Gender | Age
Item
1. female, age 18 years or older.
boolean
C0079399 (UMLS CUI [1])
C0001779 (UMLS CUI [2])
Breast Carcinoma untreated
Item
2. histologically proven breast cancer who have not received any prior therapy.
boolean
C0678222 (UMLS CUI [1,1])
C0332155 (UMLS CUI [1,2])
Locally advanced breast cancer TNM Breast tumor staging | Distant metastasis Absent | Exception Secondary malignant neoplasm of lymph node
Item
3. locally advanced disease stage iiia with no evidence of distant metastatic disease other than anatomical site lymph nodes.
boolean
C3495949 (UMLS CUI [1,1])
C0474926 (UMLS CUI [1,2])
C1269798 (UMLS CUI [2,1])
C0332197 (UMLS CUI [2,2])
C1705847 (UMLS CUI [3,1])
C0686619 (UMLS CUI [3,2])
HER2/Neu Positive
Item
4. her2-positive.
boolean
C2348909 (UMLS CUI [1])
Absolute neutrophil count
Item
1. absolute neutrophil count (anc) less than 1500/mm3.
boolean
C0948762 (UMLS CUI [1])
Platelet Count measurement
Item
2. platelet count less than 100 000/ mm3.
boolean
C0032181 (UMLS CUI [1])
Hemoglobin measurement
Item
3. hemoglobin level less than 9.0 g/dl.
boolean
C0518015 (UMLS CUI [1])
Serum total bilirubin measurement
Item
4. bilirubin greater than 1.5 mg/di.
boolean
C1278039 (UMLS CUI [1])
Aspartate aminotransferase increased | Alanine aminotransferase increased
Item
5. aspartate amino transferase (ast) or alanine amino transferase (alt) greater than twice the upper limit of normal.
boolean
C0151904 (UMLS CUI [1])
C0151905 (UMLS CUI [2])
Serum creatinine raised
Item
6. serum creatinine greater than 1.5 times of the upper normal limit.
boolean
C0700225 (UMLS CUI [1])
Gastrointestinal Diseases | Diarrhea
Item
7. significant or recent acute gastrointestinal disorders with diarrhea
boolean
C0017178 (UMLS CUI [1])
C0011991 (UMLS CUI [2])
Pregnancy | Breast Feeding
Item
8. pregnancy or breast-feeding.
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Organ system Dysfunction | Cardiac dysfunction | Left ventricular ejection fraction
Item
9. organ system dysfunction including cardiac (lvef < 50%).
boolean
C0460002 (UMLS CUI [1,1])
C3887504 (UMLS CUI [1,2])
C3277906 (UMLS CUI [2])
C0428772 (UMLS CUI [3])
Prior Chemotherapy | Prior radiation therapy | Prior Hormone Therapy | Trastuzumab | EGFR | EGFR inhibitor | HER2 inhibitors
Item
10. prior chemotherapy, radiotherapy or hormone therapy. previous treatment with trastuzumab, egfr, or egfr/her2-inhibitors.
boolean
C1514457 (UMLS CUI [1])
C0279134 (UMLS CUI [2])
C1514460 (UMLS CUI [3])
C0728747 (UMLS CUI [4])
C0034802 (UMLS CUI [5])
C1443775 (UMLS CUI [6])
C2916795 (UMLS CUI [7])
Cancer Other
Item
11. other malignancies diagnosed within the past five years.
boolean
C1707251 (UMLS CUI [1])
Communicable Disease Serious | HIV Infection | Hepatitis B | Hepatitis C
Item
12. serious active infection. hiv, active hepatitis b or c.
boolean
C0009450 (UMLS CUI [1,1])
C0205404 (UMLS CUI [1,2])
C0019693 (UMLS CUI [2])
C0019163 (UMLS CUI [3])
C0019196 (UMLS CUI [4])