMLS CUI [1,2])
Informed Consent
Item
5. voluntarily agreed to participate in this study and signed the informed consent form
boolean
C0021430 (UMLS CUI [1])
Hematology Clinical Significance | Serum Chemistry Measurement Clinical Significance | Urine test results Clinical Significance
Item
1. showed clinically significant hematology, serum chemistry, or urine test results at the screening visit
boolean
C0200627 (UMLS CUI [1,1])
C2826293 (UMLS CUI [1,2])
C1883010 (UMLS CUI [2,1])
C2826293 (UMLS CUI [2,2])
C0851020 (UMLS CUI [3,1])
C2826293 (UMLS CUI [3,2])
Anti-Inflammatory Agents prescribed | Anti-Inflammatory Agents Non-Prescription Drugs | Other Coding
Item
2. took an anti-inflammatory medication (prescribed or over-the-counter), including natural medicine, within 14 days from the administration of the investigational product
boolean
C0003209 (UMLS CUI [1,1])
C0278329 (UMLS CUI [1,2])
C0003209 (UMLS CUI [2,1])
C0013231 (UMLS CUI [2,2])
C3846158 (UMLS CUI [3])
Drug abuse | Urine drug screening Positive | Blood alcohol test positive
Item
3. has a history of drug abuse within one year from the enrollment, or the urine test or blood alcohol test result was positive at the screening visit
boolean
C0013146 (UMLS CUI [1])
C0202274 (UMLS CUI [2,1])
C1514241 (UMLS CUI [2,2])
C0948726 (UMLS CUI [3])
Injection Target Knee
Item
4. received any injection in the target knee within two months before the initiation of the study
boolean
C1533685 (UMLS CUI [1,1])
C1521840 (UMLS CUI [1,2])
C0022742 (UMLS CUI [1,3])
Pregnancy | Breast Feeding
Item
5. pregnant or breastfeeding female
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Arthropathy | Exception Degenerative arthritis | Systemic disease Knee | Rheumatism knee | Inflammatory disorder Knee | Calcium pyrophosphate deposition disease | Hemochromatosis | Inflammatory Arthritis | Necrosis Trochanter | Osteitis Deformans Adjacent to Joint Femur | Osteitis Deformans Adjacent to Joint Tibia | Ochronosis | Hemophilic arthropathy | Arthritis, Infectious | Neurogenic arthropathy Knee joint | Villonodular synovitis | Synovial chondroma
Item
6. with another joint disease apart from degenerative arthritis (e.g., systemic rheumatic inflammatory disease associated with the knee or chondrocalcinosis, hemachromatosis, inflammatory arthritis, necrosis of the trochanter, paget's disease adjacent to a joint in the femur or the tibia, ochronosis, hemophilic arthropathy, infectious arthritis, charcot's disease in the knee joint, villonodular synovitis, and synovial chondromas)
boolean
C0022408 (UMLS CUI [1])
C1705847 (UMLS CUI [2,1])
C0029408 (UMLS CUI [2,2])
C0442893 (UMLS CUI [3,1])
C0022742 (UMLS CUI [3,2])
C0564818 (UMLS CUI [4])
C1290884 (UMLS CUI [5,1])
C0022742 (UMLS CUI [5,2])
C0553730 (UMLS CUI [6])
C0018995 (UMLS CUI [7])
C0003864 (UMLS CUI [8])
C0027540 (UMLS CUI [9,1])
C0162370 (UMLS CUI [9,2])
C0029401 (UMLS CUI [10,1])
C0205117 (UMLS CUI [10,2])
C0022417 (UMLS CUI [10,3])
C0015811 (UMLS CUI [10,4])
C0029401 (UMLS CUI [11,1])
C0205117 (UMLS CUI [11,2])
C0022417 (UMLS CUI [11,3])
C1279118 (UMLS CUI [11,4])
C0028817 (UMLS CUI [12])
C0263725 (UMLS CUI [13])
C0003869 (UMLS CUI [14])
C0003892 (UMLS CUI [15,1])
C0022745 (UMLS CUI [15,2])
C0158168 (UMLS CUI [16])
C0948674 (UMLS CUI [17])
Communicable Disease | HIV Infection | Hepatitis B | Hepatitis C
Item
7. with an infectious disease, including hiv or hepatitis (hbv/hcv)
boolean
C0009450 (UMLS CUI [1])
C0019693 (UMLS CUI [2])
C0019163 (UMLS CUI [3])
C0019196 (UMLS CUI [4])
Disease Clinical Significance
Item
8. with a history any of the following clinically significant diseases:
boolean
C0012634 (UMLS CUI [1,1])
C2826293 (UMLS CUI [1,2])
Heart Diseases | Myocardial Infarction | Cardiac Arrhythmia | Heart Diseases Serious | Coronary Artery Bypass Surgery
Item
heart disease [e.g., myocardial infarction, arrhythmia, other serious heart disease, coronary artery bypass graft (cabg)]
boolean
C0018799 (UMLS CUI [1])
C0027051 (UMLS CUI [2])
C0003811 (UMLS CUI [3])
C0018799 (UMLS CUI [4,1])
C0205404 (UMLS CUI [4,2])
C0010055 (UMLS CUI [5])
Kidney Diseases | Kidney Failure, Chronic | Glomerulonephritis
Item
kidney disease (e.g., chronic renal failure, glomerulonephritis)
boolean
C0022658 (UMLS CUI [1])
C0022661 (UMLS CUI [2])
C0017658 (UMLS CUI [3])
Liver diseases | Liver Cirrhosis | Fatty Liver | Chronic liver disease
Item
liver disease (e.g., liver cirrhosis, fatty liver, acute or chronic liver disease)
boolean
C0023895 (UMLS CUI [1])
C0023890 (UMLS CUI [2])
C0015695 (UMLS CUI [3])
C0341439 (UMLS CUI [4])
Endocrine System Diseases | Hyperthyroidism | Hypothyroidism | Thyroiditis | Diabetes Insipidus | Cushing's disease
Item
endocrine disease (e.g., hyperthyroidism, hypothyroidism, thyroiditis, diabetes insipidus, cushing's disease)
boolean
C0014130 (UMLS CUI [1])
C0020550 (UMLS CUI [2])
C0020676 (UMLS CUI [3])
C0040147 (UMLS CUI [4])
C0011848 (UMLS CUI [5])
C0221406 (UMLS CUI [6])
Diabetes Mellitus, Insulin-Dependent
Item
insulin-dependent diabetes mellitus
boolean
C0011854 (UMLS CUI [1])
Malignant Neoplasms | Other Coding
Item
medical history of or current malignant tumor in particular, the tumors that tissuegene-c may aggravate can be screened using the following tests
boolean
C0006826 (UMLS CUI [1])
C3846158 (UMLS CUI [2])
Leukemia | White Blood Cell Count procedure Hematology
Item
leukemia : white blood cell level in the hematology
boolean
C0023418 (UMLS CUI [1])
C0023508 (UMLS CUI [2,1])
C0200627 (UMLS CUI [2,2])
Cartilaginous exostosis | Chondroma | Chondroblastoma | Chondromyxoid fibroma | Chondrosarcoma | Alkaline phosphatase measurement Hematology
Item
osteochondroma, chondromas, chondroblastoma, chondromyxoid fibroma, chondrosarcoma : alkaline phosphatase level in the hematology
boolean
C0029423 (UMLS CUI [1])
C0936248 (UMLS CUI [2])
C0008441 (UMLS CUI [3])
C0221290 (UMLS CUI [4])
C0008479 (UMLS CUI [5])
C0201850 (UMLS CUI [6,1])
C0200627 (UMLS CUI [6,2])
Study Subject Participation Status | Investigational New Drugs | Investigational Medical Device
Item
9. participated in another clinical trial (using the investigational drug or a medical device) within 30 days before enrollment in this study
boolean
C2348568 (UMLS CUI [1])
C0013230 (UMLS CUI [2])
C2346570 (UMLS CUI [3])
Drug screen Positive
Item
10. showed positive drug test results at the screening visit
boolean
C0373483 (UMLS CUI [1,1])
C1514241 (UMLS CUI [1,2])
Contraceptive methods Unwilling
Item
11. did not agree to use a contraceptive method (male and female)
boolean
C0700589 (UMLS CUI [1,1])
C0558080 (UMLS CUI [1,2])