Coronary Artery Disease | Prior myocardial infarction
Item
1. evidence of coronary artery disease (cad) a or documented prior myocardial infarction.
boolean
C1956346 (UMLS CUI [1])
C0155668 (UMLS CUI [2])
Left ventricular ejection fraction Echocardiogram | Left ventricular ejection fraction Multiple gated acquisition scanning | Left ventricular ejection fraction Angiography | Heart failure New York Heart Association Classification | Ventricular Tachyarrhythmia Absent | Induced ventricular tachycardia Absent | Cardiac Electrophysiology
Item
2. lvef >35% by any current standard evaluation technique (e.g.,) echocardiogram, muga, angiography). 2.1. patients who have an lvef between 30-35% and nyha class i heart failure who do not have history of ventricular tachyarrhythmias,or inducible ventricular tachycardia during electrophysiological (ep) testing can be enrolled.
boolean
C0428772 (UMLS CUI [1,1])
C2243117 (UMLS CUI [1,2])
C0428772 (UMLS CUI [2,1])
C0521317 (UMLS CUI [2,2])
C0428772 (UMLS CUI [3,1])
C0002978 (UMLS CUI [3,2])
C0018801 (UMLS CUI [4,1])
C1275491 (UMLS CUI [4,2])
C0042514 (UMLS CUI [5,1])
C0332197 (UMLS CUI [5,2])
C0340486 (UMLS CUI [6,1])
C0332197 (UMLS CUI [6,2])
C0430467 (UMLS CUI [7])
Prior myocardial infarction Absent | Mild left ventricular systolic dysfunction | Moderate left ventricular systolic dysfunction | Cardiac ejection fraction Echocardiogram | Cardiac ejection fraction Multiple gated acquisition scanning | Cardiac ejection fraction Angiography
Item
3. if documented prior mi is not present, evidence of mild-moderate systolic left ventricular dysfunction with an ef >35- ≤50% as measured by any current standard screening technique (e.g.,echocardiogram, muga, angiography) must be present.
boolean
C0155668 (UMLS CUI [1,1])
C0332197 (UMLS CUI [1,2])
C3266750 (UMLS CUI [2])
C3266752 (UMLS CUI [3])
C0232174 (UMLS CUI [4,1])
C2243117 (UMLS CUI [4,2])
C0232174 (UMLS CUI [5,1])
C0521317 (UMLS CUI [5,2])
C0232174 (UMLS CUI [6,1])
C0002978 (UMLS CUI [6,2])
Age
Item
4. patients aged 18 years or above
boolean
C0001779 (UMLS CUI [1])
Coronary Artery Disease Criteria Quantity
Item
1. cad will be defined as evidence of one of the following two (2) criteria:
boolean
C1956346 (UMLS CUI [1,1])
C0243161 (UMLS CUI [1,2])
C1265611 (UMLS CUI [1,3])
Stenosis Percentage Coronary angiography | Vessel Epicardial Major Proximal | Vessel Epicardial Major Distal
Item
significant stenosis of a major epicardial vessel (>50% proximal or 70% distal) by coronary angiography
boolean
C1261287 (UMLS CUI [1,1])
C0439165 (UMLS CUI [1,2])
C0085532 (UMLS CUI [1,3])
C0005847 (UMLS CUI [2,1])
C0442016 (UMLS CUI [2,2])
C0205164 (UMLS CUI [2,3])
C0205107 (UMLS CUI [2,4])
C0005847 (UMLS CUI [3,1])
C0442016 (UMLS CUI [3,2])
C0205164 (UMLS CUI [3,3])
C0205108 (UMLS CUI [3,4])
Coronary revascularisation | Percutaneous Coronary Intervention | Coronary Artery Bypass Surgery
Item
prior revascularization (percutaneous coronary intervention or coronary artery bypass surgery)
boolean
C0877341 (UMLS CUI [1])
C1532338 (UMLS CUI [2])
C0010055 (UMLS CUI [3])
Myocardial Infarction criteria
Item
2. mi can be documented in the following ways:
boolean
C0027051 (UMLS CUI [1,1])
C0243161 (UMLS CUI [1,2])
Myocardial Infarction Hospitalization | Cardiac biomarkers Percentile | Elevated creatine kinase | Troponin increased | Myocardial Ischemia
Item
from the mi hospitalization: detection of a rise and fall of cardiac biomarkers > 99th percentile of lab (e.g., cpk elevation or troponin at least > two times the upper limit of normal) together with myocardial ischemia with at least one of the following:
boolean
C0027051 (UMLS CUI [1,1])
C0019993 (UMLS CUI [1,2])
C2735102 (UMLS CUI [2,1])
C1264641 (UMLS CUI [2,2])
C0151576 (UMLS CUI [3])
C1141948 (UMLS CUI [4])
C0151744 (UMLS CUI [5])
Symptoms Ischemia
Item
symptoms of ischemia
boolean
C1457887 (UMLS CUI [1,1])
C0022116 (UMLS CUI [1,2])
Electrocardiographic changes Indication of Ischemia New | ST-T change New | Left bundle branch block New
Item
ecg changes indicative of new ischemia (new st-t changes or new lbbb)
boolean
C0855329 (UMLS CUI [1,1])
C0392360 (UMLS CUI [1,2])
C0022116 (UMLS CUI [1,3])
C0205314 (UMLS CUI [1,4])
C0919620 (UMLS CUI [2,1])
C0205314 (UMLS CUI [2,2])
C0344420 (UMLS CUI [3,1])
C0205314 (UMLS CUI [3,2])
Q waves Pathological
Item
development of pathological q waves
boolean
C1305738 (UMLS CUI [1,1])
C1521733 (UMLS CUI [1,2])
New Loss of Viable Myocardium Imaging | Cardiac wall motion dysfunction regional new
Item
imaging evidence of new loss of viable myocardium or new regional wall motion abnormality
boolean
C3898142 (UMLS CUI [1])
C2024793 (UMLS CUI [2,1])
C0205147 (UMLS CUI [2,2])
C0205314 (UMLS CUI [2,3])
Prior myocardial infarction criteria
Item
if no report from the mi hospitalization is available, prior mi can be met by either of the following:
boolean
C0155668 (UMLS CUI [1,1])
C0243161 (UMLS CUI [1,2])
Q waves Pathological
Item
development of pathological q waves
boolean
C1305738 (UMLS CUI [1,1])
C1521733 (UMLS CUI [1,2])
Loss of Viable Myocardium Imaging regional
Item
imaging evidence of a region of loss of viable myocardium that is thinned and fails to contract, in the absence of a non-ischaemic cause
boolean
C3898142 (UMLS CUI [1,1])
C0205147 (UMLS CUI [1,2])
Cardiac Arrest | Spontaneous Sustained Ventricular Tachycardia | Sustained ventricular tachycardia Inducible
Item
1. history of cardiac arrest or spontaneous or inducible sustained vt (15 beats or more at a rate of 120 bpm or greater - the occurrence of cardiac arrest or spontaneous vt in the setting of an acute mi is not considered an exclusion).
boolean
C0018790 (UMLS CUI [1])
C3272259 (UMLS CUI [2])
C0750197 (UMLS CUI [3,1])
C0205263 (UMLS CUI [3,2])
Syncope Unknown
Item
2. unexplained syncope
boolean
C0039070 (UMLS CUI [1,1])
C0439673 (UMLS CUI [1,2])
Implantable defibrillator | Implantable defibrillator Planned
Item
3. current or planned implantable cardiac defibrillator (icd)
boolean
C0162589 (UMLS CUI [1])
C0162589 (UMLS CUI [2,1])
C1301732 (UMLS CUI [2,2])
Condition Life Expectancy Limited Serious | Exception Heart Disease
Item
4. any condition other than cardiac disease that, in the investigator's judgment, would seriously limit life expectancy (poor survival)
boolean
C0348080 (UMLS CUI [1,1])
C0023671 (UMLS CUI [1,2])
C0439801 (UMLS CUI [1,3])
C0205404 (UMLS CUI [1,4])
C1705847 (UMLS CUI [2,1])
C0018799 (UMLS CUI [2,2])
Neoplasm Metastasis
Item
5. metastatic cancer
boolean
C0027627 (UMLS CUI [1])
Heart valve disease Marked Requirement Operative Surgical Procedures
Item
6. marked valvular heart disease requiring surgical intervention
boolean
C0018824 (UMLS CUI [1,1])
C1706089 (UMLS CUI [1,2])
C1514873 (UMLS CUI [1,3])
C0543467 (UMLS CUI [1,4])
Heart Transplantation | Kidney Transplantation | Transplantation of liver | Heart Transplantation Planned | Kidney Transplantation Planned | Transplantation of liver Planned
Item
7. current or planned cardiac, renal or liver transplant
boolean
C0018823 (UMLS CUI [1])
C0022671 (UMLS CUI [2])
C0023911 (UMLS CUI [3])
C0018823 (UMLS CUI [4,1])
C1301732 (UMLS CUI [4,2])
C0022671 (UMLS CUI [5,1])
C1301732 (UMLS CUI [5,2])
C0023911 (UMLS CUI [6,1])
C1301732 (UMLS CUI [6,2])
Substance Use Disorders
Item
8. current alcohol or drug abuse
boolean
C0038586 (UMLS CUI [1])
Informed Consent Unwilling | Informed Consent Unable
Item
9. unwilling or unable to provide informed consent
boolean
C0021430 (UMLS CUI [1,1])
C0558080 (UMLS CUI [1,2])
C0021430 (UMLS CUI [2,1])
C1299582 (UMLS CUI [2,2])
Left ventricular ejection fraction | Congestive heart failure New York Heart Association Classification
Item
10. lvef <35% with class ii-iii chf or lvef <30%
boolean
C0428772 (UMLS CUI [1])
C0018802 (UMLS CUI [2,1])
C1275491 (UMLS CUI [2,2])
Study Subject Participation Status | Anti-Arrhythmia Agents | Intervention Against Cardiac Arrhythmia
Item
11. participation in a clinical trial where the active treatment arm is testing an agent and/or intervention with known antiarrhythmic properties
boolean
C2348568 (UMLS CUI [1])
C0003195 (UMLS CUI [2])
C0184661 (UMLS CUI [3,1])
C0521124 (UMLS CUI [3,2])
C0003811 (UMLS CUI [3,3])