Karnofsky Performance Status
Item
kps performance status of >= 80% ("normal activity with effort")
boolean
C0206065 (UMLS CUI [1])
Secondary malignant neoplasm of female breast | HER2 gene amplification FISH | HER2 Overexpression Immunohistochemistry
Item
metastatic breast cancer with her2 amplification by fish or 3+ her2 overexpression by immunohistochemistry ("ihc")
boolean
C0346993 (UMLS CUI [1])
C1512127 (UMLS CUI [2,1])
C0162789 (UMLS CUI [2,2])
C0069515 (UMLS CUI [3,1])
C1514559 (UMLS CUI [3,2])
C0021044 (UMLS CUI [3,3])
Cytotoxic Chemotherapy Quantity Neoplasm Metastasis
Item
must have received no more than one prior cytotoxic chemotherapy regimen in the metastatic setting
boolean
C0677881 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
C0027627 (UMLS CUI [1,3])
Measurable Disease
Item
measurable disease by recist criteria
boolean
C1513041 (UMLS CUI [1])
Lapatinib | erbB-2 inhibitors investigational | EGFR tyrosine kinase inhibitor Investigational
Item
received prior lapatinib, an investigational erbb-2 and/or an investigational egfr dual tyrosine kinase inhibitors
boolean
C1506770 (UMLS CUI [1])
C0069515 (UMLS CUI [2,1])
C0243077 (UMLS CUI [2,2])
C1517586 (UMLS CUI [2,3])
C1443775 (UMLS CUI [3,1])
C1517586 (UMLS CUI [3,2])
Chemotherapy | Biological treatment | Immunotherapy | Investigational New Drugs
Item
administration of any other chemotherapy, biological, immunotherapy or investigational agent within 14 days prior to receipt of study medication
boolean
C0392920 (UMLS CUI [1])
C1531518 (UMLS CUI [2])
C0021083 (UMLS CUI [3])
C0013230 (UMLS CUI [4])
Pregnancy | Breast Feeding | CNS metastases | Exception CNS metastases Treated | Exception Neurologic Deficits Absent
Item
pregnant or breast-feeding women. known cns metastases, unless treated and without clinically significant neurological deficits
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
C0686377 (UMLS CUI [3])
C1705847 (UMLS CUI [4,1])
C0686377 (UMLS CUI [4,2])
C1522326 (UMLS CUI [4,3])
C1705847 (UMLS CUI [5,1])
C0521654 (UMLS CUI [5,2])
C0332197 (UMLS CUI [5,3])
Dryness of eye Severe Moderately
Item
moderately severe dry eye
boolean
C0314719 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
C0205081 (UMLS CUI [1,3])
Congestive heart failure | Left ventricular ejection fraction
Item
congestive heart failure, or a left ventricular ejection fraction
boolean
C0018802 (UMLS CUI [1])
C0428772 (UMLS CUI [2])
Myocardial Infarction | Myocardial Ischemia
Item
myocardial infarction or active ischemic heart disease within 12 months prior to study drug administration
boolean
C0027051 (UMLS CUI [1])
C0151744 (UMLS CUI [2])
Malignant Neoplasms | Exception Recurrent disease Free of
Item
previous malignancies unless free of recurrence for at least 5 years
boolean
C0006826 (UMLS CUI [1])
C1705847 (UMLS CUI [2,1])
C0277556 (UMLS CUI [2,2])
C0332296 (UMLS CUI [2,3])