Age
Item
≥ 18 years of age,
boolean
C0001779 (UMLS CUI [1])
Maintenance hemodialysis Stable Frequency
Item
receiving stable maintenance hemodialysis 3 times a week
boolean
C4040576 (UMLS CUI [1,1])
C0205360 (UMLS CUI [1,2])
C0439603 (UMLS CUI [1,3])
Low phosphate diet
Item
on restricted phosphate diet at screening and throughout study
boolean
C0452351 (UMLS CUI [1])
Phosphate Binder Dose Stable
Item
receiving stable dose of phosphate binder for at least 1 month
boolean
C2267031 (UMLS CUI [1,1])
C0178602 (UMLS CUI [1,2])
C0205360 (UMLS CUI [1,3])
Serum Phosphate Measurement
Item
serum phosphate levels >1.78 mmol/l
boolean
C1883013 (UMLS CUI [1])
Exclusion Criteria Main
Item
main exclusion criteria:
boolean
C0680251 (UMLS CUI [1,1])
C1542147 (UMLS CUI [1,2])
Hyperphosphatemia Uncontrolled
Item
uncontrolled hyperphosphatemia
boolean
C0085681 (UMLS CUI [1,1])
C0205318 (UMLS CUI [1,2])
Hypercalcemia
Item
hypercalcemia at screening or during washout
boolean
C0020437 (UMLS CUI [1])
Serum calcium measurement
Item
serum calcium < 1.9 mmol/l (<7.6 mg/dl)
boolean
C0728876 (UMLS CUI [1])
Hyperparathyroidism Severe | Intact Parathyroid Hormone Measurement
Item
severe hyperparathyroidism (ipth levels >600 ng/l)
boolean
C0020502 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
C2697755 (UMLS CUI [2])
Pregnancy | Breast Feeding
Item
pregnancy or lactation
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Iron deficiency anemia
Item
iron deficiency anemia
boolean
C0162316 (UMLS CUI [1])
Hemochromatosis | Ferritin measurement
Item
history of hemochromatosis or ferritin >800 mg/l,
boolean
C0018995 (UMLS CUI [1])
C0373607 (UMLS CUI [2])
Hepatitis B | Hepatitis C | Liver diseases
Item
hepatitis b, hepatitis c or other significant concurrent liver disorders
boolean
C0019163 (UMLS CUI [1])
C0019196 (UMLS CUI [2])
C0023895 (UMLS CUI [3])
HIV Seropositivity
Item
known positivity to hiv
boolean
C0019699 (UMLS CUI [1])
Oral iron agent
Item
use of oral iron preparations 1 month before screening,
boolean
C1298638 (UMLS CUI [1])
Medical condition Serious | Systemic disease Uncontrolled
Item
serious medical condition or uncontrolled systemic disease
boolean
C3843040 (UMLS CUI [1,1])
C0205404 (UMLS CUI [1,2])
C0442893 (UMLS CUI [2,1])
C0205318 (UMLS CUI [2,2])