Non-Small Cell Lung Carcinoma TNM clinical staging | Neoadjuvant Therapy Recommended
Item
histological diagnosis of non-small cell lung cancer that is stage iii (t1-3, pn2, m0) nsclc in whom neoadjuvant therapy is recommended.
boolean
C0007131 (UMLS CUI [1,1])
C3258246 (UMLS CUI [1,2])
C0600558 (UMLS CUI [2,1])
C0034866 (UMLS CUI [2,2])
Mediastinoscopy | Determination Lymph nodal status | Determination Status Resectable
Item
must have had a mediastinoscopy to determine nodal status and potential resectability
boolean
C0025065 (UMLS CUI [1])
C1148554 (UMLS CUI [2,1])
C0449927 (UMLS CUI [2,2])
C1148554 (UMLS CUI [3,1])
C0449438 (UMLS CUI [3,2])
C1514888 (UMLS CUI [3,3])
Biopsy Tissue specimen | Tissue Markers Determination
Item
must have enough tissue from the biopsy for tissue marker determination for correlative studies
boolean
C0005558 (UMLS CUI [1,1])
C1292533 (UMLS CUI [1,2])
C0183956 (UMLS CUI [2,1])
C1148554 (UMLS CUI [2,2])
Work up metastatic negative | Fluorodeoxyglucose F18 PET/CT | CT brain | MRI brain
Item
negative metastatic work up (fdg pet/ct, brain ct or mri)
boolean
C0750430 (UMLS CUI [1,1])
C1522484 (UMLS CUI [1,2])
C1513916 (UMLS CUI [1,3])
C0046056 (UMLS CUI [2,1])
C1699633 (UMLS CUI [2,2])
C0412585 (UMLS CUI [3])
C0412675 (UMLS CUI [4])
Radiotherapy to thorax Excluded
Item
no prior thoracic radiotherapy will be permitted
boolean
C4038705 (UMLS CUI [1,1])
C2828389 (UMLS CUI [1,2])
Age
Item
age 18 years or greater
boolean
C0001779 (UMLS CUI [1])
ECOG performance status | Karnofsky Performance Status
Item
ecog performance status 0-1 (karnofsky at least 70%)
boolean
C1520224 (UMLS CUI [1])
C0206065 (UMLS CUI [2])
Organ function | Bone Marrow function
Item
normal organ and marrow function
boolean
C0678852 (UMLS CUI [1])
C0005953 (UMLS CUI [2,1])
C0031843 (UMLS CUI [2,2])
HIV Infection Absent
Item
no known hiv infection
boolean
C0019693 (UMLS CUI [1,1])
C0332197 (UMLS CUI [1,2])
Pregnancy Absent
Item
not pregnant
boolean
C0032961 (UMLS CUI [1,1])
C0332197 (UMLS CUI [1,2])
Informed Consent
Item
ability to understand and the willingness to sign an informed consent document
boolean
C0021430 (UMLS CUI [1])
Pneumonectomy Patient need for
Item
patients requiring a pneumonectomy
boolean
C0032284 (UMLS CUI [1,1])
C0686904 (UMLS CUI [1,2])
Chemotherapy | Therapeutic radiology procedure | Adverse event Due to Pharmaceutical Preparations Previous | Recovery Lacking
Item
patients who have had chemotherapy or radiation therapy within 4 weeks prior to entering the study, or who have not recovered from adverse events due to agents administered earlier.
boolean
C0392920 (UMLS CUI [1])
C1522449 (UMLS CUI [2])
C0877248 (UMLS CUI [3,1])
C0678226 (UMLS CUI [3,2])
C0013227 (UMLS CUI [3,3])
C0205156 (UMLS CUI [3,4])
C2004454 (UMLS CUI [4,1])
C0332268 (UMLS CUI [4,2])
Radiotherapy to thorax
Item
prior thoracic radiation
boolean
C4038705 (UMLS CUI [1])
Investigational New Drugs
Item
treatment with any other investigational agents.
boolean
C0013230 (UMLS CUI [1])
Neoplasm Metastasis
Item
known metastases
boolean
C0027627 (UMLS CUI [1])
Allergic Reaction Compound Nelfinavir Similar
Item
history of allergic reactions attributed to compounds of similar chemical or biologic composition to nfv
boolean
C1527304 (UMLS CUI [1,1])
C1706082 (UMLS CUI [1,2])
C0525005 (UMLS CUI [1,3])
C2348205 (UMLS CUI [1,4])
Pharmaceutical Preparations Contraindicated Nelfinavir
Item
patients receiving drugs contraindicated with nfv will be excluded.
boolean
C0013227 (UMLS CUI [1,1])
C1444657 (UMLS CUI [1,2])
C0525005 (UMLS CUI [1,3])
Comorbidity Uncontrolled | Communicable Disease | Symptomatic congestive heart failure | Angina, Unstable | Cardiac Arrhythmia | Mental disorder Protocol Compliance Limited | Social situation Protocol Compliance Limited
Item
uncontrolled, intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study compliance.
boolean
C0009488 (UMLS CUI [1,1])
C0205318 (UMLS CUI [1,2])
C0009450 (UMLS CUI [2])
C0742758 (UMLS CUI [3])
C0002965 (UMLS CUI [4])
C0003811 (UMLS CUI [5])
C0004936 (UMLS CUI [6,1])
C0525058 (UMLS CUI [6,2])
C0439801 (UMLS CUI [6,3])
C0748872 (UMLS CUI [7,1])
C0525058 (UMLS CUI [7,2])
C0439801 (UMLS CUI [7,3])
Pregnancy | Breast Feeding
Item
pregnant or lactating women
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
HIV Seropositivity | Anti-Retroviral Agents Combined Modality Therapy
Item
hiv-positive patients on combination antiretroviral therapy
boolean
C0019699 (UMLS CUI [1])
C0599685 (UMLS CUI [2,1])
C0009429 (UMLS CUI [2,2])