Secondary malignant neoplasm of female breast Estrogen receptor positive Progressive | Secondary malignant neoplasm of female breast Progesterone receptor positive Progressive | Locally advanced breast cancer Estrogen receptor positive Progressive | Locally advanced breast cancer Progesterone receptor positive Progressive | Hormone Therapy First line
Item
patients with histological proven metastatic or locally advanced er+/pgr+ breast cancer in progression after receiving 1. line endocrine therapy.
boolean
C0346993 (UMLS CUI [1,1])
C0279754 (UMLS CUI [1,2])
C0205329 (UMLS CUI [1,3])
C0346993 (UMLS CUI [2,1])
C0279759 (UMLS CUI [2,2])
C0205329 (UMLS CUI [2,3])
C3495949 (UMLS CUI [3,1])
C0279754 (UMLS CUI [3,2])
C0205329 (UMLS CUI [3,3])
C3495949 (UMLS CUI [4,1])
C0279759 (UMLS CUI [4,2])
C0205329 (UMLS CUI [4,3])
C0279025 (UMLS CUI [5,1])
C1708063 (UMLS CUI [5,2])
Neoplasm Protein p53 Positive | performance status | Postmenopausal state | Age | Full blood count normal | Blood chemistry normal
Item
further inclusion criteria: p53+ tumour, ps≤1, postmenopausal. age >18, ps ≤ 1 and acceptable cbc and blood chemistry results
boolean
C0027651 (UMLS CUI [1,1])
C0080055 (UMLS CUI [1,2])
C1514241 (UMLS CUI [1,3])
C1518965 (UMLS CUI [2])
C0232970 (UMLS CUI [3])
C0001779 (UMLS CUI [4])
C0427692 (UMLS CUI [5])
C0438257 (UMLS CUI [6])
Neoplastic disease | Exception Carcinoma in situ of uterine cervix Treated | Exception Basal cell carcinoma Treated | Exception Squamous cell carcinoma of skin Treated
Item
patients with a history of any other neoplastic disease less than 5 years ago (excepting treated carcinoma in situ of the cervix and basal/squamous carcinoma of the skin)
boolean
C1882062 (UMLS CUI [1])
C1705847 (UMLS CUI [2,1])
C0851140 (UMLS CUI [2,2])
C1522326 (UMLS CUI [2,3])
C1705847 (UMLS CUI [3,1])
C0007117 (UMLS CUI [3,2])
C1522326 (UMLS CUI [3,3])
C1705847 (UMLS CUI [4,1])
C0553723 (UMLS CUI [4,2])
C1522326 (UMLS CUI [4,3])
CNS metastases
Item
patients with metastatic disease in the central nervous system
boolean
C0686377 (UMLS CUI [1])
Illness | Severe allergy | Asthma | Diabetes Mellitus | Angina Pectoris | Congestive heart failure
Item
patients with other significant illness including severe allergy, asthma, dm, angina pectoris or congestive heart failure
boolean
C0221423 (UMLS CUI [1])
C2945656 (UMLS CUI [2])
C0004096 (UMLS CUI [3])
C0011849 (UMLS CUI [4])
C0002962 (UMLS CUI [5])
C0018802 (UMLS CUI [6])
Communicable Disease | Chronic infectious disease | HIV Infection | Hepatitis | Tuberculosis
Item
patients with acute or chronic infection including hiv, hepatitis og tb
boolean
C0009450 (UMLS CUI [1])
C0151317 (UMLS CUI [2])
C0019693 (UMLS CUI [3])
C0019158 (UMLS CUI [4])
C0041296 (UMLS CUI [5])
Antineoplastic Drug/Agent Therapy | Chemotherapy | Therapeutic radiology procedure | Immunotherapy | Pharmaceutical Preparations
Item
patients who received antineoplastic therapy including chemotherapy, radiation, immunotherapy or other agents, less than 4 weeks before the beginning of the trial
boolean
C2346834 (UMLS CUI [1])
C0392920 (UMLS CUI [2])
C1522449 (UMLS CUI [3])
C0021083 (UMLS CUI [4])
C0013227 (UMLS CUI [5])
Adrenal Cortex Hormones | Immunosuppressive Agents
Item
patients who received corticosteroids or other immunosuppressive agents
boolean
C0001617 (UMLS CUI [1])
C0021081 (UMLS CUI [2])
Autoimmune Diseases | Lupus Erythematosus | Rheumatoid Arthritis | Thyroiditis
Item
patients with active autoimmune diseases such as lupus erythematosus, rheumatoid arthritis or thyroiditis
boolean
C0004364 (UMLS CUI [1])
C0409974 (UMLS CUI [2])
C0003873 (UMLS CUI [3])
C0040147 (UMLS CUI [4])
Hypercalcemia Severe
Item
severe hypercalcemia
boolean
C0020437 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])