Primary central nervous system lymphoma untreated
Item
pathologically verified primary central nervous system lymphoma no prior pcnsl treatment.
boolean
C0280803 (UMLS CUI [1,1])
C0332155 (UMLS CUI [1,2])
Steroid therapy alone
Item
patients treated with steroids alone are eligible
boolean
C0149783 (UMLS CUI [1,1])
C0205171 (UMLS CUI [1,2])
Absence Lymphoma Except for Central Nervous System
Item
no signs of lymphoma outside the cns
boolean
C0332197 (UMLS CUI [1,1])
C0024299 (UMLS CUI [1,2])
C0332300 (UMLS CUI [1,3])
C3714787 (UMLS CUI [1,4])
ECOG performance status
Item
ecog performance status 0-4
boolean
C1520224 (UMLS CUI [1])
Age
Item
age > 17 and < 76 years
boolean
C0001779 (UMLS CUI [1])
Informed Consent | Informed Consent Guardian
Item
written informed consent from the patient or guardian
boolean
C0021430 (UMLS CUI [1])
C0021430 (UMLS CUI [2,1])
C1274041 (UMLS CUI [2,2])
Heart failure New York Heart Association Classification
Item
cardiac failure > 3
boolean
C0018801 (UMLS CUI [1,1])
C1275491 (UMLS CUI [1,2])
Pregnancy | Breast Feeding | Childbearing Potential Contraceptive methods
Item
pregnancy or lactation. women of childbearing potential are requested to use an effective method of contraception to avoid pregnancy for a period from entry to the study and at least 3 months after the last study medication
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
C3831118 (UMLS CUI [3,1])
C0700589 (UMLS CUI [3,2])
Cancer Other | Exception Disease Free of
Item
previous malignancy unless disease free for at least five years
boolean
C1707251 (UMLS CUI [1])
C1705847 (UMLS CUI [2,1])
C0012634 (UMLS CUI [2,2])
C0332296 (UMLS CUI [2,3])
Communicable Disease
Item
active infection.
boolean
C0009450 (UMLS CUI [1])
Patients At risk Tuberculosis | Test Latent Tuberculosis
Item
regarding tuberculosis, patients at risk should be tested for latent tb according local practice at each treating centre.
boolean
C0030705 (UMLS CUI [1,1])
C1444641 (UMLS CUI [1,2])
C0041296 (UMLS CUI [1,3])
C0039593 (UMLS CUI [2,1])
C1609538 (UMLS CUI [2,2])
HIV Seropositivity
Item
positive hiv status
boolean
C0019699 (UMLS CUI [1])
Organ Transplantation
Item
organ transplantation
boolean
C0029216 (UMLS CUI [1])
Serious mental illness
Item
serious psychiatric illness
boolean
C3841614 (UMLS CUI [1])
Radiotherapy to brain
Item
prior radiotherapy to the brain
boolean
C0948319 (UMLS CUI [1])
Anti-Inflammatory Agents Discontinuation Unsuccessful
Item
concomitant anti-inflammatory medication that cannot be discontinued
boolean
C0003209 (UMLS CUI [1,1])
C1444662 (UMLS CUI [1,2])
C1272705 (UMLS CUI [1,3])
Estimation of creatinine clearance by Cockcroft-Gault formula
Item
creatinine clearance < 60 ml/minute calculated by cockcroft and gault formula
boolean
C2711451 (UMLS CUI [1])
Peripheral blood Granulocyte count | Peripheral blood Platelet Count measurement
Item
peripheral blood count with granulocytes <1.5 x 109l or platelets < 100 x 109l
boolean
C0229664 (UMLS CUI [1,1])
C0857490 (UMLS CUI [1,2])
C0229664 (UMLS CUI [2,1])
C0032181 (UMLS CUI [2,2])
Elevated total bilirubin | Aspartate aminotransferase increased | Alkaline phosphatase raised
Item
serum bilirubin >1.5 times or asat and alkaline phosphatase >2 times upper limits of normal.
boolean
C0741494 (UMLS CUI [1])
C0151904 (UMLS CUI [2])
C0151849 (UMLS CUI [3])
Anaphylaxis murine protein | Immediate hypersensitivity murine protein | Anaphylaxis rituximab Component | Immediate hypersensitivity rituximab Component | rituximab
Item
known anaphylaxis or ige-mediated hypersensitivity to murine protein or any component of rituximab excludes patients from rituximab treatment, but not from the remaining part of the study
boolean
C0002792 (UMLS CUI [1,1])
C1699668 (UMLS CUI [1,2])
C0020523 (UMLS CUI [2,1])
C1699668 (UMLS CUI [2,2])
C0002792 (UMLS CUI [3,1])
C0393022 (UMLS CUI [3,2])
C1705248 (UMLS CUI [3,3])
C0020523 (UMLS CUI [4,1])
C0393022 (UMLS CUI [4,2])
C1705248 (UMLS CUI [4,3])
C0393022 (UMLS CUI [5])