Chronic Lymphocytic Leukemia | Small Lymphocytic Lymphoma
Item
a diagnosis of cll or sll based on iwcll diagnostic criteria.
boolean
C0023434 (UMLS CUI [1])
C0855095 (UMLS CUI [2])
Prior Therapy Quantity Chronic Lymphocytic Leukemia
Item
prior therapy for cll (no limit on number of prior regimens).
boolean
C1514463 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
C0023434 (UMLS CUI [1,3])
Patients Requirement Therapeutic procedure
Item
patients requiring therapy, based on at least one of the iwcll criteria.
boolean
C0030705 (UMLS CUI [1,1])
C1514873 (UMLS CUI [1,2])
C0087111 (UMLS CUI [1,3])
Age
Item
18 years of age or older.
boolean
C0001779 (UMLS CUI [1])
ECOG performance status
Item
performance status ecog 0, 1, or 2.
boolean
C1520224 (UMLS CUI [1])
Estimation of creatinine clearance by Cockcroft-Gault formula | Creatinine clearance measurement
Item
an estimated or measured creatinine clearance ≥30 ml/min at study enrollment.
boolean
C2711451 (UMLS CUI [1])
C0373595 (UMLS CUI [2])
Aspartate aminotransferase measurement | Alanine aminotransferase measurement | Serum total bilirubin measurement | Exception Result Due to CLL/SLL
Item
ast, alt, and total bilirubin ≤ 2.5 times the upper limit of normal, unless due to cll/sll.
boolean
C0201899 (UMLS CUI [1])
C0201836 (UMLS CUI [2])
C1278039 (UMLS CUI [3])
C1705847 (UMLS CUI [4,1])
C1274040 (UMLS CUI [4,2])
C0678226 (UMLS CUI [4,3])
C1302547 (UMLS CUI [4,4])
Postmenopausal state | Female Sterilization | Contraceptive methods Willing
Item
female subject who is either post-menopausal or surgically sterilized or male or female subject willing to use an acceptable method of birth control for the duration of the study therapy and for 2 weeks after study therapy completion.
boolean
C0232970 (UMLS CUI [1])
C0015787 (UMLS CUI [2])
C0700589 (UMLS CUI [3,1])
C0600109 (UMLS CUI [3,2])
Pregnancy | Breast Feeding
Item
female subject is pregnant or lactating.
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Investigational New Drugs
Item
patient has received other investigational drugs for this disease within 14 days of enrollment.
boolean
C0013230 (UMLS CUI [1])
HIV Infection
Item
patient with known hiv prior to enrollment.
boolean
C0019693 (UMLS CUI [1])
Disease Serious Interferes with Study Subject Participation Status | Mental disorder Serious Interferes with Study Subject Participation Status
Item
serious medical or psychiatric illness likely to interfere with participation in this clinical study.
boolean
C0012634 (UMLS CUI [1,1])
C0205404 (UMLS CUI [1,2])
C0521102 (UMLS CUI [1,3])
C2348568 (UMLS CUI [1,4])
C0004936 (UMLS CUI [2,1])
C0205404 (UMLS CUI [2,2])
C0521102 (UMLS CUI [2,3])
C2348568 (UMLS CUI [2,4])
Cancer Other | Remission Documented | Exception Basal cell carcinoma | Exception Squamous cell carcinoma of skin | Exception Carcinoma in situ of uterine cervix | Exception Prostate carcinoma Early stage | Systemic therapy Requirement Absent
Item
patients with another malignancy within the last three years (from documentation of remission) other than basal or squamous cell skin cancer or cis of the cervix or early stage prostate cancer not requiring systemic treatment.
boolean
C1707251 (UMLS CUI [1])
C0687702 (UMLS CUI [2,1])
C1301725 (UMLS CUI [2,2])
C1705847 (UMLS CUI [3,1])
C0007117 (UMLS CUI [3,2])
C1705847 (UMLS CUI [4,1])
C0553723 (UMLS CUI [4,2])
C1705847 (UMLS CUI [5,1])
C0851140 (UMLS CUI [5,2])
C1705847 (UMLS CUI [6,1])
C0600139 (UMLS CUI [6,2])
C2363430 (UMLS CUI [6,3])
C1515119 (UMLS CUI [7,1])
C1514873 (UMLS CUI [7,2])
C0332197 (UMLS CUI [7,3])
Allogeneic Stem Cell Transplantation | Engraftment Donor cells Percentage
Item
patients who underwent allogeneic stem cell transplant and have at least 2% donor cells engrafted will be excluded.
boolean
C2242529 (UMLS CUI [1])
C0301944 (UMLS CUI [2,1])
C2910947 (UMLS CUI [2,2])
C0439165 (UMLS CUI [2,3])
Cardiac event | Vascular Diseases | Myocardial Infarction | Angina, Unstable | Peripheral Vascular Disease Severe | Ischemic pain At rest Class | Non-healing ulcer of skin | Wound, non-healed | Congestive heart failure New York Heart Association Classification | Cardiac Arrhythmia Uncontrolled
Item
significant cardiac or vascular events within 6 months: acute mi, unstable angina, severe peripheral vascular disease (ischemic pain at rest class 3 or worse, non-healing ulcers/wounds, congestive heart failure (nhya class ≥ 2), uncontrolled cardiac arrhythmias.
boolean
C0741923 (UMLS CUI [1])
C0042373 (UMLS CUI [2])
C0027051 (UMLS CUI [3])
C0002965 (UMLS CUI [4])
C0085096 (UMLS CUI [5,1])
C0205082 (UMLS CUI [5,2])
C0745417 (UMLS CUI [6,1])
C0443144 (UMLS CUI [6,2])
C0456387 (UMLS CUI [6,3])
C0748826 (UMLS CUI [7])
C0750433 (UMLS CUI [8])
C0018802 (UMLS CUI [9,1])
C1275491 (UMLS CUI [9,2])
C0003811 (UMLS CUI [10,1])
C0205318 (UMLS CUI [10,2])
Severe allergy Perifosine | Severe allergy Perifosine Component
Item
known severe hypersensitivity to perifosine or any component of the formulation.
boolean
C2945656 (UMLS CUI [1,1])
C0754570 (UMLS CUI [1,2])
C2945656 (UMLS CUI [2,1])
C0754570 (UMLS CUI [2,2])
C1705248 (UMLS CUI [2,3])
Life Expectancy Due to Comorbidity
Item
life expectancy less than six months due to co-morbid illness
boolean
C0023671 (UMLS CUI [1,1])
C0678226 (UMLS CUI [1,2])
C0009488 (UMLS CUI [1,3])
Autoimmune hemolytic anemia Requirement Steroid therapy | Autoimmune thrombocytopenia Requirement Steroid therapy
Item
active autoimmune hemolytic anemia or immune thrombocytopenia, requiring current steroid therapy.
boolean
C0002880 (UMLS CUI [1,1])
C1514873 (UMLS CUI [1,2])
C0149783 (UMLS CUI [1,3])
C0242584 (UMLS CUI [2,1])
C1514873 (UMLS CUI [2,2])
C0149783 (UMLS CUI [2,3])
Prolymphocytic Leukemia de novo | Prolymphocytic Leukemia Due to CLL | Prolymphocytes Percentage
Item
de novo prolymphocytic leukemia (pll) or pll arising from cll (≥ 55% prolymphocytes).
boolean
C0023486 (UMLS CUI [1,1])
C1515568 (UMLS CUI [1,2])
C0023486 (UMLS CUI [2,1])
C0678226 (UMLS CUI [2,2])
C0023434 (UMLS CUI [2,3])
C0229614 (UMLS CUI [3,1])
C0439165 (UMLS CUI [3,2])
Richter's syndrome
Item
richter's transformation
boolean
C0349631 (UMLS CUI [1])