Healthy | Age | Serum LDL cholesterol measurement Circulating Fasting | Triglycerides measurement Circulating Fasting
Item
1. healthy males and females, aged 19-60 yr, will be screened for determination of fasting circulating ldl-cholesterol and tg levels.
boolean
C3898900 (UMLS CUI [1])
C0001779 (UMLS CUI [2])
C0428474 (UMLS CUI [3,1])
C0175630 (UMLS CUI [3,2])
C0015663 (UMLS CUI [3,3])
C0202236 (UMLS CUI [4,1])
C0175630 (UMLS CUI [4,2])
C0015663 (UMLS CUI [4,3])
Plasma LDL cholesterol measurement | Triglycerides measurement
Item
2. subjects accepted into the study will have plasma ldl-c 130-200 mg/dl, tg levels below 250 mg/dl.
boolean
C1278149 (UMLS CUI [1])
C0202236 (UMLS CUI [2])
Body mass index
Item
3. the inclusion for body mass index (bmi) range will be 22 to 32 kg/m2.
boolean
C1305855 (UMLS CUI [1])
Comprehension Diet therapy | Comprehension Exercise | Compliance behavior
Item
4. subjects must also demonstrate an ability to understand dietary procedures and exercise procedures and be judged as compliant and motivated by the investigators.
boolean
C0162340 (UMLS CUI [1,1])
C0012159 (UMLS CUI [1,2])
C0162340 (UMLS CUI [2,1])
C0015259 (UMLS CUI [2,2])
C1321605 (UMLS CUI [3])
Thyroid Hormone Preparations Dose Stable | Antihypertensive Agents Dose Stable
Item
5. subjects will be permitted to take stable doses of thyroid hormone and anti-hypertensive agents, as long as these are continued equivalently throughout the duration of study.
boolean
C0040135 (UMLS CUI [1,1])
C0013227 (UMLS CUI [1,2])
C0178602 (UMLS CUI [1,3])
C0205360 (UMLS CUI [1,4])
C0003364 (UMLS CUI [2,1])
C0178602 (UMLS CUI [2,2])
C0205360 (UMLS CUI [2,3])
Hypolipidemic Agents Oral | Hypolipidemic Agents Oral chronic | Fish Oils | Probucol
Item
1. history of recent (i.e. less than 3 months) or chronic use of oral hypolipidemic therapy, including fish oils, or probucol within the last 6 months.
boolean
C0086440 (UMLS CUI [1,1])
C1527415 (UMLS CUI [1,2])
C0086440 (UMLS CUI [2,1])
C1527415 (UMLS CUI [2,2])
C0205191 (UMLS CUI [2,3])
C0016157 (UMLS CUI [3])
C0033215 (UMLS CUI [4])
Alcohol consumption chronic Drinks per day | Antibodies Systemic | Adrenal Cortex Hormones | Androgens | Phenytoin
Item
2. history of chronic use of alcohol (> 2 drinks/day), systemic antibodies, corticosteroids, androgens, or phenytoin.
boolean
C0001948 (UMLS CUI [1,1])
C0205191 (UMLS CUI [1,2])
C0001967 (UMLS CUI [1,3])
C0439505 (UMLS CUI [1,4])
C3495458 (UMLS CUI [2,1])
C0205373 (UMLS CUI [2,2])
C0001617 (UMLS CUI [3])
C0002844 (UMLS CUI [4])
C0031507 (UMLS CUI [5])
Myocardial Infarction | Coronary Artery Bypass Surgery | Major surgery
Item
3. myocardial infarction, coronary artery bypass, or other major surgical procedures within the last six months.
boolean
C0027051 (UMLS CUI [1])
C0010055 (UMLS CUI [2])
C0679637 (UMLS CUI [3])
Angina Pectoris Onset | Congestive heart failure | Inflammatory Bowel Disease | Pancreatitis | Diabetes Mellitus | Gastrointestinal Disease | Kidney Disease | Lung disease | Liver disease | Gall Bladder Disease | Malignant Neoplasms | Lesion | Chemotherapy | Operative Surgical Procedures
Item
4. recent onset of angina, congestive heart failure, inflammatory bowel disease, pancreatitis, diabetes, or significant current (ie. onset within past three months) gastrointestinal, renal, pulmonary, hepatic or biliary disease, or cancer (evidence of active lesions, chemotherapy or surgery in the past year).
boolean
C0002962 (UMLS CUI [1,1])
C0332162 (UMLS CUI [1,2])
C0018802 (UMLS CUI [2])
C0021390 (UMLS CUI [3])
C0030305 (UMLS CUI [4])
C0011849 (UMLS CUI [5])
C0017178 (UMLS CUI [6])
C0022658 (UMLS CUI [7])
C0024115 (UMLS CUI [8])
C0023895 (UMLS CUI [9])
C0016977 (UMLS CUI [10])
C0006826 (UMLS CUI [11])
C0221198 (UMLS CUI [12])
C0392920 (UMLS CUI [13])
C0543467 (UMLS CUI [14])
Exercise Miles Weekly | Exercise kcal Weekly
Item
5. exercise greater than 15 miles/wk or 4,000 kcal/wk.
boolean
C0015259 (UMLS CUI [1,1])
C0331865 (UMLS CUI [1,2])
C0332174 (UMLS CUI [1,3])
C0015259 (UMLS CUI [2,1])
C0439259 (UMLS CUI [2,2])
C0332174 (UMLS CUI [2,3])