Gender | Age
Item
women 18 years of age or older
boolean
C0079399 (UMLS CUI [1])
C0001779 (UMLS CUI [2])
Invasive carcinoma of breast Estrogen receptor positive | Invasive carcinoma of breast Progesterone receptor positive | Tamoxifen
Item
history of invasive er+ or pr+ breast cancer treated with at least 4.5 years of tamoxifen
boolean
C0853879 (UMLS CUI [1,1])
C0279754 (UMLS CUI [1,2])
C0853879 (UMLS CUI [2,1])
C0279759 (UMLS CUI [2,2])
C0039286 (UMLS CUI [3])
Recurrent disease Invasive Absent | Neoplasm Metastasis Absent | Bilateral breast cancer
Item
no current evidence of recurrent invasive disease or metastatic disease. patients may have a history of bilateral breast cancer
boolean
C0277556 (UMLS CUI [1,1])
C0205281 (UMLS CUI [1,2])
C0332197 (UMLS CUI [1,3])
C0027627 (UMLS CUI [2,1])
C0332197 (UMLS CUI [2,2])
C0281267 (UMLS CUI [3])
Premenopausal state | Estradiol measurement Premenopausal state
Item
premenopausal (estradiol level in premenopausal range, >20pg/ml, within the prior 28 days)
boolean
C0232969 (UMLS CUI [1])
C0337434 (UMLS CUI [2,1])
C0232969 (UMLS CUI [2,2])
Liver Function Tests | Creatinine measurement, serum
Item
liver function tests and creatinine <2.5 times the upper limit of normal within the 28 days prior to enrollment
boolean
C0023901 (UMLS CUI [1])
C0201976 (UMLS CUI [2])
ECOG performance status
Item
ecog performance status 0-1
boolean
C1520224 (UMLS CUI [1])
Contraceptive methods | Exception Hormonal contraception | Female Condoms | Vaginal contraceptive diaphragm | Intrauterine Devices | Female Sterilization | Sexual Abstinence | Hormone Therapy Absent | Letrozole Discontinued
Item
must agree to use non-hormonal contraception (condoms, diaphragm, iud, sterilization, abstinence, etc) and no other hormonal therapy during trial and until 3 months after letrozole is stopped
boolean
C0700589 (UMLS CUI [1])
C1705847 (UMLS CUI [2,1])
C2985296 (UMLS CUI [2,2])
C0221829 (UMLS CUI [3])
C0042241 (UMLS CUI [4])
C0021900 (UMLS CUI [5])
C0015787 (UMLS CUI [6])
C0036899 (UMLS CUI [7])
C0279025 (UMLS CUI [8,1])
C0332197 (UMLS CUI [8,2])
C0246421 (UMLS CUI [9,1])
C1444662 (UMLS CUI [9,2])
Pregnancy test negative
Item
negative pregnancy test within 14 days prior to enrollment
boolean
C0427780 (UMLS CUI [1])
Able to speak English Language | Able to read English Language | Able to write English Language
Item
patient must be able to speak, read and write in english
boolean
C0564215 (UMLS CUI [1,1])
C0376245 (UMLS CUI [1,2])
C0586740 (UMLS CUI [2,1])
C0376245 (UMLS CUI [2,2])
C0584993 (UMLS CUI [3,1])
C0376245 (UMLS CUI [3,2])
Diphosphonates Oral | Diphosphonates Intravenous
Item
previous treatment with an oral or iv bisphosphonate in the prior two years
boolean
C0012544 (UMLS CUI [1,1])
C1527415 (UMLS CUI [1,2])
C0012544 (UMLS CUI [2,1])
C1522726 (UMLS CUI [2,2])
Cancer Other | Exception Basal cell carcinoma | Exception Squamous cell carcinoma of skin | Exception Carcinoma in situ of uterine cervix
Item
history of cancer other than breast cancer within 5 years excluding basal/squamous cell skin carcinoma in situ of the cervix
boolean
C1707251 (UMLS CUI [1])
C1705847 (UMLS CUI [2,1])
C0007117 (UMLS CUI [2,2])
C1705847 (UMLS CUI [3,1])
C0553723 (UMLS CUI [3,2])
C1705847 (UMLS CUI [4,1])
C0851140 (UMLS CUI [4,2])
Breast cancer recurrent Local | Secondary malignant neoplasm of female breast
Item
women with evidence of current local recurrence or metastatic breast cancer
boolean
C0278493 (UMLS CUI [1,1])
C0205276 (UMLS CUI [1,2])
C0346993 (UMLS CUI [2])
Pregnancy
Item
pregnant women
boolean
C0032961 (UMLS CUI [1])
Breast Feeding
Item
nursing women
boolean
C0006147 (UMLS CUI [1])
Tamoxifen | Tamoxifen Discontinue Unwilling
Item
women who are currently taking tamoxifen and are unwilling to stop this medication
boolean
C0039286 (UMLS CUI [1])
C0039286 (UMLS CUI [2,1])
C1444662 (UMLS CUI [2,2])
C0558080 (UMLS CUI [2,3])
Gender | BRCA1 gene Deleterious Mutation | BRCA2 gene Deleterious Mutation
Item
women with a known deleterious brca 1 or brca 2 mutation
boolean
C0079399 (UMLS CUI [1])
C0376571 (UMLS CUI [2,1])
C2985436 (UMLS CUI [2,2])
C0598034 (UMLS CUI [3,1])
C2985436 (UMLS CUI [3,2])