Age | Informed Consent
Item
cases and controls will be males and females aged 35 or older, and will give an informed consent to participate in the study.
boolean
C0001779 (UMLS CUI [1])
C0021430 (UMLS CUI [2])
Liver carcinoma Case
Item
* hepatocellular carcinoma case:
boolean
C2239176 (UMLS CUI [1,1])
C1706256 (UMLS CUI [1,2])
Liver carcinoma Evolving Liver Cirrhosis
Item
all hepatocellular carcinoma cases evolving in cirrhotic liver, whatever the etiology of cirrhosis, will be included. criteria for the diagnosis of hepatocellular carcinoma will be those defined by the european association for study of the liver (easl) (bruix j, j hepatol 2001):
boolean
C2239176 (UMLS CUI [1,1])
C0332253 (UMLS CUI [1,2])
C0023890 (UMLS CUI [1,3])
Lesion of liver Focal Diameter
Item
focal hepatic lesions ≥ 2cm in diameter:
boolean
C0577053 (UMLS CUI [1,1])
C0205234 (UMLS CUI [1,2])
C1301886 (UMLS CUI [1,3])
Alpha-fetoprotein measurement | Nodule Identification | Examination morphological Quantity | Abdominal Ultrasound | Abdominal angiography | CT of abdomen | MRI of abdomen | Arterial Hypervascularization
Item
alpha-fetoprotein (afp) < 400 ng/ml: nodules have to be identified by at least two coincident morphologic examinations (abdominal us, angiography, ct or mri) with arterial hypervascularisation in at least one of the imaging modalities
boolean
C0201539 (UMLS CUI [1])
C0028259 (UMLS CUI [2,1])
C0205396 (UMLS CUI [2,2])
C0582103 (UMLS CUI [3,1])
C0543482 (UMLS CUI [3,2])
C1265611 (UMLS CUI [3,3])
C2348813 (UMLS CUI [4])
C0412251 (UMLS CUI [5])
C0412620 (UMLS CUI [6])
C0412693 (UMLS CUI [7])
C3831472 (UMLS CUI [8])
Alpha-fetoprotein measurement | Lesion seen Imaging
Item
afp > 400 ng/ml: lesion seen in a single imaging modality
boolean
C0201539 (UMLS CUI [1])
C0221198 (UMLS CUI [2,1])
C0205397 (UMLS CUI [2,2])
C0079595 (UMLS CUI [2,3])
Lesion of liver Focal Diameter
Item
focal hepatic lesions < 2 cm in diameter:
boolean
C0577053 (UMLS CUI [1,1])
C0205234 (UMLS CUI [1,2])
C1301886 (UMLS CUI [1,3])
Lesion Diameter Fine needle aspiration biopsy
Item
lesions 1 to 2 cm in diameter:use of fine-needle aspiration with biopsy
boolean
C0221198 (UMLS CUI [1,1])
C1301886 (UMLS CUI [1,2])
C1510483 (UMLS CUI [1,3])
Lesion Diameter Abdominal Ultrasound Series
Item
lesions < 1 cm: serial abdominal us every 3 months until the lesion exceeds 1 cm in size so that biopsy becomes possible. such cases will be included after diagnosis confirmation.
boolean
C0221198 (UMLS CUI [1,1])
C1301886 (UMLS CUI [1,2])
C2348813 (UMLS CUI [1,3])
C0205549 (UMLS CUI [1,4])
Lesion Focal Size | Liver Cirrhosis
Item
whatever the size of focal lesions, the diagnosis of cirrhosis will be made according to the same criteria as in the cirrhotic group control.
boolean
C0221198 (UMLS CUI [1,1])
C0205234 (UMLS CUI [1,2])
C0456389 (UMLS CUI [1,3])
C0023890 (UMLS CUI [2])
Patients Cirrhotic Control Group
Item
* cirrhotic control patients:
boolean
C0030705 (UMLS CUI [1,1])
C0439686 (UMLS CUI [1,2])
C0009932 (UMLS CUI [1,3])
Liver Cirrhosis
Item
all patients with cirrhosis, whatever its etiology, will be included. the diagnosis of cirrhosis will rely on:
boolean
C0023890 (UMLS CUI [1])
Biopsy of liver
Item
histological confirmation by liver biopsy or in the absence of biopsy:
boolean
C0193388 (UMLS CUI [1])
Portal vein thrombosis Free of Doppler Ultrasound Imaging | Portal Hypertension Biological measurement | Pancytopenia | Portal Hypertension Measurement morphological | Abdominal Ultrasound | CT of abdomen | MRI of abdomen | Portal Hypertension Hepatic venous pressure gradient | Endoscopy of stomach | Portal hypertensive gastropathy | Gastric Varices
Item
in patients free of portal thrombosis at doppler imaging, on the presence of portal hypertension ascertained by biological (tricytopenia), morphologic (abdominal us, ct or mri), hepatic venous pressure measurement or upper endoscopy (mosaic gastropathy, varices).
boolean
C0155773 (UMLS CUI [1,1])
C0332296 (UMLS CUI [1,2])
C2713308 (UMLS CUI [1,3])
C0020541 (UMLS CUI [2,1])
C0814047 (UMLS CUI [2,2])
C0030312 (UMLS CUI [3])
C0020541 (UMLS CUI [4,1])
C0242485 (UMLS CUI [4,2])
C0543482 (UMLS CUI [4,3])
C2348813 (UMLS CUI [5])
C0412620 (UMLS CUI [6])
C0412693 (UMLS CUI [7])
C0020541 (UMLS CUI [8,1])
C4049263 (UMLS CUI [8,2])
C0017195 (UMLS CUI [9])
C0580174 (UMLS CUI [10])
C0017145 (UMLS CUI [11])
Portal vein thrombosis | Portal Hypertension Associated with Sign or Symptom Liver Cirrhosis | Hepatomegaly Associated with Liver Failure | Spider nevus | Palmar erythema | Other Coding | Gynecomastia | Portal Hypertension Associated with Signs morphological Liver Cirrhosis | Hepatomegaly | Surface Nodular | Other Coding
Item
in patients with portal thrombosis, on the presence of portal hypertension associated with: clinical (hepatomegaly with clinical evidence of hepatocellular failure: spider naevi, palmar erythema, white mails, gynecomastia) or morphological signs of cirrhosis (enlarged liver, nodular surface, sharp lower edge).
boolean
C0155773 (UMLS CUI [1])
C0020541 (UMLS CUI [2,1])
C0332281 (UMLS CUI [2,2])
C3540840 (UMLS CUI [2,3])
C0023890 (UMLS CUI [2,4])
C0019209 (UMLS CUI [3,1])
C0332281 (UMLS CUI [3,2])
C0085605 (UMLS CUI [3,3])
C0085666 (UMLS CUI [4])
C0014745 (UMLS CUI [5])
C3846158 (UMLS CUI [6])
C0018418 (UMLS CUI [7])
C0020541 (UMLS CUI [8,1])
C0332281 (UMLS CUI [8,2])
C0220912 (UMLS CUI [8,3])
C0543482 (UMLS CUI [8,4])
C0023890 (UMLS CUI [8,5])
C0019209 (UMLS CUI [9])
C0205148 (UMLS CUI [10,1])
C0205297 (UMLS CUI [10,2])
C3846158 (UMLS CUI [11])
Signs biological Liver Failure | Total protein measurement | Blood albumin decreased | Sinusoid Obstruction | Hepatic venous pressure gradient | FibroTest Score Measurement | Other Coding
Item
and/or biological signs of hepatocellular failure (tp<70%, low albuminemia) and/or sinusoidal block assessed by liver venous gradient > 18mmhg in the present state of knowledge, a fibrotest value at 4 or a fibroscan value > 12.5 kilopascal.
boolean
C0220912 (UMLS CUI [1,1])
C0205460 (UMLS CUI [1,2])
C0085605 (UMLS CUI [1,3])
C0555903 (UMLS CUI [2])
C0853777 (UMLS CUI [3])
C0682624 (UMLS CUI [4,1])
C0028778 (UMLS CUI [4,2])
C4049263 (UMLS CUI [5])
C3642160 (UMLS CUI [6])
C3846158 (UMLS CUI [7])
Liver Cirrhosis | Hepatitis C, Chronic
Item
without any other clinical or biological signs will be considered as diagnosis criteria of cirrhosis only for chronic viral c hepatitis.
boolean
C0023890 (UMLS CUI [1])
C0524910 (UMLS CUI [2])
Patients Cirrhotic | Liver carcinoma Lacking | Imaging | Abdominal Ultrasound | CT of abdomen | MRI of abdomen | Alpha-fetoprotein measurement
Item
the lack of hepatocellular carcinoma in cirrhotic patients at inclusion will be assessed through good quality imaging examinations (abdominal us, ct scan or mri) and afp below 100 ng/ml.
boolean
C0030705 (UMLS CUI [1,1])
C0439686 (UMLS CUI [1,2])
C2239176 (UMLS CUI [2,1])
C0332268 (UMLS CUI [2,2])
C0079595 (UMLS CUI [3])
C2348813 (UMLS CUI [4])
C0412620 (UMLS CUI [5])
C0412693 (UMLS CUI [6])
C0201539 (UMLS CUI [7])
Age
Item
age under 35 of year
boolean
C0001779 (UMLS CUI [1])
Cancer Other Evolving
Item
other cancer in evolution
boolean
C1707251 (UMLS CUI [1,1])
C0332253 (UMLS CUI [1,2])
HIV Infection
Item
hiv infection
boolean
C0019693 (UMLS CUI [1])
Mental disorders Prevalence Somatic Major
Item
major somatic pr psychiatric illness not compatible with the inclusion in the study
boolean
C0004936 (UMLS CUI [1,1])
C0220900 (UMLS CUI [1,2])
C2986476 (UMLS CUI [1,3])
C0205164 (UMLS CUI [1,4])
Cancer Other | Exception Liver carcinoma
Item
no hepatocellular carcinoma primary liver cancer.
boolean
C1707251 (UMLS CUI [1])
C1705847 (UMLS CUI [2,1])
C2239176 (UMLS CUI [2,2])