Colorectal Carcinoma | Neoplasm Metastasis
Item
1. patient with histologically confirmed colorectal cancer and/or clinical evidence of metastasis;
boolean
C0009402 (UMLS CUI [1])
C0027627 (UMLS CUI [2])
Measurable lesion Quantity CT scan | Measurable lesion Quantity MRI
Item
2. at least one measurable lesion either by computer tomography (ct) scan or magnetic resonance imaging (mri);
boolean
C1513041 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
C0040405 (UMLS CUI [1,3])
C1513041 (UMLS CUI [2,1])
C1265611 (UMLS CUI [2,2])
C0024485 (UMLS CUI [2,3])
Age
Item
3. aged 20 years old or above;
boolean
C0001779 (UMLS CUI [1])
ECOG performance status
Item
4. eastern cooperative oncology group (ecog) performance status < 2;
boolean
C1520224 (UMLS CUI [1])
Mature Neutrophils Present Bone Marrow | Hemoglobin measurement | Absolute neutrophil count | Platelet Count measurement
Item
5. adequate bone marrow reserve (hemoglobin > 9 g/dl, absolute neutrophil count > 1.5 x 109/l, platelets > 100 x 109/l);
boolean
C1708947 (UMLS CUI [1,1])
C0005953 (UMLS CUI [1,2])
C0518015 (UMLS CUI [2])
C0948762 (UMLS CUI [3])
C0032181 (UMLS CUI [4])
Renal function | Liver function | Serum total bilirubin measurement | Creatinine measurement, serum | Alanine aminotransferase measurement | Aspartate aminotransferase measurement
Item
6. adequate renal and hepatic functions: total bilirubin < 1.25 x upper normal limit, creatinine < 1.25 x upper normal limit, alanine aminotransferase (alt) or aspartate aminotransferase (ast) < 2.5 x upper normal limit;
boolean
C0232804 (UMLS CUI [1])
C0232741 (UMLS CUI [2])
C1278039 (UMLS CUI [3])
C0201976 (UMLS CUI [4])
C0201836 (UMLS CUI [5])
C0201899 (UMLS CUI [6])
Informed Consent
Item
7. patients willing to participate in the trial and giving written informed consent.
boolean
C0021430 (UMLS CUI [1])
Pregnancy | Breast Feeding
Item
1. pregnant or lactating patients;
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Fertility Contraceptive methods Lacking
Item
2. patients (male or female) with reproductive potential not using adequate contraceptive measures;
boolean
C0015895 (UMLS CUI [1,1])
C0700589 (UMLS CUI [1,2])
C0332268 (UMLS CUI [1,3])
CNS metastases
Item
3. patients with evidence of central nervous system metastasis;
boolean
C0686377 (UMLS CUI [1])
Communicable Disease Requirement Systemic therapy | Antibiotics | Antifungal Agents | Antiviral Agents
Item
4. subject with active infection which requires systemic treatment of antibiotic, antifungal, or antiviral agents
boolean
C0009450 (UMLS CUI [1,1])
C1514873 (UMLS CUI [1,2])
C1515119 (UMLS CUI [1,3])
C0003232 (UMLS CUI [2])
C0003308 (UMLS CUI [3])
C0003451 (UMLS CUI [4])
Chronic diarrhea
Item
5. current history of chronic diarrhea;
boolean
C0401151 (UMLS CUI [1])
Illness Serious | Medical condition Serious | Angina Pectoris | Myocardial Infarction
Item
6. other serious illness or medical conditions (e.g.: history of angina, myocardial infarction);
boolean
C0221423 (UMLS CUI [1,1])
C0205404 (UMLS CUI [1,2])
C3843040 (UMLS CUI [2,1])
C0205404 (UMLS CUI [2,2])
C0002962 (UMLS CUI [3])
C0027051 (UMLS CUI [4])
Second Primary Cancers | Exception Basal cell carcinoma Treated | Exception Carcinoma in situ of uterine cervix Treated
Item
7. history of second primary malignancies except for adequately treated basal cell carcinoma of the skin or carcinoma in situ of the cervix;
boolean
C0751623 (UMLS CUI [1])
C1705847 (UMLS CUI [2,1])
C0007117 (UMLS CUI [2,2])
C1522326 (UMLS CUI [2,3])
C1705847 (UMLS CUI [3,1])
C0851140 (UMLS CUI [3,2])
C1522326 (UMLS CUI [3,3])
Cancer treatment Other
Item
8. concurrent treatment with any other anticancer therapy;
boolean
C0920425 (UMLS CUI [1,1])
C0205394 (UMLS CUI [1,2])
Congestive heart failure New York Heart Association Classification | Epilepsy | Other medical condition Significant
Item
9. patients with congestive heart failure (new york heart association functional classification iii or iv), epilepsy, or other significant medical conditions as judged by the investigator;
boolean
C0018802 (UMLS CUI [1,1])
C1275491 (UMLS CUI [1,2])
C0014544 (UMLS CUI [2])
C3843040 (UMLS CUI [3,1])
C0750502 (UMLS CUI [3,2])
Investigational New Drugs
Item
10. patients treated with another investigational drug within 4 weeks of entry into this study.
boolean
C0013230 (UMLS CUI [1])