Adult | Age
Item
adult patients >/=18 years of age
boolean
C0001675 (UMLS CUI [1])
C0001779 (UMLS CUI [2])
Colorectal cancer metastatic
Item
metastatic colorectal cancer
boolean
C0948380 (UMLS CUI [1])
Measurable lesion Quantity
Item
at least 1 measurable lesion according to recist v. 1.1
boolean
C1513041 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
Disease Progression | FOLFIRI Regimen | Avastin | Absence Schedule Metastasectomy Primary
Item
patients with disease progression with prior folfiri + avastin therapy who are not candidates for primary metastasectomy
boolean
C0242656 (UMLS CUI [1])
C1880658 (UMLS CUI [2])
C1135130 (UMLS CUI [3])
C0332197 (UMLS CUI [4,1])
C0030703 (UMLS CUI [4,2])
C2363923 (UMLS CUI [4,3])
C0205225 (UMLS CUI [4,4])
Disease Progression
Item
disease progression </= 8 weeks after last dose of avastin
boolean
C0242656 (UMLS CUI [1])
ECOG performance status
Item
ecog </=2
boolean
C1520224 (UMLS CUI [1])
First line treatment | FOLFIRI Regimen | Avastin | Second line treatment | XELOX | FOLFOX Regimen
Item
no more than 8 weeks between 1st-line treatment with folfiri + avastin and 2nd-line treatment with xelox or folfox + avastin
boolean
C1708063 (UMLS CUI [1])
C1880658 (UMLS CUI [2])
C1135130 (UMLS CUI [3])
C1710038 (UMLS CUI [4])
C1956962 (UMLS CUI [5])
C0392943 (UMLS CUI [6])
Disease Progression | Status post Avastin
Item
disease progression > 8 weeks after last avastin administration
boolean
C0242656 (UMLS CUI [1])
C0231290 (UMLS CUI [2,1])
C1135130 (UMLS CUI [2,2])
Cardiovascular Disease
Item
clinically significant cardiovascular disease
boolean
C0007222 (UMLS CUI [1])
CNS disorder | Exception Metastatic malignant neoplasm to brain Treated
Item
cns disease except for treated brain metastasis
boolean
C0007682 (UMLS CUI [1])
C1705847 (UMLS CUI [2,1])
C0220650 (UMLS CUI [2,2])
C1522326 (UMLS CUI [2,3])
Cancer Other | Exception Curative treatment Basal cell carcinoma | Exception Curative treatment Squamous cell carcinoma of skin | Exception Curative treatment Carcinoma in situ of uterine cervix
Item
history of other malignancies within 2 years prior to start of study treatment (with the exception of curatively treated basal and squamous cell carcinoma of the skin or in situ carcinoma of the cervix)
boolean
C1707251 (UMLS CUI [1])
C1705847 (UMLS CUI [2,1])
C1273390 (UMLS CUI [2,2])
C0007117 (UMLS CUI [2,3])
C1705847 (UMLS CUI [3,1])
C1273390 (UMLS CUI [3,2])
C0553723 (UMLS CUI [3,3])
C1705847 (UMLS CUI [4,1])
C1273390 (UMLS CUI [4,2])
C0851140 (UMLS CUI [4,3])
Major surgery | Incisional biopsy | Traumatic injury
Item
major surgery, open biopsy, or significant traumatic injury within 28 days prior to start of study treatment
boolean
C0679637 (UMLS CUI [1])
C0184922 (UMLS CUI [2])
C3263723 (UMLS CUI [3])