Postmenopausal state | Locally advanced breast cancer | Secondary malignant neoplasm of female breast
Item
post menopausal women with locally advanced or metastatic breast cancer
boolean
C0232970 (UMLS CUI [1])
C3495949 (UMLS CUI [2])
C0346993 (UMLS CUI [3])
Measurable Disease | Non-Measurable Lesion
Item
patients may have either measurable or non-measurable disease, as defined by recist criteria
boolean
C1513041 (UMLS CUI [1])
C1334988 (UMLS CUI [2])
Hormone Therapy Quantity Advanced disease | Chemotherapy Quantity Advanced disease | Stable Disease Post Chemotherapy
Item
one previous hormone therapy or one previous chemotherapy for advanced disease are allowed (patients who have stable but evident disease after chemotherapy are eligible)
boolean
C0279025 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
C0679246 (UMLS CUI [1,3])
C0392920 (UMLS CUI [2,1])
C1265611 (UMLS CUI [2,2])
C0679246 (UMLS CUI [2,3])
C0677946 (UMLS CUI [3,1])
C0687676 (UMLS CUI [3,2])
C0392920 (UMLS CUI [3,3])
Primary tumor Estrogen receptor positive | Primary tumor Progesterone receptor positive | Secondary Neoplasm Estrogen receptor positive | Secondary Neoplasm Progesterone receptor positive
Item
estrogen receptor positive er+ and/or progesterone receptor positive pr+ on primary or secondary tumour
boolean
C0677930 (UMLS CUI [1,1])
C0279754 (UMLS CUI [1,2])
C0677930 (UMLS CUI [2,1])
C0279759 (UMLS CUI [2,2])
C2939419 (UMLS CUI [3,1])
C0279754 (UMLS CUI [3,2])
C2939419 (UMLS CUI [4,1])
C0279759 (UMLS CUI [4,2])
Hormone receptor negative tumor | Estrogen receptor negative neoplasm | Progesterone receptor negative neoplasm
Item
hormone receptor negative tumours (er and pr negative)
boolean
C4272834 (UMLS CUI [1])
C2584629 (UMLS CUI [2])
C2584628 (UMLS CUI [3])
Neoplasm Metastasis Visceral Life Threatening
Item
presence of life-threatening metastatic visceral disease
boolean
C0027627 (UMLS CUI [1,1])
C0442045 (UMLS CUI [1,2])
C2826244 (UMLS CUI [1,3])
Cardiovascular event | Myocardial Infarction | Superior Vena Cava Syndrome | Heart Disease New York Heart Association Classification | Heart Diseases
Item
significant cardiovascular event (e.g. myocardial infarction, superior vena cava [svc] syndrome, new york heart association [nyha] classification of heart disease ³2) within 3 months before entry, or presence of cardiac disease that in the opinion of
boolean
C1320716 (UMLS CUI [1])
C0027051 (UMLS CUI [2])
C0038833 (UMLS CUI [3])
C0018799 (UMLS CUI [4,1])
C1275491 (UMLS CUI [4,2])
C0018799 (UMLS CUI [5])
Cardiac Arrhythmia | QTc interval Bazett formula Non-Measurable | QTc interval Bazett formula Electrocardiography
Item
history of arrhythmia or qtc with bazett's correction unmeasurable or ≥ 480 msec on screening ecg
boolean
C0003811 (UMLS CUI [1])
C4036473 (UMLS CUI [2,1])
C1518373 (UMLS CUI [2,2])
C4036473 (UMLS CUI [3,1])
C1623258 (UMLS CUI [3,2])