Adenocarcinoma of large intestine metastatic
Item
1. metastatic colorectal adenocarcinoma.
boolean
C1319315 (UMLS CUI [1,1])
C1522484 (UMLS CUI [1,2])
KRAS mutation Tumor
Item
2. confirmed k-ras mutant tumor
boolean
C2747837 (UMLS CUI [1,1])
C0027651 (UMLS CUI [1,2])
Disease Progression | oxaliplatin | irinotecan | bevacizumab
Item
3. disease progression on oxaliplatin- and irinotecan-containing regimens, with at least one of these regimens containing bevacizumab.
boolean
C0242656 (UMLS CUI [1])
C0069717 (UMLS CUI [2])
C0123931 (UMLS CUI [3])
C0796392 (UMLS CUI [4])
ECOG performance status
Item
4. eastern cooperative oncology group (ecog) performance status of ≤ 1.
boolean
C1520224 (UMLS CUI [1])
Chemotherapy | Hormone Therapy | Immunotherapy | Cancer treatment | Therapy, Investigational
Item
1. use of chemotherapy, hormonal therapy, immunotherapy or any other cancer or experimental treatment ≤ 28 days prior to the first day of the first cycle.
boolean
C0392920 (UMLS CUI [1])
C0279025 (UMLS CUI [2])
C0021083 (UMLS CUI [3])
C0920425 (UMLS CUI [4])
C0949266 (UMLS CUI [5])
Therapeutic radiology procedure Bone Marrow Percentage
Item
2. radiotherapy for up to ≥ 30% of the bone marrow.
boolean
C1522449 (UMLS CUI [1,1])
C0005953 (UMLS CUI [1,2])
C0439165 (UMLS CUI [1,3])
Operative Surgical Procedures | Permission Minimally Invasive Surgical Procedure Diagnostic procedure | Permission Minimally Invasive Surgical Procedures Staging of disease
Item
3. surgery ≤ 28 days before day 1 of the first cycle (minimally invasive interventions for diagnostic purposes or disease staging are permitted).
boolean
C0543467 (UMLS CUI [1])
C0521104 (UMLS CUI [2,1])
C0282624 (UMLS CUI [2,2])
C0430022 (UMLS CUI [2,3])
C0521104 (UMLS CUI [3,1])
C0282624 (UMLS CUI [3,2])
C0449385 (UMLS CUI [3,3])
cetuximab | panitumumab | pomalidomide | CC-4047 | lenalidomide | Thalidomide
Item
4. previous treatment with cetuximab, panitumumab, pomalidomide (cc-4047), lenalidomide or thalidomide.
boolean
C0995188 (UMLS CUI [1])
C0879427 (UMLS CUI [2])
C2347624 (UMLS CUI [3])
C1176324 (UMLS CUI [4])
C1144149 (UMLS CUI [5])
C0039736 (UMLS CUI [6])
Metastatic malignant neoplasm to brain Symptomatic Untreated | Imaging of brain Redundant
Item
5. untreated, symptomatic brain metastases (brain imaging not required).
boolean
C0220650 (UMLS CUI [1,1])
C0231220 (UMLS CUI [1,2])
C0332155 (UMLS CUI [1,3])
C0203860 (UMLS CUI [2,1])
C1313915 (UMLS CUI [2,2])
Venous Thromboembolism
Item
6. venous thromboembolism ≤ 6 months before day1 of the first cycle.
boolean
C1861172 (UMLS CUI [1])
Congestive heart failure New York Heart Association Classification
Item
7. current congestive heart failure (classes ii to iv of the new york heart association).
boolean
C0018802 (UMLS CUI [1,1])
C1275491 (UMLS CUI [1,2])
Myocardial Infarction
Item
8. myocardial infarction ≤ 12 months before day1 of the first cycle.
boolean
C0027051 (UMLS CUI [1])
Uncontrolled hypertension
Item
9. uncontrolled hypertension.
boolean
C1868885 (UMLS CUI [1])