Colorectal Carcinoma Advanced CEA Expression | Standard therapy Lacking
Item
patients with cea expressing advanced colorectal tumors for which no standard treatment is available
boolean
C0009402 (UMLS CUI [1,1])
C0205179 (UMLS CUI [1,2])
C0007082 (UMLS CUI [1,3])
C0017262 (UMLS CUI [1,4])
C2936643 (UMLS CUI [2,1])
C0332268 (UMLS CUI [2,2])
WHO performance status scale
Item
who performance status: 0 or 1
boolean
C1298650 (UMLS CUI [1])
Hematologic function | Neutrophil count | Platelet Count measurement | Transfusion Absent | Hemoglobin measurement
Item
having normal hematological function: neutrophils > 1.5 x 109/l; platelet count > 150 x 109/l, without transfusion during the previous month; hemoglobin > 5.6 mmol/l
boolean
C0221130 (UMLS CUI [1])
C0200633 (UMLS CUI [2])
C0032181 (UMLS CUI [3])
C1879316 (UMLS CUI [4,1])
C0332197 (UMLS CUI [4,2])
C0518015 (UMLS CUI [5])
Serum total bilirubin measurement
Item
total bilirubin < 2 x upper limit of normal (uln)
boolean
C1278039 (UMLS CUI [1])
Aspartate aminotransferase measurement | Alanine aminotransferase measurement
Item
asat, alat < 3 x uln
boolean
C0201899 (UMLS CUI [1])
C0201836 (UMLS CUI [2])
Creatinine measurement, serum
Item
serum creatinine < 2 x uln
boolean
C0201976 (UMLS CUI [1])
Estimation of creatinine clearance by Cockcroft-Gault formula
Item
cockcroft clearance > 50 ml/min
boolean
C2711451 (UMLS CUI [1])
Childbearing Potential Urine pregnancy test negative | Childbearing Potential Serum pregnancy test negative
Item
negative pregnancy test for women of child¬bearing potential (urine or serum)
boolean
C3831118 (UMLS CUI [1,1])
C0430057 (UMLS CUI [1,2])
C3831118 (UMLS CUI [2,1])
C0430061 (UMLS CUI [2,2])
Age
Item
age over 18 years
boolean
C0001779 (UMLS CUI [1])
Informed Consent
Item
ability to provide written informed consent
boolean
C0021430 (UMLS CUI [1])
brain metastases
Item
known metastases to the brain
boolean
C0220650 (UMLS CUI [1])
Chemotherapy | External Beam Radiation Therapy | Immunotherapy | Allowance External Beam Radiation Therapy Field Limited | Prevention Pathological fracture
Item
chemotherapy, external beam radiation or immunotherapy within 4 weeks prior to study. limited field external beam radiotherapy to prevent pathological fractures is allowed, when unirradiated, evaluable lesions elsewhere are present.
boolean
C0392920 (UMLS CUI [1])
C1517033 (UMLS CUI [2])
C0021083 (UMLS CUI [3])
C0556660 (UMLS CUI [4,1])
C1517033 (UMLS CUI [4,2])
C1882536 (UMLS CUI [4,3])
C0439801 (UMLS CUI [4,4])
C0199176 (UMLS CUI [5,1])
C0016663 (UMLS CUI [5,2])
Angiogenesis Inhibitors | bevacizumab
Item
prior angiogenesis inhibitors within 4 weeks; bevacizumab within 8 weeks
boolean
C0596087 (UMLS CUI [1])
C0796392 (UMLS CUI [2])
Heart Disease New York Heart Association Classification
Item
cardiac disease with new york heart association classification of iii or iv
boolean
C0018799 (UMLS CUI [1,1])
C1275491 (UMLS CUI [1,2])
Pregnancy | Breast Feeding | Childbearing Potential Contraceptive methods Lacking
Item
patients who are pregnant, nursing or of reproductive potential and are not practicing an effective method of contraception
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
C3831118 (UMLS CUI [3,1])
C0700589 (UMLS CUI [3,2])
C0332268 (UMLS CUI [3,3])
Illness Independent of Colorectal Carcinoma | Communicable Disease | Inflammation | Medical condition Affecting Patient Clinical status | Laboratory test result abnormal Affecting Patient Clinical status
Item
any unrelated illness, e.g. active infection, inflammation, medical condition or laboratory abnormalities, which in the judgement of the investigator will significantly affect patients' clinical status
boolean
C0221423 (UMLS CUI [1,1])
C0332291 (UMLS CUI [1,2])
C0009402 (UMLS CUI [1,3])
C0009450 (UMLS CUI [2])
C0021368 (UMLS CUI [3])
C3843040 (UMLS CUI [4,1])
C0392760 (UMLS CUI [4,2])
C0030705 (UMLS CUI [4,3])
C0449440 (UMLS CUI [4,4])
C0438215 (UMLS CUI [5,1])
C0392760 (UMLS CUI [5,2])
C0030705 (UMLS CUI [5,3])
C0449440 (UMLS CUI [5,4])
Life Expectancy
Item
life expectancy shorter than 6 months.
boolean
C0023671 (UMLS CUI [1])