Age
Item
>18 years of age and <80 years of age
boolean
C0001779 (UMLS CUI [1])
Chronic heart failure | Condition Clinical Stable
Item
chronic heart failure subjects with stable clinical condition
boolean
C0264716 (UMLS CUI [1])
C0348080 (UMLS CUI [2,1])
C0205210 (UMLS CUI [2,2])
C0205360 (UMLS CUI [2,3])
New York Heart Association Classification
Item
new york heart association (nyha) functional classification ii-iii
boolean
C1275491 (UMLS CUI [1])
Left ventricular ejection fraction
Item
left ventricular ejection fraction (lvef) ≤45%
boolean
C0428772 (UMLS CUI [1])
New York Heart Association Classification
Item
nyha functional classification iv
boolean
C1275491 (UMLS CUI [1])
Myocardial Infarction | Angina, Unstable | Coronary Artery Bypass Surgery | Percutaneous Coronary Intervention | Operation on heart valve
Item
acute myocardial infarction, unstable angina pectoris, coronary artery bypass graft, percutaneous coronary intervention (pci), valve surgery in the preceding 3 months
boolean
C0027051 (UMLS CUI [1])
C0002965 (UMLS CUI [2])
C0010055 (UMLS CUI [3])
C1532338 (UMLS CUI [4])
C0190065 (UMLS CUI [5])
Bisoprolol allergy | Hypersensitivity Concor Excipient
Item
hypersensitivity to bisoprolol or any of the concor excipients
boolean
C0570886 (UMLS CUI [1])
C0020517 (UMLS CUI [2,1])
C0110591 (UMLS CUI [2,2])
C0015237 (UMLS CUI [2,3])
Valvular Stenosis Moderate | Valvular Stenosis Severe | Lung insufficiency Severe Grade
Item
subjects with over mild valvular stenosis and severe(grade iii/iv) pulmonary insufficiency
boolean
C1883524 (UMLS CUI [1,1])
C0205081 (UMLS CUI [1,2])
C1883524 (UMLS CUI [2,1])
C0205082 (UMLS CUI [2,2])
C1401064 (UMLS CUI [3,1])
C0205082 (UMLS CUI [3,2])
C0441800 (UMLS CUI [3,3])
Systolic Pressure
Item
systolic blood pressure <90 millimeters of mercury (mmhg) at screening
boolean
C0871470 (UMLS CUI [1])
Resting heart rate Electrocardiography
Item
resting heart rate <55 beats per minute (bpm) confirmed by electrocardiogram (ecg) at screening
boolean
C1821417 (UMLS CUI [1,1])
C1623258 (UMLS CUI [1,2])
Pharmaceutical Preparations At risk Drug Interaction Bisoprolol
Item
subjects who are taking concomitant drug which can have drug-drug interaction (ddi) with bisoprolol
boolean
C0013227 (UMLS CUI [1,1])
C1444641 (UMLS CUI [1,2])
C0687133 (UMLS CUI [1,3])
C0053799 (UMLS CUI [1,4])
Childbearing Potential Contraceptive methods Lacking | Pregnancy | Breast Feeding
Item
woman of childbearing age without effective contraception measures, or who are pregnant or lactating
boolean
C3831118 (UMLS CUI [1,1])
C0700589 (UMLS CUI [1,2])
C0332268 (UMLS CUI [1,3])
C0032961 (UMLS CUI [2])
C0006147 (UMLS CUI [3])